1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 76, Issue 6
  4. Article
Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

We have previously shown that female DBA/2 mice are significantly more resistant to compared with males. Here, we have analyzed the effect of 17β-estradiol (E) on function and cytokine production in male and female DBA/2 macrophages . We show that E increases NO production and parasite killing in infected male and female DBA/2 macrophages without increasing production of pro-inflammatory cytokines. These data indicate that E may enhance leishmanicidal activity in macrophages by directly regulating production of NO.

Copyright 2007 The American Society of Tropical Medicine
Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2007.76.1125
2007-06-01
2018-08-14

  • From This Site

    /content/journals/10.4269/ajtmh.2007.76.1125
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/76/6/0761125.html?itemId=/content/journals/10.4269/ajtmh.2007.76.1125&mimeType=html&fmt=ahah

References

  1. Miller L, Hunt JS, 1996. Sex steroid hormones and macrophage function. Life Sci 59 : 1–14.
  2. Gulshan S, McCruden AB, Stimson WH, 1990. Oestrogen receptors in macrophages. Scand J Immunol 31 : 691–697.
  3. Carbone A, Piantelli M, Musiani P, Larocca LM, Aiello FB, Maggiano N, Scoppetta C, Crucitti F, Ranelletti FO, 1986. Estrogen binding sites in peripheral blood mononuclear cells and thymocytes from 2 myasthenia gravis patients. J Clin Lab Immunol 21 : 87–91.
  4. Stimson WH, 1988. Oestrogen and human T lymphocytes: presence of specific receptors in the T-suppressor/cytotoxic subset. Scand J Immunol 28 : 345–350.
  5. Danel L, Menouni M, Cohen JH, Magaud JP, Lenoir G, Revillard JP, Saez S, 1985. Distribution of androgen and estrogen receptors among lymphoid and haemopoietic cell lines. Leuk Res 9 : 1373–1378.
  6. Satoskar A, Alexander J, 1995. Sex-determined susceptibility and differential IFN-gamma and TNF-alpha mRNA expression in DBA/2 mice infected with Leishmania mexicana. Immunology 84 : 1–4.
  7. Lezama-Davila CM, Isaac-Marquez AP, 2006. Systemic cytokine response in humans with Chiclero’s ulcers. Parasitol Res 99 : 546–553.
  8. Lezama-Davila CM, Oghumu S, Satoskar AR, Isaac-Marquez AP, 2007. Sex-associated susceptibility in humans with Chiclero’s ulcer: resistance in females is associated with increased serum-levels of GM-CSF. Scand J Immunol 65 : 210–211.
  9. Shanker G, Sorci-Thomas M, Adams MR, 1994. Estrogen modulates the expression of tumor necrosis factor alpha mRNA in phorbol ester-stimulated human monocytic THP-1 cells. Lymphokine Cytokine Res 13 : 377–382.
  10. Chao TC, Van Alten PJ, Greager JA, Walter RJ, 1995. Steroid sex hormones regulate the release of tumor necrosis factor by macrophages. Cell Immunol 160 : 43–49.
  11. Cutolo M, Villaggio B, Seriolo B, Montagna P, Capellino S, Straub RH, Sulli A, 2004. Synovial fluid estrogens in rheumatoid arthritis. Autoimmun Rev 3 : 193–198.
  12. Yang L, Hu Y, Hou Y, 2006. Effects of 17beta-estradiol on the maturation, nuclear factor kappa B p65 and functions of murine spleen CD11c-positive dendritic cells. Mol Immunol 43 : 357–366.
  13. Rodriguez-Sosa M, Monteforte GM, Satoskar AR, 2001. Susceptibility to Leishmania mexicana infection is due to the inability to produce IL-12 rather than lack of IL-12 responsiveness. Immunol Cell Biol 79 : 320–322.
  14. You HJ, Kim JY, Jeong HG, 2003. 17-beta-Estradiol increases inducible nitric oxide synthase expression in macrophages. Biochem Biophys Res Commun 303 : 1129–1134.
  15. Garbán HJ, Márquez-Garbán DC, Pietras R, Ignarro LJ, 2005. Rapid nitric oxide-mediated S-nitrosylation of estrogen receptor: regulation of estrogen-dependent gene transcription. Proc Natl Acad Sci USA 102 : 2632–2636.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2007.76.1125
Loading
17β-ESTRADIOL INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES
The American Journal of Tropical Medicine and Hygiene 76, 1125 (2007); https://doi.org/10.4269/ajtmh.2007.76.1125
/content/journals/10.4269/ajtmh.2007.76.1125
/content/journals/10.4269/ajtmh.2007.76.1125
Loading

Data & Media loading...

  • Received : 03 Nov 2006
  • Accepted : 27 Feb 2007

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error