Volume 75, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


To describe the clinical features of dengue cases in Japan, a retrospective study was conducted on 62 laboratory-confirmed Japanese dengue cases presented to Tokyo Metropolitan Komagome Hospital between 1985 and 2000. Age distribution was from 18 to 62 years old (mean, 31.5 years). All cases were imported from abroad and diagnosed as dengue fever. Clinical manifestations included fever (100%), headache (90%), and skin rash (82%). Laboratory examinations revealed leukocytopenia (71%), thrombocytopenia (57%), elevated levels of serum aspartate aminotransferase (78%), and lactate dehydrogenase (71%). Antibody responses were consistent with that of secondary flavivirus infection in 60% of cases. Severity of symptoms in patients with primary dengue antibody response and those with secondary flavivirus antibody responses didn’t show statistical significance. Dengue virus infection should be taken into consideration in the differential diagnosis of febrile patients who recently entered Japan from tropical or subtropical countries.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. World Health Organization, 1997. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization.
  2. Hotta S, 2000. Dengue fever and dengue virus—a challenge to tropical medicine. Jpn J Trop Med Hyg 28 : 369–381.
    [Google Scholar]
  3. Yamada KI, Takasaki T, Nawa M, Nakayama M, Arai YT, Yabe S, Kurane I, 1999. The features of imported dengue fever cases from 1996 to 1999. Jpn J Infect Dis 52 : 257–259.
    [Google Scholar]
  4. Kurane I, Takasaki T, Yamada K, 2000. Trends in flavivirus infections in Japan. Emerg Infect Dis 6 : 569–571.
    [Google Scholar]
  5. Judicial System Department, Ministers Secretariat, 2001. Ministry of Justice. Annual Report of Statistics on Legal Migrants. Tokyo, Ministry of Justice.
  6. Konishi E, Suzuki T, 2002. Ratios of subclinical to clinical Japanese encephalitis (JE) virus infections in vaccinated populations: evaluation of an inactivated JE vaccine by comparing the ratios with those in unvaccinated populations. Vaccine 21 : 98–107.
    [Google Scholar]
  7. Hoke CH, Nisalak A, Sangawhipa N, Jatanasen S, Laorakapongse T, Innis BL, Kotchasenee S, Gingrich JB, Latendresse J, Fukai K, Burke DS, 1988. Protection against Japanese encephalitis by inactivated vaccines. N Engl J Med 319 : 608–614.
    [Google Scholar]
  8. Yamada K, Nawa M, Takasaki T, Yabe S, Kurane I, 1999. Laboratory diagnosis of dengue virus infection by reverse transcriptase polymerase chain reaction (RT-PCR) and IgM-capture enzyme-linked immunosorbent assay (ELISA). Jpn J Infect Dis 52 : 150–155.
    [Google Scholar]
  9. Yamada K, Takasaki T, Nawa M, Yabe S, Kurane I, 2003. Antibody responses determined for Japanese dengue fever patients by neutralization and hemagglutination inhibition assays demonstrate cross-reactivity between dengue and Japanese encephalitis viruses. Clin Diagn Lab Immunol 10 : 725–728.
    [Google Scholar]
  10. Clarke T, 2002. Dengue virus: Break-bone fever. Nature 416 : 672–674.
    [Google Scholar]
  11. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachueke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176 : 313–321.
    [Google Scholar]
  12. Schwartz E, Mendelson E, Sidi Y, 1996. Dengue fever among travelers. Am J Med 101 : 516–520.
    [Google Scholar]
  13. Guard RW, Stallman ND, Wiemers MA, 1984. Dengue in the northern region of Queensland, 1981–1982. Med J Aust 140 : 765–769.
    [Google Scholar]
  14. Infectious Diseases Control Division, Ministry of Health and Welfare, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, 1996. Annual Report 1996. National Epidemiological Surveillance of Vaccine-Preventable Diseases. Tokyo, Ministry of Health and Welfare.
  15. Peragallo MS, Nicoletti L, Lista F, D’Amelio R, East Timor Dengue Study Group, 2003. Probable dengue virus infection among Italian troops, East Timor, 1999–2000. Emerg Infect Dis 9 : 876–880.
    [Google Scholar]

Data & Media loading...

  • Received : 04 Nov 2005
  • Accepted : 16 May 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error