1921
Volume 76, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Bangladesh faces increasing levels of chloroquine resistance, and drug sensitivity to sulfadoxine-pyremethamine is already compromised. Therefore, the Ministry of Health recently changed the national treatment guidelines to artemisinin-based combination therapies. The purpose of this study was to determine the baseline therapeutic efficacy of artemether-lumefantrine used as a six-dose regimen for the treatment of uncomplicated malaria. Sixty-seven patients were enrolled in the study; the cure rate in a 42-day follow-up after an adjustment by polymerase chain reaction was 94.3%. The treatment led to rapid fever (mean ± SD = 25.82 ± 12.14 hours) and parasite (30.36 ± 19.43 hours) clearance. These data suggest that artemether-lumefantrine is a highly efficacious and well-tolerated treatment for uncomplicated malaria in Bangladesh.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2007.76.39
2007-01-01
2017-09-23
Loading full text...

Full text loading...

/deliver/fulltext/14761645/76/1/0760039.html?itemId=/content/journals/10.4269/ajtmh.2007.76.39&mimeType=html&fmt=ahah

References

  1. World Health Organization, 2005. World Malaria Report. Cited April 3, 2006. Available from http://rbm.who.int/wmr2005/profiles/bangladesh.pdf
  2. Rahman MR, Hassan MR, Faiz MA, Paul B, Jalil MA, 1998. Monitoring efficacy of commonly used antimalarials by a 14-day in-vivo test in a new settler’s camp in endemic zone at Cox’s Bazar. Bangladesh Med Res Counc Bull 24 : 67–74.
  3. Rahman MR, Paul DC, Rashid M, Ghosh A, Bangali AM, Jalil MA, Faiz MA, 2001. A randomized controlled trial on the efficacy of alternative treatment regimens for uncomplicated falciparum malaria in a multi-drug resistant falciparum area of Bangladesh – narrowing the options for the National Malaria Control Programme? Trans R Soc Trop Med Hyg 95 : 661–667.
  4. Noedl H, Faiz MA, Yunus EB, Rahman MR, Hossain MA, Samad R, Miller RS, Pang LW, Wongsrichanalai C, 2003. Drug-resistant malaria in Bangladesh: an in vitro assessment. Am J Trop Med Hyg 68 : 140–142.
  5. World Health Organization, 2003. Assessment and Monitoring of Antimalarial Drug Efficiency for the Treatment of Uncomplicated Falciparum Malaria. Geneva: World Health Organization. Document WHO/HTM/RBM/2003.50
  6. Van den Broeck IV, van der Wardt S, Talukder L, Chakma S, Brockman A, Nair S, Anderson TC, 2004. Drug resistance in Plasmodium falciparum from the Chittagong Hill Tracts, Bangladesh. Trop Med Int Health 9 : 680–687.
  7. Thriemer K, Haque R, Wagatsuma Y, Salam MA, Akther S, Attlmayr B, Fukuda M, Schaecher K, Miller RS, Noedl H, 2006. Therapeutic efficacy of quinine plus sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Bangladesh. Am J Trop Med Hyg 75 : 645–649.
  8. Ezzet F, van Vugt M, Nosten F, Looareesuwan S, White NJ, 2000. Pharmacokinetics and pharmacodynamics of lumefantrine (benflumetol) in acute falciparum malaria. Antimicrob Agents Chemother 44 : 697–704.
  9. Van Vugt M, Wilairatana P, Gemperli B, Gathmann I, Phaipun L, Brockman A, Luxemburger C, White NJ, Nosten F, Looareesuwan S, 1999. Efficacy of six doses of artemether-lumefantrine (benflumetol) in multidrug-resistant falciparum malaria. Am J Trop Med Hyg 60 : 936–942.
  10. Van Vugt M, Brockman A, Gemperlli B, Luxemburger C, Gathmann I, Royce C, Slight T, Looareesuwan S, White NJ, Nosten F, 1998. Randomized comparison of artemether-benflumetol and artesunate-mefloquine in treatment of multidrug-resistant falciparum malaria. Antimicrob Agents Chemother 42 : 135– 139.
  11. Van Vugt M, Looareesuwan S, Wilairatana P, McGready R, Villegas L, Gathmann I, Mull R, Brockman A, White NJ, Nosten F, 2000. Artemether-lumefantrine for the treatment of multi-drug-resistant falciparum malaria. Trans R Soc Trop Med Hyg 94 : 545–548.
  12. Stohrer JM, Dittrich S, Thongpaseuth V, Vanisaveth V, Phetsouvanh R, Phompida S, Monti F, Christophel EM, Lindegardh N, Annerberg A, Jelinek T, 2004. Therapeutic efficacy of artemether-lumefantrine and artesunate-mefloquine for treatment of uncomplicated Plasmodium falciparum malaria in Luang Namtha Province, Lao People’s Democratic Republic. Trop Med Int Health 9 : 1175–1183.
  13. Hutagalung R, Paipun L, Ashley EA, McGready R, Brockman A, Thwai KL, Singhasivanon P, Jelinek T, White NJ, Nosten FH, 2005. A randomized trial of artemether-lumefantrine versus mefloquine-artesunate for the treatment of uncomplicated multi-drug resistant Plasmodium falciparum on the western border of Thailand. Malar J 22 : 46.
  14. Van den Broek IV, Maung UA, Peters A, Liem L, Kamal M, Rahman M, Rahman MR, Bangali AM, Das S, Barends M, Faiz AM, 2005. Efficacy of chloroquine + sulfadoxine-pyrimethamine, mefloquine + artesunate and artemether + lumefantrine combination therapies to treat Plasmodium falciparum malaria in the Chittagong Hill Tracts, Bangladesh. Trans R Soc Trop Med Hyg 99 : 727–735.
  15. Adjuik M, Babiker A, Garner P, Olliaro P, Taylor W, White N, International Artemisinin Study Group, 2004. Artesunate combination for treatment of malaria: meta-analysis. Lancet 363 : 9–17.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.76.39
Loading
  • Received : 25 Jul 2006
  • Accepted : 07 Sep 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error