Volume 76, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue hemorrhagic fever (DHF). An immune mechanism of thrombocytopenia due to increased platelet destruction appears to be operative in patients with DHF (see Saito et al., 2004, 138: 299–303; Mitrakul, 1979, 26: 975–984; and Boonpucknavig, 1979, 28: 881–884). The interim data of two randomized placebo controlled trials in patients ( = 47) meeting WHO criteria for dengue hemorrhagic fever (DHF) with severe thrombocytopenia (platelets ≤ 50,000/mm) reveal that the increase in platelet count with anti-D immune globulin (WinRho® SDF), 50 μg/kg (250 IU/kg) intravenously is more brisk than the placebo group. The mean maximum platelet count of the anti-D–treated group at 48 hours was 91,500/mm compared with 69,333/mm in the placebo group. 75% of the anti-D–treated group demonstrated an increase of platelet counts ≥ 20,000 compared with only 58% in the placebo group. These data suggest that treatment of severe thrombocytopenia accompanying DHF with anti-D may be a useful and safe therapeutic option.


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  • Received : 01 Sep 2006
  • Accepted : 09 Dec 2006
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