1921
Volume 75, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Schistosomiasis is associated with undernutrition, but the mechanisms involved remain unknown. We analyzed baseline and follow-up data from a longitudinal treatment–reinfection study in = 477 –infected subjects 7–20 years of age from Leyte, the Philippines. After baseline treatment with praziquantel, follow-up visits were scheduled every 3 months for 18 months; stool, venous blood, and anthropometric measurements were collected at each visit. Cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with specific antigens was measured once 4 weeks after treatment. After adjustment for confounders, intensity was associated with decreased serum albumin and Z-scores (all < 0.05) and with increased serum C-reactive protein (CRP) and interleukin (IL)-6. CRP was associated with decreased albumin and Z-scores (all < 0.01). Production of IL-1b and tumor necrosis factor (TNF)-α in response to worm antigen was associated with decreased albumin (both < 0.005) and height-for-age Z-score (TNF-α only, = 0.05). –associated undernutrition may, in part, result directly from inflammation.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2006.75.720
2006-10-01
2017-09-19
Loading full text...

Full text loading...

/deliver/fulltext/14761645/75/4/0750720.html?itemId=/content/journals/10.4269/ajtmh.2006.75.720&mimeType=html&fmt=ahah

References

  1. Hunter GW, 2000. Hunter’s Tropical Medicine and Emerging Infectious Diseases. Philadelphia, PA: W.B. Saunders Company.
  2. Murray C, Lopez A, 1996. Global Health Statistics: A Compendium of Incidence, Prevalence and Mortality Estimates for Over 200 Conditions. Boston, MA: Harvard University Press.
  3. McGarvey ST, Aligui G, Daniel BL, Peters P, Olveda R, Olds GR, 1992. Child growth and schistosomiasis japonica in northeastern Leyte, the Philippines: cross-sectional results. Am J Trop Med Hyg 46 : 571–581.
  4. McGarvey ST, Aligui G, Graham KK, Peters P, Olds GR, Olveda R, 1996. Schistosomiasis japonica and childhood nutritional status in northeastern Leyte, the Philippines: A randomized trial of praziquantel versus placebo. Am J Trop Med Hyg 54 : 498–502.
  5. McGarvey ST, Wu G, Zhang S, Wang Y, Peters P, Olds GR, Wiest PM, 1993. Child growth, nutritional status, and schistosomiasis japonica in Jiangxi, People’s Republic of China. Am J Trop Med Hyg 48 : 547–553.
  6. Kotler DP, 2000. Cachexia. Ann Intern Med 133 : 622–634.
  7. Oldenburg HS, Rogy MA, Lazarus DD, Van Zee KJ, Keeler BP, Chizzonite RA, Lowry SF, Moldawer LL, 1993. Cachexia and the acute-phase protein response in inflammation are regulated by interleukin-6. Eur J Immunol 23 : 1889–1894.
  8. Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD, 2004. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr 80 : 299–307.
  9. Mahmoud FA, Rivera NI, 2002. The role of C-reactive protein as a prognostic indicator in advanced cancer. Curr Oncol Rep 4 : 250–255.
  10. Mwatha JK, Kimani G, Kamau T, Mbugua GG, Ouma JH, Mumo J, Fulford AJ, Jones FM, Butterworth AE, Roberts MB, Dunne DW, 1998. High levels of TNF, soluble TNF receptors, soluble ICAM-1, and IFN-gamma, but low levels of IL-5, are associated with hepatosplenic disease in human schistosomiasis mansoni. J Immunol 160 : 1992–1999.
  11. Khalil RM, Hultner L, Mailhammer R, Luz A, Moeller J, Mohamed AA, Omran S, Dormer P, 1996. Kinetics of interleukin-6 production after experimental infection of mice with Schistosoma mansoni. Immunology 89 : 256–261.
  12. Marguerite M, Gallissot MC, Diagne M, Moreau C, Diakkhate MM, Roberts M, Remoue F, Thiam A, Decam C, Rogerie F, Cottrez F, Neyrinck JL, Butterworth AE, Sturrock RF, Piau JP, Daff B, Niang M, Wolowczuk I, Riveau G, Auriault C, Capron A, 1999. Cellular immune responses of a Senegalese community recently exposed to Schistosoma mansoni: Correlations of infection level with age and inflammatory cytokine production by soluble egg antigen-specific cells. Trop Med Int Health 4 : 530–543.
  13. Abdel Azim A, Sedky HA, el-Tahawy MA, Fikry AA, Mostafa H, 1995. Serum levels of tumor necrosis factor in different stages of schistosomal infection. J Egypt Soc Parasitol 25 : 279–287.
  14. de Jesus AR, Silva A, Santana LB, Magalhaes A, de Jesus AA, de Almeida RP, Rego MA, Burattini MN, Pearce EJ, Carvalho EM, 2002. Clinical and immunologic evaluation of 31 patients with acute schistosomiasis mansoni. J Infect Dis 185 : 98–105.
  15. Haseeb MA, Shirazian DJ, Preis J, 2001. Elevated serum levels of TNF-alpha, sTNF-RI and sTNF-RII in murine schistosomiasis correlate with schistosome oviposition and circumoval granuloma formation. Cytokine 15 : 266–269.
  16. Twisk J, de Vente W, 2002. Attrition in longitudinal studies. How to deal with missing data. J Clin Epidemiol 55 : 329–337.
  17. WHO, 1987. Prevention and Control of Intestinal Parasitic Infections. WHO Tech Rep Ser 749 : 8–28.
  18. Gibson R, 1990. Principles of Nutritional Assessment. New York: Oxford University Press.
  19. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, Grummer-Strawn LM, Curtin LR, Roche AF, Johnson CL, 2002. Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 109 : 45–60.
  20. Coutinho HM, Acosta LP, McGarvey ST, Jarilla B, Jiz M, Pablo A, Su L, Manalo DL, Olveda RM, Kurtis JD, Friedman JF, 2006. Nutritional status improves after treatment of Schistosoma japonicum-infected children and adolescents. J Nutr 136 : 183–188.
  21. Frisancho AR, 1990. Anthropometric Standards for the Assessment of Growth and Nutritional Status. Ann Arbor, Michigan: University of Michigan Press.
  22. Leenstra T, Acosta LP, Langdon GC, Manalo DL, Su L, Olveda RM, McGarvey ST, Kurtis JD, Friedman JF, 2006. Schistosomiasis japonica, anemia, and iron status in children, adolescents, and young adults in Leyte, Philippines 1. Am J Clin Nutr 83 : 371–379.
  23. Leenstra T, Acosta LP, Wu HW, Langdon GC, Solomon JS, Manalo DL, Su L, Jiz M, Jarilla B, Pablo AO, McGarvey ST, Olveda RM, Friedman JF, Kurtis JD, 2006. T-helper-2 cytokine responses to Sj97 predict resistance to reinfection with Schistosoma japonicum. Infect Immun 74 : 370–381.
  24. Boros DL, Warren KS, 1970. Delayed hypersensitivity-type granuloma formation and dermal reaction induced and elicited by a soluble factor isolated from Schistosoma mansoni eggs. J Exp Med 132 : 488–507.
  25. Acosta LP, Waine G, Aligui GD, Tiu WU, Olveda RM, McManus DP, 2002. Immune correlate study on human Schistosoma japonicum in a well-defined population in Leyte, Philippines: II. Cellular immune responses to S. japonicum recombinant and native antigens. Acta Trop 84 : 137–149.
  26. Coutinho HM, McGarvey ST, Acosta LP, Manalo DL, Langdon GC, Leenstra T, Kanzaria HK, Solomon J, Wu H, Olveda RM, Kurtis JD, Friedman JF, 2005. Nutritional status and serum cytokine profiles in children, adolescents, and young adults with Schistosoma japonicum-associated hepatic fibrosis, in Leyte, Philippines. J Infect Dis 192 : 528–536.
  27. Dati F, Schumann G, Thomas L, Aguzzi F, Baudner S, Bienvenu J, Blaabjerg O, Blirup-Jensen S, Carlstrom A, Petersen PH, Johnson AM, Milford-Ward A, Ritchie RF, Svendsen PJ, Whicher J, 1996. Consensus of a group of professional societies and diagnostic companies on guidelines for interim reference ranges for 14 proteins in serum based on the standardization against the IFCC/BCR/CAP Reference Material (CRM 470). International Federation of Clinical Chemistry. Community Bureau of Reference of the Commission of the European Communities. College of American Pathologists. Eur J Clin Chem Clin Biochem 34 : 517–520.
  28. Fitzmaurice G, 2004. Applied Longitudinal Analysis. Hoboken, NJ: John Wiley & Sons.
  29. Margarson MP, Soni N, 1998. Serum albumin: Touchstone or totem? Anaesthesia 53 : 789–803.
  30. King CH, Dickman K, Tisch DJ, 2005. Reassessment of the cost of chronic helmintic infection: A meta-analysis of disability-related outcomes in endemic schistosomiasis. Lancet 365 : 1561–1569.
  31. Plata-Salaman CR, 2000. Central nervous system mechanisms contributing to the cachexia-anorexia syndrome. Nutrition 16 : 1009–1012.
  32. Qureshi AR, Alvestrand A, Danielsson A, Divino-Filho JC, Gutierrez A, Lindholm B, Bergstrom J, 1998. Factors predicting malnutrition in hemodialysis patients: A cross-sectional study. Kidney Int 53 : 773–782.
  33. Kaizu Y, Ohkawa S, Odamaki M, Ikegaya N, Hibi I, Miyaji K, Kumagai H, 2003. Association between inflammatory mediators and muscle mass in long-term hemodialysis patients. Am J Kidney Dis 42 : 295–302.
  34. Zern MA, Saber MA, Shafritz DA, 1983. Molecular mechanisms for changes in hepatic protein synthesis induced by schistosomiasis infection in mice. Biochemistry 22 : 6072–6077.
  35. Don BR, Kaysen G, 2004. Serum albumin: Relationship to inflammation and nutrition. Semin Dial 17 : 432–437.
  36. Curwen RS, Ashton PD, Johnston DA, Wilson RA, 2004. The Schistosoma mansoni soluble proteome: A comparison across four life-cycle stages. Mol Biochem Parasitol 138 : 57–66.
  37. Hagel I, Lynch NR, Di Prisco MC, Sanchez J, Perez M, 1995. Nutritional status and the IgE response against Ascaris lumbricoides in children from a tropical slum. Trans R Soc Trop Med Hyg 89 : 562–565.
  38. Suskind RM, Tontisirin K, 2001. Nutrition, Immunity, and Infection in Infants and Children. Philadelphia, PA: Lippincott Williams & Wilkins.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2006.75.720
Loading
/content/journals/10.4269/ajtmh.2006.75.720
Loading

Data & Media loading...

  • Received : 21 Apr 2006
  • Accepted : 18 May 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error