Volume 76, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We report the first case of disseminated intravascular coagulation (DIC) complicated by peripheral gangrene induced by in rhesus monkeys. Ten days after experimental challenge, numerous petechiae were noted over the trunk and extremities, with polychromasia, severe anemia, thrombocytopenia, and moderate parasitemia. These changes were accompanied by elevated serum activity of blood urea nitrogen, creatinine, transaminases, and creatinine phosphokinase. The animal received intravenous fluid support, artemether, and blood transfusion. Three days after treatment, the platelet counts returned to normal, and parasitemia was abated. However, several areas of skin discoloration with gangrenous tissue in the hands and the tail were observed. Coagulation profile showed elevated D-dimers and elevated levels of fibrinogen/fibrin degradation products with low levels of protein S functional activity. DIC with peripheral gangrene is very rare in -infected individuals. Our results indicate that the experimental model of infection of rhesus monkeys is important for studies of malarial anemia and coagulopathy.


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  • Received : 09 Oct 2006
  • Accepted : 26 Dec 2006

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