Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Genetic strategies for controlling malaria transmission based on engineering pathogen resistance in mosquitoes are being tested in a number of animal models. A key component is the effector molecule and the efficiency with which it reduces parasite transmission. Single-chain antibodies (scFvs) that bind the circumsporozoite protein of the avian parasite, , can reduce mean intensities of sporozoite infection of salivary glands by two to four orders of magnitude in transgenic . Significantly, mosquitoes with as few as 20 sporozoites in their salivary glands are infectious for a vertebrate host, . Although scFvs hold promise as effector molecules, they will have to reduce mean intensities of infection to zero to prevent parasite transmission and disease. We conclude that similar endpoints must be reached with human pathogens if we are to expect an effect on disease transmission.


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  • Received : 12 Dec 2006
  • Accepted : 31 Jan 2007

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