1921
Volume 76, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

West Nile virus (WNV) transmission generally involves a mosquito vector and an avian reservoir host, with mammals as incidental hosts. Although most mammalian WNV infections cause low or no morbidity or mortality, tree squirrels are susceptible to WNV-associated neurologic disease with infection prevalence comparable to that in dead birds. Positive species included fox squirrel (), western gray squirrel (), and eastern gray squirrel (). Kidney tissue (dissected and swabbed), and oropharyngeal (oral) swab samples from tree squirrels submitted by California vector control and rehabilitation agencies were tested by reverse transcription–polymerase chain reaction; cycle threshold values were similar for all three samples, ranging from 21.9 to 26.5. Kidney tissue was more sensitive than oral swabs for detecting WNV in squirrels. Three of 36 live neurologic tree squirrels had viremia approximately 5 log plaque-forming units/mL or greater, similar to WNV-infected birds. Tree squirrels are useful in WNV surveillance and provide localized evidence of WNV transmission to mammals.

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2007-05-01
2017-11-19
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References

  1. Anderson JF, Vossbrinck CR, Andreadis TG, Iton A, Beckwith WH, Mayo DR, 2001. Characterization of West Nile virus from five species of mosquitoes, nine species of birds, and one mammal. Ann N Y Acad Sci 951 : 328–331.
  2. Marfin AA, Petersen LR, Eidson M, Miller J, Hadler J, Farello C, Werner B, Campbell GL, Layton M, Smith P, Bresnitz E, Cartter M, Scaletta J, Obiri G, Bunning M, Craven RC, Roehrig JT, Julian KG, Hinten SR, Gubler DJ, the ArboNET Cooperative Surveillance Group 2001. Widespread West Nile virus activity, eastern United States, 2000. Emerg Infect Dis 7 : 730–735.
  3. Komar N, 2003. West Nile virus: epidemiology and ecology in North America. Adv Virus Res 61 : 185–234.
  4. Root JJ, Hall JS, Mclean RG, Marlenee NL, Beaty BJ, Gansowski J, Clark L, 2005. Serologic evidence of exposure of wild mammals to flavivirus in the central and eastern United States. Am J Trop Med Hyg 72 : 622–630.
  5. Root JJ, Oesterle PT, Nemeth NM, Klenk K, Gould DH, McLean RG, Clark L, Hall JS, 2006. Experimental infection of fox squirrels (Sciurus niger) with West Nile virus. Am J Trop Med Hyg 75 : 697–701.
  6. Kiupel M, Simmons HA, Fitzgerald SD, Wise A, Sikarskie JG, Cooley TM, Hollamby SR, Maes R, 2003. West Nile virus infection in eastern fox squirrels (Sciurus niger). Vet Pathol 40 : 703–707.
  7. MMWR Morb Mortal Wkly Rep, 2004. West Nile virus activity—United States, November 3–8, 2004. Available from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5344a7.htm
  8. MMWR Morb Mortal Wkly Rep, 2005. West Nile virus activity—2005. Available from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5441a7.htm
  9. MMWR Morb Mortal Wkly Rep, 2006. West Nile virus activity—United States January 1–August 15, 2006. Avilable from http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5532a3.htm
  10. Heinz-Taheny KM, Andrews JJ, Kinsel MJ, Pessier AP, Pinkerton ME, Lemberger KY, Novak RJ, Dizikes GJ, Edwards E, Komar N, 2004. West Nile virus infection in free-ranging squirrels in Illinois. J Vet Diagn Invest 16 : 186–190.
  11. Dietrich G, Montenieri JA, Panella NA, Langevin S, Lasater SE, Klenk K, Kile JC, Komar N, 2005. Serologic evidence of West Nile virus infection in free-ranging mammals, Slidell, Louisiana, 2002. Vector-Borne Zoon Dis 5 : 288–292.
  12. Milby MM, Reeves WC, 1990. Natural infection in vertebrate hosts other than man, Reeves WC, ed. Epidemiology and Control of Mosquito-Borne Arboviruses in California, 1943–1987. Sacramento CA: California Mosquito and Vector Control Association, 26–65.
  13. Day JF, Stark LM, Zhang J, Ramsey AM, Scott TW, 1996. Antibodies to arthropod-borne encephalitis viruses in small mammals form southern Florida. J Wild Dis 32 : 431–436.
  14. Timoney P, 1971. Powassan virus infection in the grey squirrel. Acta Virol 15 : 429.
  15. Ksiazek TG, Yuill TM, 1977. Viremia and antibody response to LaCrosse virus in sentinel gray squirrels (Sciuris carolinensis) and chipmunks (Tamias striatus). Am J Trop Med Hyg 26 : 815–821.
  16. Lennette EH, Ota MI, Dobbs ME, Browne AS, 1956. Isolation of western equine encephalomyelitis from naturally-infected squirrels in California. Am J Hyg 64 : 276–280.
  17. Xiao S, Guzman H, Zhang H, Travassos da Rosa APA, Tesh RB, 2001. West Nile virus infection in the golden hamster (Mesocricetus auratus): a model for West Nile encephalitis. Emerg Infect Dis 7 : 714–721.
  18. Kramer LD, Bernard KA, 2001. West Nile virus infection in birds and mammals. Ann N Y Acad Sci 951 : 84–93.
  19. McCaughey K, Miles S, Woods L, Chiles R, Hom A, Kramer V, Jay-Russell M, Sun B, Reisen W, Scott T, Hui L, Steinlein D, Castro M, Houchin A, Husted S, 2003. The California West Nile virus dead bird surveillance program. Presented at the Seventy-First Annual Conference of the Mosquito and Vector Control Association of California. Palm Springs, CA.
  20. Padgett KA, Cahoon-Young B, Carney R, Woods L, Read D, Husted S, Kramer V, 2006. Field and laboratory evaluation of diagnostic assays for detecting West Nile virus in oropharyngeal swabs from California wild birds. Vector Borne Zoonotic Dis 6 : 183–191.
  21. Campbell GL, Eldridge BF, Hardy JL, Reeves WC, Jessup DA, Presser SB, 1989. Prevalence of neutralizing antibodies against California and Bunyamwera serogroup viruses in deer from mountainous areas of California. Am J Trop Med Hyg 40 : 428–437.
  22. Reisen WK, Fang Y, Martinez VM, 2005. Avian host and mosquito (Diptera: Culicidae) vector competence determine the efficiency of West Nile and St. Louis encephalitis virus transmission. J Med Entomol 42 : 367–375.
  23. Komar N, Langevin S, Hinten S, Nemeth N, Edwards E, Hettler D, Davis B, Bowen R, Bunning M, 2003. Experimental infection of North American birds with the New York 1999 strain of West Nile virus. Emerg Infect Dis 9 : 311–322.
  24. Tiawsirisup S, Platt KB, Tucker BJ, Rowley WA, 2005. Eastern cottontail rabbits (Sylvilagus floridanus) develop West Nile virus sufficient to infect select mosquito species. Vector Borne Zoonotic Dis 5 : 342–350.
  25. Hardy JL, 1987. The ecology of western equine encephalomyelitis virus in the central valley of California, 1945–1985. Am J Trop Med Hyg 37 : 18s–32s.
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  • Received : 28 Sep 2006
  • Accepted : 19 Jan 2007

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