1921
Volume 75, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

The diagnostic capacity of three malaria rapid diagnostic tests (RDTs), NOW-Malaria-ICT, OptiMAL-IT, and Paracheck-Pf, was evaluated against expert microscopy in Colombia. We tested 896 patients, of whom microscopy confirmed 139 , 279 , and 13 mixed infections and 465 negatives. Paracheck-Pf and NOW-malaria-ICT were more accurate in detecting (sensitivities 90.8% and 90.1%, respectively) in comparison with Optimal-IT (83.6%). NOW showed an acceptable detection rate at low densities (< 500/μL), but resulted in a higher proportion of false positives. For diagnosis, Optimal-IT had a higher sensitivity than NOW (91.0% and 81.4%, respectively). The choice between the two detecting RDTs balances and detection rates. Considering some degree of overtreatment and failure to detect all cases as more acceptable than missing some cases of , we recommend careful implementation of NOW-malaria-ICT in areas where microscopy is lacking. The price is however still a constraint.

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2006-12-01
2017-09-21
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  • Received : 08 Apr 2006
  • Accepted : 14 Aug 2006

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