1921
Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Helminth infections are prevalent in malaria-endemic areas, yet the potential for helminths to alter malaria transmission has not been closely examined. We used the murine model of co-infection to assess the impact of helminth co-infection on malaria transmission. In four replicate experiments, mosquitoes exposed to co-infected mice five days post-malaria infection had a higher rate of infectivity (80.1%, n = 241) than those exposed to malaria only–infected mice (72.0%, n = 232, = 0.039). Intensity of malaria parasite transmission was also greater, with approximately two-fold more oocysts (geometric mean = 19.2 versus 10.5, = 0.004) and an increase in sporozoite burden observed in mosquitoes exposed to co-infected mice. Malaria parasite prevalence and anemia were similar between co-infected and malaria only–infected mice, which suggested that enhanced malaria parasite transmission was due to helminth-induced modulation of host responses.

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2007-06-01
2017-09-25
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  • Received : 16 Nov 2006
  • Accepted : 13 Feb 2007

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