Volume 76, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Vaccinating with soluble promastigote exogenous antigens (SEAgs) protects mice against challenge with . To explore the potential of SEAgs to cross-protect against infection with other species of , BALB/c mice were immunized with SEAgs prior to challenge with either or promastigotes. Such mice were protected against but not infection. –infected mice developed lesions that were not significantly different from those of controls and that contained 13-fold more parasites. In contrast, immunized mice infected with were protected as illustrated by low splenic parasite loads (as much as 4,913-fold fewer parasites). This protection corresponded to significant increases in gamma interferon and low production of interleukin-4 (IL-4) IL-4 or IL-10, which suggested an enhanced type 1 response.


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  • Received : 18 Jul 2006
  • Accepted : 27 Nov 2006

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