Volume 75, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Although it is well known that SR-A I/II plays a significant role in host defense against bacterial and viral infection, the contribution of SR-A I/II to protozoan infection is not well understood. Thus, we examined the possible role of SR-A I/II against murine malarial infection, such as and by using SR-A I/II knockout mice with a C57BL/6J genetic background. When SR-A I/II knockout mice were infected with NK65 or 17X, their survival rates were not significantly different from wild-type animals. In terms of the kinetics of parasitemia, hematocrit values and the number of white blood cells, there were no significant differences between the genotypes in NK65 or 17X infection. Taken together with the findings in our previous report, the SR-A I/II functional contribution to host defense in malarial infection does not seem to be widely extended, and the effect of SR-A I/II seem in collaboration with other, as yet unidentified, gene(s).


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  1. Kodama T, Reddy P, Kishimoto C, Krieger M, 1988. Purification and characterization of a bovine acetyl low density lipoprotein receptor. Proc Natl Acad Sci U S A 85 : 9238–9242.
  2. Kodama T, Freeman M, Rohrer L, Zabrecky J, Matsudaira P, Krieger M, 1990. Type I macrophage scavenger receptor contains alpha-helical and collagen-like coiled coils. Nature 343 : 531–535.
  3. Rohrer L, Freeman M, Kodama T, Penman M, Krieger M, 1990. Coiled-coil fibrous domains mediate ligand binding by macrophage scavenger receptor type II. Nature 343 : 570–572.
  4. Steinbrecher UP, 1999. Receptors for oxidized low density lipoprotein. Biochim Biophys Acta 1436 : 279–298.
  5. Fraser I, Hughes D, Gordon S, 1993. Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor. Nature 364 : 343–346.
  6. Suzuki H, Kurihara Y, Takeya M, Kamada N, Kataoka M, Jishage K, Ueda O, Sakaguchi H, Higashi T, Suzuki T, Takashima Y, Kawabe Y, Cynshi O, Wada Y, Honda M, Kurihara H, Aburatani H, Doi T, Matsumoto A, Azuma S, Noda T, Toyoda Y, Itakura H, Yazaki Y, Horiuchi S, Takahashi K, Kruijt JK, van Berkel TJC, Steinbrecher UP, Ishibashi S, Maeda N, Gordon S, Kodama T, 1997. A role for macrophage scavenger receptor in atherosclerosis and susceptibility to infection. Nature 386 : 292–296.
  7. Hampton RY, Golenbock DT, Penman M, Krieger M, Raetz CR, 1991. Recognition and plasma clearance of endotoxin by scavenger receptors. Nature 352 : 342–344.
  8. Dunne DW, Resnick D, Greenberg J, Krieger M, Joiner KA, 1994. The type macrophage scavenger receptor binds to gram-positive bacteria and recognizes lipoteichoic acid. Proc Natl Acad Sci U S A 91 : 1863–1867.
  9. Thomas CA, Li Y, Kodama T, Suzuki H, Silverstein SC, El Khoury J, 2000. Protection from lethal gram-positive infection by macrophage scavenger receptor-dependent phagocytosis. J Exp Med 191 : 147–156.
  10. Hagiwara S, Takeya M, Suzuki H, Kodama T, van der Laan LJW, Kraal G, Kitamura N, Takahashi K, 1999. Role of macrophage scavenger receptors in hepatic granuloma formation in mice. Am J Pathol 154 : 705–720.
  11. Haworth R, Platt N, Keshav S, Hughes D, Darley E, Suzuki H, Kurihara Y, Kodama T, Gordon S, 1997. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock. J Exp Med 186 : 1431–1439.
  12. Nogami S, Watanabe J, Nakagaki K, Nakata K, Suzuki H, Suzuki H, Fujisawa M, Kodama T, Kojima S, 1998. Involvement of macrophage scavenger receptors in protection against murine malaria. Am J Trop Med Hyg 59 : 843–845.
  13. Kamada N, Kodama T, Suzuki H, 2001. Macrophage scavenger receptor (SR-A I/II) deficiency reduced diet-induced atherosclerosis in C57BL/6J mice. J Athroscler Thromb 8 : 1–6.
  14. Chou Q, Russell M, Birch DE, Raymond J, Bloch W, 1992. Prevention of pre-PCR mis-priming and primer dimerization improves low-copy-number amplifications. Nucleic Acids Res 20 : 1717–1723.
  15. Don RH, Cox PT, Wainwright BJ, Baker K, Mattick JS, 1991. “Touchdown” PCR to circumvent spurious priming during gene amplification. Nucleic Acids Res 19 : 4008.
  16. Hecker KH, Roux KH, 1996. High and low annealing temperatures increase both specificity and yield in touchdown and stepdown PCR. BioTechniques 20 : 478–485.
  17. Mackey LJ, Hochmann A, June CH, Contreras CE, Lambert PH, 1980. Immunopathological aspects of Plasmodium berghei infection in five strains of mice. Clin Exp Immunol 42 : 412–420.
  18. Jaffe RI, Lowell GH, Gordon DM, 1990. Differences in susceptibility among mouse strains to infection with Plasmodium berghei (ANKA clone) sporozoites and its relationship to protection by gamma-irradiated sporozoites. Am J Trop Med Hyg 42 : 309–313.
  19. Ohno T, Ishih A, Kohara Y, Yonekawa H, Terada M, Nishimura M, 2001. Chromosomal mapping of the host resistance locus to rodent malaria (Plasmodium yoelii) infection in mice. Immunogenetics 53 : 736–740.
  20. Hioki A, Yoshino M, Kano S, Ohtomo H, 1987. Pathophysiology of hypoxia in mice infected with Plasmodium berghei. Parasitol Res 73 : 298–302.
  21. Yoshimoto T, Takahama Y, Wang CR, Yoneto T, Waki S, Nariuchi H, 1998. A pathogenic role of IL-12 in blood-stage murine malaria lethal strain Plasmodium berghei NK65 infection. J Immunol 160 : 5500–5505.

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  • Received : 31 Aug 2005
  • Accepted : 12 Feb 2006

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