1921
Volume 76, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Chloroquine is the most commonly used antimalarial in Guinea-Bissau and high doses are routinely prescribed. Blood from 497 patients treated with different doses of chloroquine or amodiaquine were genotyped. and polymorphisms were identified. analysis identified recrudescent infections. The 72–76 haplotypes were CVIET and CVMNK. The 76T prevalence was 23% at day 0 and 96%, 83% and 100% at recrudescence following treatment with 25mg/kg and 50mg/kg of chloroquine and 15mg/kg of amodiaquine respectively. When treating 76T carrying the efficacy of 50 mg/kg and 25mg/kg of chloroquine was 78% and 34% respectively ( = 0.007). The genetic basis of chloroquine resistance is probably the same in Guinea-Bissau as in the rest of Africa. The low 76T prevalence suggests that resistance to normal dose chloroquine does not confer a major advantage to in Bissau and could be a result of treatment with high-dose chloroquine.

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2007-05-01
2017-09-26
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  • Received : 25 Aug 2006
  • Accepted : 13 Feb 2007

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