1921
Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Glutathione S-transferases (GST) are a family of enzymes involved in phase-II detoxification of endogenous and xenobiotic compounds. Polymorphisms in GST genes have been associated with susceptibility to different diseases. In this study we determined the frequencies of polymorphisms in , , and in DNA of 138 children from Cameroon, presenting with uncomplicated malaria ( = 19), malaria with minor complications ( = 81), or severe malaria ( = 38). Analyses of and were performed using PCR-multiplex procedure, while was done by PCR-RFLP. Subjects presenting with malaria with complications were found more often of the -null genotype (58–64%) as compared with those with uncomplicated malaria (32%), a difference that was statistically significant. We conclude that the -null genotype is associated with malaria with complications.

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2006-11-01
2017-11-18
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  • Received : 21 Mar 2006
  • Accepted : 05 Jul 2006

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