Volume 76, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Few studies have compared ivermectin directly with topical agents in developing countries. We compared the effectiveness of oral ivermectin (200 μg/kg) with topical 25% benzyl benzoate and monosulfiram soap in 210 subjects of age 5 to 65 years with scabies. Subjects with persistent lesions after 2 weeks received a second course of treatment. All lesions had resolved after 2 weeks in 77 of 98 (79%) subjects treated with ivermectin and in 60 of 102 (59%) subjects treated topically ( = 0.003). The improvement in severity score was greater in the ivermectin group than in the topical treatment group ( < 0.001). The overall cure rate after 4 weeks was 95% in the ivermectin group and 86% in the topical treatment group ( = 0.04). Compared with topical benzyl benzoate and monosulfiram in the treatment of scabies, ivermectin was at least as effective and led to more rapid improvement.


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  • Received : 28 Mar 2006
  • Accepted : 02 Nov 2006

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