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- The American Society of Tropical Medicine and Hygiene
- Source: The American Journal of Tropical Medicine and Hygiene, Volume 76, Issue 6, Jun 2007, p. 1125 - 1127
f 17β-ESTRADIOL INCREASES LEISHMANIA MEXICANA KILLING IN MACROPHAGES FROM DBA/2 MICE BY ENHANCING PRODUCTION OF NITRIC OXIDE BUT NOT PRO-INFLAMMATORY CYTOKINES
Abstract
We have previously shown that female DBA/2 mice are significantly more resistant to Leishmania mexicana compared with males. Here, we have analyzed the effect of 17β-estradiol (E2) on function and cytokine production in male and female DBA/2 macrophages in vitro. We show that E2 increases NO production and parasite killing in L. mexicana-infected male and female DBA/2 macrophages without increasing production of pro-inflammatory cytokines. These data indicate that E2 may enhance leishmanicidal activity in macrophages by directly regulating production of NO.
Copyright 2007 The American Society of Tropical Medicine
- 03 Nov 2006
- 27 Feb 2007