1921
Volume 76, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The contribution of interferon-γ (IFN-γ) to immunity from amebiasis was assessed in a three-year prospective study of children 2–5 years of age in an urban slum of Dhaka, Bangladesh. IFN-γ produced by peripheral blood mononuclear cells stimulated with soluble amebic antigen was measured upon enrollment. Thirty-one of the 209 enrolled children had –associated diarrhea. Children who produced higher than the median level of IFN-γ (median = 580 pg/mL) had longer survival without diarrhea/dysentery (log rank test = 0.03) and a reduction in the risk of diarrhea/dysentery by more than half (Cox proportional hazard regression = 0.45, = 0.04). When adjusted for stunting, the association between IFN-γ and the time to the first episode of -associated diarrhea remained marginally significant (Cox proportional hazard regression = 0.49, = 0.07). We conclude that production of IFN-γ is linked to nutritional status and predicts future susceptibility to symptomatic amebiasis.

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2007-02-01
2017-11-18
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  • Received : 13 Sep 2006
  • Accepted : 17 Oct 2006

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