1921
Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

A major mechanism for the generation allelic diversity in the gene is meiotic recombination in the mosquito. The frequency of recombination events is dependent on the intensity of transmission. Herein we investigate the frequency of recombination-driven allelic diversity and temporal variation of in Rufiji, eastern coastal Tanzania, where malaria transmission is intense. We identified 5′ recombinant types, 3′ sequence types, and haplotypes (unique associations of 5′ recombinant types and 3′ sequence types) to measure the extent and temporal variation of allelic diversity. The results show that haplotype diversity is higher in Tanzania as compared with areas with lower transmission rates. The frequencies of individual polymorphic regions/sites remained stable during the study period. However, the frequency distribution of haplotypes varied between 1993 and 1998. These results suggest that frequent recombination events between alleles intermittently generate novel alleles in high transmission areas.

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2007-06-01
2017-11-22
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  • Received : 31 Oct 2006
  • Accepted : 11 Dec 2006

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