Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Susceptibility to infection and subsequent arthritis is genetically determined in mice and determined by innate immunity. Accordingly, macrophage responses to challenge may differ between mouse strains. Bone marrow–derived macrophages were infected with clonal strain N40. Interleukin-12 and tumor necrosis factor-α (TNF-α) production were higher in macrophages from resistant C57Bl/6 mice than in macrophages from susceptible C3H/HeJ mice. However, TNF-α production was observed in lower concentrations in C3H/HeJ (toll-like receptor-4) macrophages than in C3H/FeJ (TLR4) macrophages, suggesting that TLR4 might contribute to the response to . A higher cytokine response to was associated with cell death in macrophages from resistant C57Bl/6 mice. Understanding variability in the response of macrophages to may contribute to understanding Lyme arthritis.


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  • Received : 03 May 2006
  • Accepted : 23 Jun 2006

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