Volume 75, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


In this prospective study, we assessed the simplified multi-organ dysfunction score (sMODS) in 485 consecutive African children, hospitalized with malaria. Children were grouped according to their ability to walk unaided (Group 1, = 414), sit unaided (Group 2, = 63), or inability of both (Group 3, = 8) before contracting malaria. The sMODS on admission to hospital was highly correlated with prolonged disease duration in Groups 1 and 2 (Spearman = 0.79 and = 0.78, respectively). A sMODS of ≥ 16 was indicative for prolonged disease duration in Group 1 (> 48 hours of inability to walk, sensitivity of 87%, specificity of 82%) and Group 2 (> 24 hours of inability to sit, sensitivity of 100%, and specificity of 78%.). The simplified MODS is a simple and sensitive measure merit of severity of illness in children with malaria and allows early prognostic evaluation.


Article metrics loading...

Loading full text...

Full text loading...



  1. Kremsner PG, Krishna S, 2004. Antimalarial combinations. Lancet 264 : 285–294.
  2. Teasdale G, Jennett B, 1974. Assessment of coma and impaired consciousness. A practical scale. Lancet 2 : 81–84.
  3. Molyneux ME, Taylor TE, Wirima JJ, Borgstein A, 1989. Clinical features and prognostic indicators in peadiatric cerebral malaria: A study of 131 comatose Malawian children. Q J Med 71 : 441.
  4. World Health Organization, 2000. Severe falciparum malaria. Trans R Soc Trop Med Hyg 94 : S1–S90.
  5. Helbok R, Dent W, Nacher M, Treeprasertsuk S, Krudsood S, Wilairatana P, Silachamroon U, Looareesuwan S, Schmutzhard E, 2003. Use of the Multi-Organ Dysfunction Score as a tool to discriminate different levels of severity in uncomplicated Plasmodium falciparum malaria. Am J Trop Med Hyg 68 : 372–375.
  6. Helbok R, Dent W, Nacher M, Lackner P, Treeprasertsuk S, Krudsood S, Wilairatana P, Silachamroon U, Looareesuwan S, Schmutzhard E, 2005. The Use of the Multi-Organ Dysfunction Score to discriminate different levels of severity in severe and complicated Plasmodium falciparum malaria. Am J Trop Med Hyg 72 : 150–154.
  7. Behrman RE, Kliegman RM, Jenson HB, 2002. Nelson Textbook of Pediatrics. Seventeenth edition. Philadelphia, PA: Saunders.
  8. Weiler T, Baldering HJ, Heinrichs W, Schmitz JE, 1997. Qualitätssicherung in der Intensivmedizin. Ergebnisse einer Multi-centerstudie in Deutschland. Anästhesiol Intensivmed Schmerzther 32 : 372–375.
  9. Sylla EH, Kun JFJ, Kremsner PG, 2000. Mosquito distribution and entomological inoculation rates in three malaria-endemic areas in Gabon. Trans R Soc Trop Med Hyg 94 : 652–656.
  10. Wildling E, Winkler S, Kremsner PG, Brandts C, Jenne L, Wernsdorfer WH, 1995. Malaria epidemiology in the province of Moyen Ogoov, Gabon. Trop Med Parasitol 46 : 77–82.
  11. Jennett B, Bond M, 1975. Assessment of outcome after severe brain damage. Lancet 1 : 480–484.
  12. Lopansri BK, Anstey NM, Weinberg JB, Stoddard GJ, Hobbs MR, Levesque MC, Mwaikambo ED, Granger DL, 2003. Low plasma arginine concentrations in children with cerebral malaria and decreased nitric oxide production. Lancet 361 : 676–678.
  13. Schmutzhard E, Gerstenbrand F, 1984. Cerebral malaria in Tanzania. ITS epidemiology, clinical symptoms and neurological long term sequelae in the light of 66 cases. Tran R Soc Trop Med Hyg 78 : 351–353.
  14. Carter JA, Murira GM, Ross AJ, Munǵdala-Odera V, Newton CR, 2003. Speech and language sequelae of severe malaria in Kenyan children. Brain Inj 17 : 217–224.
  15. Carter JA, Ross AJ, Neville BG, Obiero E, Katana K, Munǵdala-Odera V, Lees JA, Newton CR, 2005. Developmental impairments following severe falciparum malaria in children. Trop Med Int Health 10 : 3–10.

Data & Media loading...

  • Received : 09 Dec 2005
  • Accepted : 01 Apr 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error