1921
Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

An outbreak of Chikungunya virus (CHIKV) illness associated with high fever combined with prolonged and severe arthralgias occurred on Grande Comore Island from January through May 2005; 5,202 cases were reported. A seroprevalence study was conducted to define the extent of transmission on the island. We conducted a cross-sectional survey using a multistage sampling technique. A total of 481 households were sampled. In each household, one resident was selected randomly for interview and blood collection. We administered questionnaires and tested 331 sera for CHIKV-specific IgM and IgG antibodies by capture enzyme-linked immunosorbent assay. Infection with CHIKV infection (seropositivity) was defined as presence of IgG and/or IgM antibodies to CHIKV. A total of 331 (69%) of 481 survey participants consented to blood collection. Antibodies to CHIKV were detected in 63% of sera; IgM antibodies were found in 60% of specimens and IgG antibodies were detected in 27% of specimens. Extrapolation of the findings to the entire Grande Comore population suggested that nearly 215,000 people were infected with CHIKV during the outbreak. A total of 79% of the seropositive persons were hospitalized or stayed at home in bed for a mean of 6 days (range = 1–30 days); 52% missed work or school for a mean of 7 days (range = 1–40 days). The findings suggest that CHIKV was broadly transmitted during the outbreak with a high attack rate. Although not fatal during this outbreak, CHIKV infection caused significant morbidity and decreased economic productivity.

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References

  1. Pastorino B, Muyembe-Tamfum JJ, Bessaud M, Tock F, Tolou H, Durand JP, 2004. Epidemic resurgence of Chikungunya virus in Democratic Republic of the Congo: identification of a new central African strain. J Med Virol 74 : 277–282. [Google Scholar]
  2. Lumsden WH, 1955. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53, II. General description and epidemiology. Trans R Soc Trop Med Hyg 49 : 33–57. [Google Scholar]
  3. Powers AM, Brault AC, Tesh RB, Weaver SC, 2000. Re-emergence of Chikungunya and O’nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol 81 : 471–479. [Google Scholar]
  4. Tesh RB, 1982. Arthritides caused by mosquito-borne viruses. Annu Rev Med 33 : 31–40. [Google Scholar]
  5. Jupp P, McIntosh B, 1988. Chikungunya virus disease. Monath T, ed. The Arboviruses: Epidemiology and Ecology. Boca Raton, FL: CRC Press: 137–157.
  6. Jeandel P, Josse R, Bagambisa G, Durand JP, 2004. Exotic viral arthritis: role of alphaviruses. Med Trop (Mars) 64 : 81–88. [Google Scholar]
  7. Robinson MC, 1955. An epidemic of virus disease in Southern Province, Tanganyika Territory, in 1952–53, I. Cinical features. Trans R Soc Trop Med Hyg 49 : 28–32. [Google Scholar]
  8. Lam SK, Chua KB, Hooi PS, Rahimah MA, Kumari S, Tharma-ratnam M, 2001. Chikungunya infection: an emerging disease in Malaysia. Southeast Asian J Trop Med Public Health 32 : 447–451. [Google Scholar]
  9. Laras K, Sukri NC, Larasati RP, Bangs MJ, Kosim R, Djauzi, Wandra T, Master J, Kosasih H, Hartati S, Beckett C, Sedya-ningsih ER, Beecham HJ III, Corwin AL, 2005. Tracking the re-emergence of epidemic chikungunya virus in Indonesia. Trans R Soc Trop Med Hyg 99 : 128–141. [Google Scholar]
  10. Thonnon J, Spiegel A, Diallo M, Diallo A, Fontenille D, 1999. Chikungunya virus outbreak in Senegal in 1996 and 1997. Bull Soc Pathol Exot 92 : 79–82. [Google Scholar]
  11. ProMED-mail, Chikungunya - Mauritius and Reunion Island. ProMED-mail 2005; May 19, 2006: 20050519.1372. Accessed January 14, 2007. Available from http://www.promedmail.org
  12. ProMED-mail, Chikungunya - Indian Ocean update (09): islands, India. ProMED-mail; March 20, 2006: 20060320.0864. Accessed January 15, 2007. Available from http://www.promedmail.org
  13. ProMED-mail, Chikungunya - Seychelles. ProMED-mail 2006; February 3, 2006: 20060203.0352. Accessed January 15, 2007. Available from http://www.promedmail.org
  14. ProMED-mail, Chikungunya - Madagascar: suspected, request for information. ProMED-mail 2006; Feb 2, 2007: 20060202.0340. Accessed January 14, 2007. Available from http://www.promedmail.org
  15. Morril JC, Johnson BK, Hyams C, Okoth F, Tukei PM, Mugambi M, Woody J, 1991. Serological evidence of arboviral infections among humans of coastal Kenya. J Trop Med Hyg 94 : 166–168. [Google Scholar]
  16. Neogi DK, Bhattacharya N, Mukhefee KK, Chakraborty MS, Banerjee P, Mitra K, 1995. Serosurvey of chikungunya antibody in Calcutta metropolis. J Commun Dis 27 : 19–22. [Google Scholar]
  17. Padbidri VS, Wairagkar NS, Joshi GD, 2002. A serological survey of arboviral diseases among the human population of the An-daman and Nicobar Islands, India. Southeast Asian J Trop Med Public Health 33 : 794–800. [Google Scholar]
  18. Halstead SB, Scanlon JE, Umpaivit P, Udomsakdi S, 1969. Dengue and Chikungunya virus infection in man in Thailand, 1962–1964. IV. Epidemiologic studies in the Bangkok metropolitan area. Am J Trop Med Hyg 18 : 997–1021. [Google Scholar]
  19. Vanlandingham DL, Hong C, Klingler K, 2005. Differential infectivities of O’nyong-nyong and Chikungunya virus isolates in Anopheles gambiae and Aedes aegypti mosquitoes. Am J Trop Med Hyg 72 : 616–621. [Google Scholar]
  20. Johnson BK, 1988. O’nyong’nyong virus disease. Monath TP, ed. The Arboviruses: Epidemiology and Ecology. Boca Raton, FL: CRC Press: 217–223.
  21. Vezzani D, Velazquez SM, Schweigmann N, 2004. Control of Aedes aegypti with temephos in a Buenos Aires cemetery, Ar-gentina. Rev Saude Publica 38 : 738–740. [Google Scholar]
  22. Kay B, Vu SN, 2005. New strategy against Aedes aegypti in Viet-nam. Lancet 365 : 551–552. [Google Scholar]
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  • Received : 08 Sep 2006
  • Accepted : 21 Feb 2007

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