1921
Volume 76, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Sensitivity of populations from Colombia ( = 38) and Tanzania ( = 45) to the newly developed, fully synthetic peroxide OZ277 was investigated using a standard isotopic microtest. OZ277 showed excellent activity against chloroquine-resistant isolates in Colombia with median IC [range] values of 2.5 ng/mL [0.34–8] (4.4 nM [0.6–14]) and Tanzania with 1.5 ng/mL [0.22–10] (2.65 nM [0.4–17.7]). The potency of OZ277 was similar to artesunate, showing median IC values of 1.5 ng/mL [0.42–8.6] (3.8 nM [1.1–22.3]) and 1.8 ng/mL [0.2–10] (4.7 nM [0.5–26.04]) in Colombia and Tanzania, respectively. These results support the development of this new antimalarial compound.

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2007-06-01
2017-09-23
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  • Received : 04 Sep 2006
  • Accepted : 04 Nov 2006

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