1921
Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

In this study, CD4 and CD8 T cells and antibody levels were measured in 94 migrant fishermen infected with from Dongting Lake, China. Prevalence among these fishermen was high (63.8%), with a mean infection intensity of 61.4 ± 3.8 epg, and included a high proportion of individuals (39.4%) with substantial parenchymal fibrosis (stages ≥ 2/3). The CD4/CD8 ratio in men (1.34 ± 0.11) was significantly lower than that of women (1.58 ± 0.15). CD4 T cells and the ratio of CD4/CD8 were significantly decreased both in subjects infected with and those with parenchymal fibrosis. However, levels of total IgA, IgM, and anti-schistosome egg antigen IgG correlated positively with infection intensity and pathologic lesion number. These results suggest an imbalance between cell-mediated and humoral immunity in these fishermen, the precise cause of which remains undetermined.

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2006-11-01
2017-09-25
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  • Received : 31 Jan 2006
  • Accepted : 23 Jun 2006

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