Volume 75, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Artemisinins show the potential for neurotoxicity in preclinical studies. Artemisone is a leading candidate of second-generation semi-synthetic artemisinin derivatives for antimalarial therapy devoid of neurotoxicity. Artemisone showed 3–5-fold higher activity (50% effective concentration (EC) = 0.14 nmol/L, EC = 2.55 nmol/L) than artesunate against fresh isolates from Gabon and a high-activity correlation indicates a shared drug target.


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  • Received : 18 Apr 2006
  • Accepted : 06 Jun 2006

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