1921
Volume 76, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A cross-sectional serosurvey using ELISA was performed on 445 cats living in ecoregions around the Northwestern Mediterranean basin; 58 cats from an area of the US where leishmaniasis is not endemic were used as negative controls. ELISA results were further confirmed in 69 cats by Western blot (WB). Finally, 76 of them were also tested for FeLV and FIV. Seroprevalence by ELISA-prot A was 6.29%, and that by ELISA-IgG was 5.25%. Positive cat sera recognized patterns of polypeptides in WB, including -specific antigenic fractions. There was no association with retroviruses. -specific antibodies are prevalent in cats living in ecoregions around the Northwestern Mediterranean basin; thus, leishmaniasis must be included in the differential diagnosis of diseases in cats living in these ecoregions. Their role as peridomestic reservoirs for needs further characterization, but it could be hypothesized that the cat is a secondary reservoir host, rather than an accidental one.

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2007-04-01
2017-03-25
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References

  1. World Health Organization, 2002. Annex 3: Burden of Disease in DALYs by Cause, Sex and Mortality Stratum in WHO Regions, Estimates for 2001. The World Health Report. Geneva: WHO, 192–197.
  2. Solano-Gallego L, Morell P, Arboix M, Alberola J, Ferrer L, 2001. Prevalence of Leishmania infantum infection in dogs living in an area of canine leishmaniasis endemicity using PCR on several tissues and serology. J Clin Microbiol 39 : 560–563.
  3. Bongiorno G, Habluetzel A, Khoury C, Maroli M, 2003. Host preferences of phlebotomine sand flies at a hypoendemic focus of canine leishmaniasis in central Italy. Acta Trop 88 : 109–116.
  4. Gramiccia M, Maazoun R, Lanotte G, Rioux JA, Leblanco S, Evans DA, Peters W, Bettini S, Gradoni L, Pozio E, 1982. Enzymatic typing of 11 isolates of Leishmania collected from visceral infections in rodents, dogs and foxes on the Italian mainland: demonstration of an enzyme variant in the parasite of the fox (Vulpes vulpes) and dog. Ann Parasitol Hum Comp 57 : 527–531.
  5. Abranches P, Silva FMC, Ribeiro MMS, Lopes FJ, Gomes LT, 1983. Kala-Azar in Portugal. 4. The wild reservoir—the Isolation of a Leishmania from a fox. Trans R Soc Trop Med Hyg 77 : 420–421.
  6. González-Castro J, Morillas-Márquez F, Benavides-Delgado I, 1987. Leishmania infantum s. str., parasite du rat noir (Rattus rattus). A propos du typage enzymatique d’une souche isolée en Espagne, dans la province de Grenade. Ann Parasitol Hum Comp 62 : 101.
  7. Koehler K, Stechele M, Hetzel U, Domingo M, Schonian G, Zahner H, Burkhardt E, 2002. Cutaneous leishmaniosis in a horse in southern Germany caused by Leishmania infantum. Vet Prasitol 109 : 9–17.
  8. Ozon C, Marty P, Pratlong F, Breton C, Blein M, Lelievre A, Haas P, 1998. Disseminated feline leishmaniosis due to Leishmania infantum in southern France. Vet Parasitol 75 : 273–277.
  9. Sergent E, Sergent E, Lombard J, Quilichini M, 1912. La leishmaniose à Alger. Infection simultanée d’un enfant, d’un chien et d’un chat dans la même habitation. Bull Soc Pathol Exot 5 : 93–98.
  10. Dunan S, Mary C, Garbe L, Breton Y, Olivon B, Ferrey P, Cabassus JP, 1989. A propos d’un cas de leishmaniose chez un chat de la région marsiellaise. Bull Soc Française Parasitol 7 : 17–20.
  11. Hervas J, Chacon-M De Lara F, Sanchez-Isarria MA, Pellicer S, Carrasco L, Castillo JA, Gomez-Villamandos JC, 1999. Two cases of feline visceral and cutaneous leishmaniosis in Spain. J Feline Med Surg 1 : 101–105.
  12. Poli A, Abramo F, Barsotti P, Leva S, Gramiccia M, Ludovisi A, Mancianti F, 2002. Feline leishmaniosis due to Leishmania infantum in Italy. Vet Parasitol 106 : 181–191.
  13. Pennisi MG, Venza M, Reale S, Vitale F, Lo Giudice S, 2004. Case report of leishmaniasis in four cats. Vet Res Commun 28 (Suppl 1): 363–366.
  14. Rufenacht S, Sager H, Muller N, Schaerer V, Heier A, Welle MM, Roosje PJ, 2005. Two cases of feline leishmaniosis in Switzerland. Vet Rec 156 : 542–545.
  15. Denuzière C, 1977. Un chat leishmanien. Sem Vet 32 : 1–2.
  16. Laurelle Magalon C, Toga I, 1996. Un cas de leishmaniose féline. Pract Med Chir Animal Comp 31 : 261–266.
  17. Hervas J, de Lara FCM, Lopez J, Gomez-Villamandos JC, Guerrero MJ, Moreno A, 2001. Granulomatous (pseudotumoral) iridociclitis associated with leishmaniasis in a cat. Vet Rec 149 : 624–625.
  18. Leiva M, Lloret A, Pena T, Roura X, 2005. Therapy of ocular and visceral leishmaniasis in a cat. Vet Ophthalmol 8 : 71–75.
  19. Kirkpatrick CE, Farrell JP, Goldschmidt MH, 1984. Leishmania chagasi and L. donovani: experimental infections in domestic cats. Exp Parasitol 58 : 125–131.
  20. Mancianti F, 2004. Feline leishmaniasis: what’s the epidemiological role of the cat? Parasitologia 46 : 203–206.
  21. Bez M, 1992. La Leishmaniose chez le Chat. Enquete Seroepidemiologique dans les Alpes-Maritimes. Doctoral thesis. Lyon: Ecole Nationale Veterinaire de Lyon.
  22. Marechal M, 1993. La Leishmaniose Feline: Cas Sporadique ou Réalité Ignorée? (Étude dans la Région Marseillaise). Doctoral thesis. Lyon: Ecole Nationale Veterinaire de Lyon.
  23. Pennisi MG, Masucci M, Catarsini O, 1998. Presenza d’anticorpi anti-Leishmania in gatti FIV che vivono in zona endemica. Atti Soc Ital Sci Vet 52 : 265–266.
  24. Ozon C, Marty P, Lelievre A, Biorgalli J, Corniglion A, Giacomo A, Lamothe J, 1999. Le chat reservoir de Leishmania infantum dans le sud de la France? Proceedings of the 24th WSAVA Congress. Lyon.
  25. Pennisi MG, Maxia L, Vitale F, Massucci M, Borruto G, Caracappa S, 2000. Studio dell’infezione de Leishmania mediante PCR in gatti che vivono in zona endemica. Atti Soc Ital Sci Vet 54 : 215–216.
  26. Portús M, Gàllego M, Riera C, Aisa MJ, Fisa R, Castillejo S, 2002. Wild and domestic mammals in the life cycle of Leishmania infantum in Southwest Europe. A literature review and studies performed in Catalonia (Spain). Rev Iber Parasitol 62 : 72–76.
  27. Vita S, Santori D, Aguzzi I, Petrotta E, Luciani A, 2005. Feline leishmaniasis and ehrlichiosis: serological investigation in Abruzzo region. Vet Res Commun 29 (Suppl 2): 319–321.
  28. Riera C, Valladares JE, Gallego M, Aisa MJ, Castillejo S, Fisa R, Ribas N, Carrio J, Alberola J, Arboix M, 1999. Serological and parasitological follow-up in dogs experimentally infected with Leishmania infantum and treated with meglumine antimoniate. Vet Parasitol 84 : 33–47.
  29. Aisa MJ, Castillejo S, Gallego M, Fisa R, Riera MC, De Colmenares M, Torras S, Roura X, Sentis J, Portus M, 1998. Diagnostic potential of Western blot analysis of sera from dogs with leishmaniasis in endemic areas and significance of the pattern. Am J Trop Med Hyg 58 : 154–159.
  30. Mary C, Lamouroux D, Dunan S, Quilici M, 1992. Western-Blot analysis of antibodies to Leishmania infantum antigens: potential of the 14-kD and 16-kD antigens for diagnosis and epidemiologic purposes. Am J Trop Med Hyg 47 : 764–771.
  31. Fisa R, Gállego M, Castillejo S, Aisa MJ, Serra T, Riera C, Carrio J, Gallego J, Portus M, 1999. Epidemiology of canine leishmaniosis in Catalonia (Spain): the example of the Priorat focus. Vet Parasitol 83 : 87–97.
  32. Ben Said M, Jaiem A, Smoorenburg M, Semiao-Santos SJ, Ben Rachid MS, el Harith A, 1992. Canine leishmaniasis in the region of Enfidha (Central Tunisia). Assessment of seroprevalence with direct agglutination (DAT) and indirect immunofluorescence (IFAT). Bull Soc Pathol Exot 85 : 159–163.
  33. Berrahal F, Mary C, Roze M, Berenger A, Escoffier K, Lamouroux D, Dunan S, 1996. Canine leishmaniasis: identification of asymptomatic carriers by polymerase chain reaction and immunoblotting. Am J Trop Med Hyg 55 : 273–277.
  34. Solano-Gallego L, Llull J, Ramos G, Riera C, Arboix M, Alberola J, Ferrer L, 2000. The Ibizian hound presents a predominantly cellular immune response against natural Leishmania infection. Vet Parasitol 90 : 37–45.
  35. Cabral M, O’Grady JE, Gomes S, Sousa JC, Thompson H, Alexander J, 1998. The immunology of canine leishmaniosis: strong evidence for a developing disease spectrum from asymptomatic dogs. Vet Parasitol 76 : 173–180.
  36. Alvar J, Canavate C, Gutierrez Solar B, Jimenez M, Laguna F, Lopez Velez R, Molina R, Moreno J, 1997. Leishmania and human immunodeficiency virus coinfection: the first 10 years. Clin Microbiol Rev 10 : 298–319.
  37. Fernandez-Bellon H, Solano-Gallego L, Bardagi M, Alberola J, Ramis A, Ferrer L, 2005. Immune response to Leishmania infantum in healthy horses in Spain. Vet Parasitol 135 : 181–185.
  38. Guy MW, Killickkendrick R, Gill GS, Rioux JA, Bray RS, 1984. Ecology of Leishmaniasis in the south of France. 19. Determination of the hosts of Phlebotomus ariasi Tonnoir, 1921 in Cevennes by bloodmeal analyses. Ann Parasitol Hum Comp 59 : 449–458.
  39. Ogusuku E, Perez JE, Paz L, Nieto E, Monje J, Guerra H, 1994. Identification of bloodmeal sources of Lutzomyia spp. in Peru. Ann Trop Med Parasitol 88 : 329–335.
  40. De Colmenares M, Portús M, Botet J, Dobano C, Gàllego M, Wolff M, Seguí G, 1995. Identification of blood meals of Phlebotomus perniciosus (Diptera: Psychodidae) in Spain by a competitive enzyme-linked immunosorbent assay, biotin/avidin method. J Med Entomol 32 : 229–233.
  41. Ashford RW, 2000. The leishmaniases as emerging and reemerging zoonoses. Int J Parasitol 30 : 1269–1281.
  42. Gramiccia M, Gradoni L, 2005. The current status of zoonotic leishmaniases and approaches to disease control. Int J Parasitol 35 : 1169–1180.
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  • Received : 29 Mar 2006
  • Accepted : 21 Oct 2006

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