1921
Volume 75, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Acute exposure to 2,3,7,8-tetrachlorodibenzo--dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of –infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to in the face of immune suppression.

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  • Received : 04 Oct 2005
  • Accepted : 24 May 2006

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