Volume 75, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A controlled randomized trial of antihelminthic treatment was undertaken in 1996–1997 in a rural area of Madagascar where populations were simultaneously infected with and . Levamisole was administered bimonthly to 164 subjects, randomized on a family basis, whereas 186 were controls. While levamisole proved to be highly effective in reducing egg loads in the treated group ( < 10 at all bimonthly visits), subjects more than 5 years of age, treated with levamisole had a significant increase in their densities compared with controls ( = 0.02), whereas there was no effect of anti-helminthic treatment on children 6 months to 4 years of age. The demonstration of a clear negative interaction between infection and malaria parasite density has important implications. Single community therapy programs to deliver treatments against several parasitic infections could avoid an increase of malaria attacks after mass treatment of ascariasis.


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  • Received : 26 Aug 2005
  • Accepted : 21 Dec 2005

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