1921
Volume 75, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Although it is well known that SR-A I/II plays a significant role in host defense against bacterial and viral infection, the contribution of SR-A I/II to protozoan infection is not well understood. Thus, we examined the possible role of SR-A I/II against murine malarial infection, such as and by using SR-A I/II knockout mice with a C57BL/6J genetic background. When SR-A I/II knockout mice were infected with NK65 or 17X, their survival rates were not significantly different from wild-type animals. In terms of the kinetics of parasitemia, hematocrit values and the number of white blood cells, there were no significant differences between the genotypes in NK65 or 17X infection. Taken together with the findings in our previous report, the SR-A I/II functional contribution to host defense in malarial infection does not seem to be widely extended, and the effect of SR-A I/II seem in collaboration with other, as yet unidentified, gene(s).

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  • Received : 31 Aug 2005
  • Accepted : 12 Feb 2006

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