Volume 75, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Schistosomiasis is associated with undernutrition, but the mechanisms involved remain unknown. We analyzed baseline and follow-up data from a longitudinal treatment–reinfection study in = 477 –infected subjects 7–20 years of age from Leyte, the Philippines. After baseline treatment with praziquantel, follow-up visits were scheduled every 3 months for 18 months; stool, venous blood, and anthropometric measurements were collected at each visit. Cytokine production by peripheral blood mononuclear cells (PBMCs) stimulated with specific antigens was measured once 4 weeks after treatment. After adjustment for confounders, intensity was associated with decreased serum albumin and Z-scores (all < 0.05) and with increased serum C-reactive protein (CRP) and interleukin (IL)-6. CRP was associated with decreased albumin and Z-scores (all < 0.01). Production of IL-1b and tumor necrosis factor (TNF)-α in response to worm antigen was associated with decreased albumin (both < 0.005) and height-for-age Z-score (TNF-α only, = 0.05). –associated undernutrition may, in part, result directly from inflammation.


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  • Received : 21 Apr 2006
  • Accepted : 18 May 2006

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