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Volume 75, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

The effects of albendazole and Yin-Chen-Extract co-therapy on -induced eosinophilic meningitis in BALB/c mice were evaluated. Assay indicators for the therapeutic effect include worm recovery, histopathological score of the fourth ventricle, tissue-type plasminogen activator, urokinasetype plasminogen activator, matrix metalloproteinase-9, cerebrospinal fluid total protein, leukocyte counts, and proinflammatory cytokines. As a result, albendazole and Yin-Chen-Extract co-therapy significantly decreased ( < 0.05) these factors. Although Yin-Chen-Extract may possess pharmacologic activities beneficial to the inhibition of parasite-induced inflammation, many of these hypothetical benefits await scientific testing and confirmation before application. This study suggests that the combination of Yin-Chen-Extract and albendazole has synergistic effects in managing eosinophilic meningitis or eosinophilic meningoencephalitis.

Copyright 2006 The American Society of Tropical Medicine
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2006-09-01
2018-11-14

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References

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CHINESE HERBAL MEDICINE YIN-CHEN-EXTRACT AS AN ADJUNCT TO ANTHELMINTIC ALBENDAZOLE USED AGAINST ANGIOSTRONGYLUS CANTONENSIS-INDUCED EOSINOPHILIC MENINGITIS OR MENINGOENCEPHALITIS
The American Journal of Tropical Medicine and Hygiene 75, 556 (2006); https://doi.org/10.4269/ajtmh.2006.75.556
/content/journals/10.4269/ajtmh.2006.75.556
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  • Received : 04 Jan 2006
  • Accepted : 20 Apr 2006

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