1921
Volume 75, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

One hundred thirty-eight adult patients with acute malaria were randomized to receive either β-arteether or α/β-arteether. The drugs were administered in the dose of 150 mg once a day intramuscularly for three consecutive days in hospitalized patients. After one week of hospitalization, patients were followed-up for three weeks after release from the hospital. There was no statistically significant difference between cure rates, mean fever clearance time (FCT), mean parasite clearance time (PCT), and occurrence of side effects in either group. The cure rate was 97.14% for β-arteether and 97.01 for α/β-arteether ( = 0.9660). The mean PCT was 38.49 hours for β-arteether and 36.90 hours for α/β-arteether ( = 0.6054), and the mean FCT was 37.27 hours for β-arteether and 37.9 hours for α/β-arteether ( = 0.8718). Both arteether formulations were safe and efficacious in reducing the clinical symptoms of acute falciparum malaria. There was also rapid clearance of parasitemia with both formulations. Thus, either β-arteether or α/β-arteether can be used in the treatment of acute falciparum malaria.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2006.75.139
2006-07-01
2017-11-20
Loading full text...

Full text loading...

/deliver/fulltext/14761645/75/1/0750139.html?itemId=/content/journals/10.4269/ajtmh.2006.75.139&mimeType=html&fmt=ahah

References

  1. Nosten F, Brasseur P, 2002. Combination therapy for malaria: the way forward? Drugs 62 : 1315–1329.
  2. Suh KN, Kain KC, Keystone JS, 2004. Malaria. CMAJ 170 : 1693–1702.
  3. World malaria situation in 1993. Part II, 1996. Wkly Epidemiol Rec 71 : 25–29.
  4. World malaria situation in 1994. Part III, 1997. Wkly Epidemiol Rec 72 : 285–290.
  5. Severe falciparum malaria. World Health Organization, Communicable Diseases Cluster, 2000. Trans R Soc Trop Med Hyg 94 : S1–S90.
  6. White NJ, 1996. The treatment of malaria. N Engl J Med 335 : 800–806.
  7. De Vries PJ, Dien TK, 1996. Clinical pharmacology and therapeutic potential of artemisinin and its derivatives in the treatment of malaria. Drugs 52 : 818–836.
  8. Valecha N, Gupta S, Usha D, Biswas S, Sharma A, Adak T, Asthana OP, Sharma VP, 1997. Efficacy of alpha,beta-arteether in acute uncomplicated P. falciparum malaria. Int J Clin Pharmacol Res. 17 : 11–15.
  9. Looareesuwan S, Oosterhuis B, Schilizzi BM, Sollie FA, Wilairatana P, Krudsood S, Lugt Ch B, Peeters PA, Peggins JO, 2002. Dose-finding and efficacy study for i.m. artemotil (beta-arteether) and comparison with i.m. artemether in acute uncomplicated P. falciparum malaria. Br J Clin Pharmacol 53 : 492–500.
  10. Asthana OP, Srivastava JS, Pandey TK, Vishwanathan KA, Dev V, Mahapatra KM, Nayak NC, Balsara AB, Mandal OP, Gupta N, Mishra SK, Mohanty S, Sathpathy S, Das BS, Patnaik JK, Sathpathy SK, Dash B, 2001. Multicentric clinical trials for safety and efficacy evaluation of alpha;beta arteether in complicated P. falciparum malaria. J Assoc Physicians India 49 : 1155–1160.
  11. Singh N, Shukla MM, Asthana OP, Sharma VP, 1998. Effectiveness of alpha-beta arteether in clearing Plasmodium falciparum parasitemia in central India (Madhya Pradesh). Southeast Asian J Trop Med Public Health 29 : 225–227.
  12. Moyou-Somo R, Tietche F, Ondoa M, Kouemeni LE, Ekoe T, Mbonda E, Nsangou C, Jemea B, Guemkam G, 2001. Clinical trial of beta-arteether versus quinine for the treatment of cerebral malaria in children in Yaounde, Cameroon. Am J Trop Med Hyg 64 : 229–232.
  13. Thuma PE, Bhat GJ, Mabeza GF, Osborne C, Biemba G, Shakankale GM, Peeters PA, Oosterhuis B, Lugt CB, Gordeuk VR, 2000. A randomized controlled trial of artemotil (beta-arteether) in Zambian children with cerebral malaria. Am J Trop Med Hyg 62 : 524–529.
  14. Tripathi R, Dutta GP, Vishwakarma RA, 1991. Comparison of antimalarial efficacy of alpha, beta, and alpha/beta arteether against Plasmodium cynomolgi B infection in monkeys. Am J Trop Med Hyg. 44 : 560–563.
  15. Kager PA, 2003. Three newly registered drugs in the Netherlands for the treatment and chemoprophylaxis of malaria: atova-quone-proguanil, artemether-lumefantrine and artemotil. Ned Tijdschr Geneeskd. 147 : 291–295.
  16. White NJ, 2003 Malaria. Cook GC, Zumla A, eds. Manson’s Tropical Diseases. 21st edition. Philadelphia: W. B. Saunders, 1205–1295.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2006.75.139
Loading
/content/journals/10.4269/ajtmh.2006.75.139
Loading

Data & Media loading...

  • Received : 16 Dec 2005
  • Accepted : 23 Feb 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error