1921
Volume 75, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The increasing use of sulfadoxine-pyrimethamine (SP) for the treatment of chloroquine-resistant has resulted in increased reports of SP resistance of worldwide. Selection of SP-resistant in areas where and co-exist is not entirely clear. We examined the prevalence and extent of point mutations in and in 70 isolates from China, East Timor, Papua New Guinea (PNG), Philippines, Vanuatu, and Vietnam. Mutations in seven codon positions were found in , with the majority of isolates having double mutations (S58R/S117N). The greatest range of mutations was observed in the PNG and Vanuatu isolates, ranging from single to quadruple mutations (F57L/S58R/T61M/S117T). Single mutations in were observed only in parasites with mutations in corresponding . Parasites with the S58R/S117N allelic type showed an MIC level for pyrimethamine and cycloguanil comparable to that previously reported, but were susceptible to WR99210.

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2006-10-01
2017-09-23
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  • Received : 23 Feb 2006
  • Accepted : 12 Jun 2006

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