1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 75, Issue 5
  4. Article
Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

Susceptibility to infection and subsequent arthritis is genetically determined in mice and determined by innate immunity. Accordingly, macrophage responses to challenge may differ between mouse strains. Bone marrow–derived macrophages were infected with clonal strain N40. Interleukin-12 and tumor necrosis factor-α (TNF-α) production were higher in macrophages from resistant C57Bl/6 mice than in macrophages from susceptible C3H/HeJ mice. However, TNF-α production was observed in lower concentrations in C3H/HeJ (toll-like receptor-4) macrophages than in C3H/FeJ (TLR4) macrophages, suggesting that TLR4 might contribute to the response to . A higher cytokine response to was associated with cell death in macrophages from resistant C57Bl/6 mice. Understanding variability in the response of macrophages to may contribute to understanding Lyme arthritis.

Copyright 2006 The American Society of Tropical Medicine
Loading

Article metrics loading...

The graphs shown below represent data from March 2017
/content/journals/10.4269/ajtmh.2006.75.964
2006-11-01
2019-01-20

  • From This Site

    /content/journals/10.4269/ajtmh.2006.75.964
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/75/5/0750964.html?itemId=/content/journals/10.4269/ajtmh.2006.75.964&mimeType=html&fmt=ahah

References

  1. Barthold SW, 1996. Lyme borreliosis in the laboratory mouse. J Spirochetal Tick-Borne Dis 3 : 22–44. [Google Scholar]
  2. Yang L, Weis JH, Eichwald E, Kolbert CP, Persing DH, Weis JJ, 1994. Heritable susceptibility to severe Borrelia burgdorferi-induced arthritis is dominant and is associated with persistence of large numbers of spirochetes in tissues. Infect Immun 62 : 492–500. [Google Scholar]
  3. Ma Y, Seiler KP, Eichwals EJ, Weis JH, Teuscher C, Weiss JJ, 1998. Distinct characteristics of resistance to Borrelia burgdorferi-induced arthritis in C57BL/6N mice. Infect Immun 66 : 161–168. [Google Scholar]
  4. Weis JJ, 2002. Host-pathogen interactions and the pathogenesis of murine Lyme disease. Curr Opin Rheumatol 14 : 399–403. [Google Scholar]
  5. Radolf JD, Arndt LL, Akins DR, Curetty LL, Levi ME, Shen Y, Davis LS, Norgard MV, 1995. Treponema pallidum and Borrelia burgdorferi lipoproteins and synthetic lipopeptides activate monocytes/macrophages. J Immunol 154 : 2866–2877. [Google Scholar]
  6. Wooten RM, Ma Y, Yoder RA, Brown JP, Weis JH, Zachary JF, Kirschning CJ, Weis JJ, 2002. Toll-like receptor 2 is required for innate, but not acquired, host defense to Borrelia burgdorferi. J Immunol 168 : 348–355. [Google Scholar]
  7. Talkington J, Nickell SP, 2001. Role of Fc gamma receptors in triggering host cell activation and cytokine release by Borrelia burgdorferi. Infect Immun 69 : 413–419. [Google Scholar]
  8. Defosse DL, Johnson RC, 1992. In vitro and in vivo induction of tumor necrosis factor alpha by Borrelia burgdorferi. Infect Immun 60 : 1109–1113. [Google Scholar]
  9. Biron CA, Gazzinelli RT, 1995. Effects of IL-12 on immune responses to microbial infections: a key mediator in regulating disease outcome. Curr Opin Immunol 7 : 485–496. [Google Scholar]
  10. Grusell M, Widhe M, Ekerfelt C, 2002. Increased expression of the Th1-inducing cytokines interleukin-12 and interleukin-18 in cerebrospinal fluid but not in sera from patients with Lyme neuroborreliosis. J Neuroimmunol 131 : 173–178. [Google Scholar]
  11. Craig-Mylius K, Weber GF, Coburn J, Glickstein L, 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response. J Leukoc Biol 77 : 710–718. [Google Scholar]
  12. Montgomery RR, Malawista SE, 1996. Entry of Borrelia burgdorferi into macrophages is end-on and leads to degradation in lysosomes. Infect Immun 64 : 2867–2872. [Google Scholar]
  13. Coburn J, Leong JM, Erban JK, 1993. Integrin αIIb β3 mediates binding of the Lyme disease agent Borrelia burgdorferi to human platelets. Proc Natl Acad Sci U S A 90 : 7059–7063. [Google Scholar]
  14. Coburn J, Chege W, Magoun L, Bodary SC, Leong JM, 1999. Characterization of a candidate Borrelia burgdorferi β3-chain integrin ligand identified using a phage display library. Mol Microbiol 34 : 926–940. [Google Scholar]
  15. Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A, 2002. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17 : 583–591. [Google Scholar]
  16. Ciaramella A, Cavone A, Santucci MB, Amicosante M, Martino A, Auricchio G, Pucillo LP, Colizzi V, Fraziano M, 2002. Proinflammatory cytokines in the course of Mycobacterium tuberculosis-induced apoptosis in monocytes/macrophages. J Infect Dis 186 : 1277–1282. [Google Scholar]
  17. Glickstein LJ, Huber BT, 1995. Karoushi – death by overwork in the immune system. J Immunol 155 : 522–524. [Google Scholar]
  18. Zeidner N, Mbow ML, Dolan M, Massung R, Baca E, Piesman J, 1997. Effects of Ixodes scapularis and Borrelia burgdorferi on modulation of the host immune response: induction of a TH2 cytokine response in Lyme disease-susceptible (C3H/HeJ) mice but not in disease-resistant (BALB/c) mice. Infect Immun 65 : 3100–3106. [Google Scholar]
  19. Zeidner N, Dreitz M, Belasco D, Fish D, 1996. Suppression of acute Ixodes scapularis-induced Borrelia burgdorferi infection using tumor necrosis factor-alpha, interleukin-2, and interferon- gamma. J Infect Dis 173 : 187–195. [Google Scholar]
  20. Barthold SW, Sidman CL, Smith AL, 1992. Lyme borreliosis in genetically resistant and susceptible mice with severe combined immunodeficiency. Am J Trop Med Hyg 47 : 605–613. [Google Scholar]
  21. Schaible UE, Kramer MD, Wallich R, Tran T, Simon MM, 1991. Experimental Borrelia burgdorferi infection in inbred mouse strains: antibody response and association of H-2 genes with resistance and susceptibility to development of arthritis. Eur J Immunol 21 : 2397–2405. [Google Scholar]
  22. Weis JJ, McCracken BA, Ma Y, Fairbairn D, Rober RJ, Morrison TB, Weis JH, Zachary JF, Dorge RW, Teuscher C, 1999. Identification of quantitative trait loci governing arthritis severity and humoral responses in the murine model of Lyme disease. J Immunol 162 : 948–956. [Google Scholar]
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2006.75.964
Loading
ASSOCIATION OF MACROPHAGE INFLAMMATORY RESPONSE AND CELL DEATH AFTER IN VITRO BORRELIA BURGDORFERI INFECTION WITH ARTHRITIS RESISTANCE
The American Journal of Tropical Medicine and Hygiene 75, 964 (2006); https://doi.org/10.4269/ajtmh.2006.75.964
/content/journals/10.4269/ajtmh.2006.75.964
/content/journals/10.4269/ajtmh.2006.75.964
Loading

Data & Media loading...

  • Received : 03 May 2006
  • Accepted : 23 Jun 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error