1921
Volume 76, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The mechanism by which the salivary gland lysate (SGL) of enables infection remains under investigation. One possibility is that saliva promotes cellular recruitment leading to development of skin lesions. In this study, we investigated leukocyte recruitment induced by SGL, or SGL alone into the peritoneal cavity of BALB/c mice. The administration of with or without SGL induced neutrophil migration six hours after infection. Interestingly, after seven days, the BALB/c mice still had eosinophils and mononuclear cells in their peritoneal cavities. Flow cytometric analysis showed an increase in the CD4+ CD45RB T cell subset (effector or memory cells) compared with the CD4+ CD45RB subset (naive cells). Moreover, the co-injection of with SGL enhanced production of interleukin-10. These results suggest that SGL can facilitate infection by modulating leukocyte recruitment and Th2 cytokine production at the inflammatory focus.

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2007-01-01
2017-11-17
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  • Received : 15 Mar 2006
  • Accepted : 13 Sep 2006

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