Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Most infections are egg-negative after a single dose of oxamniquine. A cohort of 661 infected children was treated at 6-month intervals and assessed for nutritional and parasitological status. Initial biochemical and immunologic markers were measured in a subset of 84 children. All were treated at the start of therapy and at 6 months. Immunoglobulins only served as markers for active infection. No markers were predictive of cure or reinfection, except initial infection intensity and serum low-density lipoprotein. Ten percent were persistently infected and had no change in infection intensity at any time-point. Several factors suggest that this group was biologically different. In addition to failing to reduce their worm burden, they had significantly higher initial intensity of infection (100 versus 65 eggs/g, = 0.001) and significantly lower initial serum low-density lipoprotein (72 versus 104 mg/dL, = 0.045). The biologic plausibility of this observation is discussed.


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  • Received : 10 Aug 2005
  • Accepted : 12 Apr 2006

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