1921
Volume 75, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Zoonotic infections caused by eating the meat of deer, wild boar, and pig have been suggested in Japan, a country that is not epidemic for hepatitis E caused by hepatitis E virus (HEV). This virus is widely spread in domestic pigs in both epidemic and non-epidemic countries. We studied fecal HEV shedding patterns on three Japanese farms that had two common genotype III HEV strains. Two of the three farms had high shedding peaks (75% and 100%) in pigs 1–3 months of age, suggesting that these animals had the highest risk of spreading HEV through feces. Another farm had a low shedding rate in animals six months of age and a low prevalence of the IgG antibody to HEV. Fecal IgA antibody to HEV was found in sucking pigs < 13 days of age on farms that had high and low shedding patterns. A small fraction of pigs (3 of 43 [7%]) at the finishing stage (5–6 months of age) still shed HEV on the three farms.

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2006-12-01
2017-09-20
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References

  1. Purcell RH, Emerson SU, 2001. Hepatitis E virus. Knipe DM, Howley PM, eds. Fields Virology. Philadelphia: Lippincott Williams and Wilkins, 3051–3061.
  2. Smith JL, 2001. A review of hepatitis E virus. J Food Prot 64 : 572–586.
  3. Li TC, Zhang J, Shinzawa H, Ishibashi M, Sata M, Mast EE, Kim K, Miyamura T, Takeda N, 2000. Empty virus-like particle-based enzyme-linked immunosorbent assay for antibodies to hepatitis E virus. J Med Virol 62 : 327–333.
  4. Mast EE, Kuramoto IK, Favorov MO, Schoening VR, Burkholder BT, Shapiro CN, Holland PV, 1997. Prevalence of and risk factors for antibody to hepatitis E virus seroreactivity among blood donors in northern California. J Infect Dis 176 : 34–40.
  5. Meng XJ, Dea S, Engle RE, Friendship R, Lyoo YS, Sirinarumitr T, Urairong K, Wang D, Wong D, Yoo D, Zhang Y, Purcell RH, Emerson SU, 1999. Prevalence of antibodies to the hepatitis E virus in pigs from countries where hepatitis E is common or is rare in the human population. J Med Virol 59 : 297–302.
  6. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, Emerson SU, Purcell RH, 2002. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J Clin Microbiol 40 : 117–122.
  7. Paul DA, Knigge MF, Ritter A, Gutierrez R, Pilot-Matias T, Chau KH, Dawson GJ, 1994. Determination of hepatitis E virus seroprevalence by using recombinant fusion proteins and synthetic peptides. J Infect Dis 169 : 801–806.
  8. Thomas DL, Yarbough PO, Vlahov D, Tsarev SA, Nelson KE, Saah AJ, Purcell RH, 1997. Seroreactivity to hepatitis E virus in areas where the disease is not endemic. J Clin Microbiol 35 : 1244–1247.
  9. Withers MR, Correa MT, Morrow M, Stebbins ME, Seriwatana J, Webster WD, Boak MB, Vaughn DW, 2002. Antibody levels to hepatitis E virus in North Carolina swine workers, non-swine workers, swine, and murids. Am J Trop Med Hyg 66 : 384–388.
  10. Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, Haynes JS, Thacker BJ, Emerson SU, 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc Natl Acad Sci U S A 94 : 9860–9865.
  11. Li TC, Chijiwa K, Sera N, Ishibashi T, Etoh Y, Shinohara Y, Kurata Y, Ishida M, Sakamoto S, Takeda N, Miyamura T, 2005. Hepatitis E virus transmission from wild boar meat. Emerg Infect Dis 11 : 1958–1960.
  12. Nishizawa T, Takahashi M, Endo K, Fujiwara S, Sakuma N, Kawazuma F, Sakamoto H, Sato Y, Bando M, Okamoto H, 2005. Analysis of the full-length genome of hepatitis E virus isolates obtained from wild boars in Japan. J Gen Virol 86 : 3321–3326.
  13. Sonoda H, Abe M, Sugimoto T, Sato Y, Bando M, Fukui E, Mizuo H, Takahashi M, Nishizawa T, Okamoto H, 2004. Prevalence of hepatitis E virus (HEV) infection in wild boars and deer and genetic identification of a genotype 3 HEV from a boar in Japan. J Clin Microbiol 42 : 5371–5374.
  14. Takahashi K, Kitajima N, Abe N, Mishiro S, 2004. Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer. Virology 330 : 501–505.
  15. Tei S, Kitajima N, Takahashi K, Mishiro S, 2003. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 362 : 371–373.
  16. Nakamura M, Takahashi K, Taira K, Taira M, Ohno A, Sakugawa H, Arai M, Mishiro S, 2006. Hepatitis E virus infection in wild mongooses of Okinawa, Japan: Demonstration of anti-HEV antibodies and a full-genome nucleotide sequence. Hepatol Res 34 : 137–140.
  17. Haqshenas G, Shivaprasad HL, Woolcock PR, Read DH, Meng XJ, 2001. Genetic identification and characterization of a novel virus related to human hepatitis E virus from chickens with hepatitis-splenomegaly syndrome in the United States. J Gen Virol 82 : 2449–2462.
  18. Payne CJ, Ellis TM, Plant SL, Gregory AR, Wilcox GE, 1999. Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus. Vet Microbiol 68 : 119–125.
  19. Nishizawa T, Takahashi M, Mizuo H, Miyajima H, Gotanda Y, Okamoto H, 2003. Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99% identity over the entire genome. J Gen Virol 84 : 1245–1251.
  20. Erker JC, Desai SM, Schlauder GG, Dawson GJ, Mushahwar IK, 1999. A hepatitis E virus variant from the United States: molecular characterization and transmission in cynomolgus macaques. J Gen Virol 80 : 681–690.
  21. Meng XJ, Halbur PG, Shapiro MS, Govindarajan S, Bruna JD, Mushahwar IK, Purcell RH, Emerson SU, 1998. Genetic and experimental evidence for cross-species infection by swine hepatitis E virus. J Virol 72 : 9714–9721.
  22. Matsuda H, Okada K, Takahashi K, Mishiro S, 2003. Severe hepatitis E virus infection after ingestion of uncooked liver from a wild boar. J Infect Dis 188 : 944.
  23. Tamada Y, Yano K, Yatsuhashi H, Inoue O, Mawatari F, Ishibashi H, 2004. Consumption of wild boar linked to cases of hepatitis E. J Hepatol 40 : 869–870.
  24. Yazaki Y, Mizuo H, Takahashi M, Nishizawa T, Sasaki N, Gotanda Y, Okamoto H, 2003. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J Gen Virol 84 : 2351–2357.
  25. Arankalle VA, Joshi MV, Kulkarni AM, Gandhe SS, Chobe LP, Rautmare SS, Mishra AC, Padbidri VS, 2001. Prevalence of anti-hepatitis E virus antibodies in different Indian animal species. J Viral Hepat 8 : 223–227.
  26. Chandler JD, Riddell MA, Li F, Love RJ, Anderson DA, 1999. Serological evidence for swine hepatitis E virus infection in Australian pig herds. Vet Microbiol 68 : 95–105.
  27. Clayson ET, Innis BL, Myint KS, Narupiti S, Vaughn DW, Giri S, Ranabhat P, Shrestha MP, 1995. Detection of hepatitis E virus infections among domestic swine in the Kathmandu Valley of Nepal. Am J Trop Med Hyg 53 : 228–232.
  28. Garkavenko O, Obriadina A, Meng J, Anderson DA, Benard HJ, Schroeder BA, Khudyakov YE, Fields HA, Croxson MC, 2001. Detection and characterisation of swine hepatitis E virus in New Zealand. J Med Virol 65 : 525–529.
  29. Takahashi M, Nishizawa T, Miyajima H, Gotanda Y, Iita T, Tsuda F, Okamoto H, 2003. Swine hepatitis E virus strains in Japan form four phylogenetic clusters comparable with those of Japanese isolates of human hepatitis E virus. J Gen Virol 84 : 851–862.
  30. Yoo D, Willson P, Pei Y, Hayes MA, Deckert A, Dewey CE, Friendship RM, Yoon Y, Gottschalk M, Yason C, Giulivi A, 2001. Prevalence of hepatitis E virus antibodies in Canadian swine herds and identification of a novel variant of swine hepatitis E virus. Clin Diagn Lab Immunol 8 : 1213–1219.
  31. Wang YC, Zhang HY, Xia NS, Peng G, Lan HY, Zhuang H, Zhu YH, Li SW, Tian KG, Gu WJ, Lin JX, Wu X, Li HM, Harrison TJ, 2002. Prevalence, isolation, and partial sequence analysis of hepatitis E virus from domestic animals in China. J Med Virol 67 : 516–521.
  32. Kasorndorkbua C, Guenette DK, Huang FF, Thomas PJ, Meng XJ, Halbur PG, 2004. Routes of transmission of Swine hepatitis e virus in pigs. J Clin Microbiol 42 : 5047–5052.
  33. Meng XJ, Halbur PG, Haynes JS, Tsareva TS, Bruna JD, Royer RL, Purcell RH, Emerson SU, 1998. Experimental infection of pigs with the newly identified swine hepatitis E virus (swine HEV), but not with human strains of HEV. Arch Virol 143 : 1405–1415.
  34. Williams TP, Kasorndorkbua C, Halbur PG, Haqshenas G, Guenette DK, Toth TE, Meng XJ, 2001. Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model. J Clin Microbiol 39 : 3040–3046.
  35. Li TC, Yamakawa Y, Suzuki K, Tatsumi M, Razak MA, Uchida T, Takeda N, Miyamura T, 1997. Expression and self-assembly of empty virus-like particles of hepatitis E virus. J Virol 71 : 7207–7213.
  36. Tanaka H, Yoshino H, Kobayashi E, Takahashi M, Okamoto H, 2004. Molecular investigation of hepatitis E virus infection in domestic and miniature pigs used for medical experiments. Xenotransplantation 11 : 503–510.
  37. Takahashi K, Kang JH, Ohnishi S, Hino K, Mishiro S, 2002. Genetic heterogeneity of hepatitis E virus recovered from Japanese patients with acute sporadic hepatitis. J Infect Dis 185 : 1342–1345.
  38. Huang FF, Haqshenas G, Guenette DK, Halbur PG, Schommer SK, Pierson FW, Toth TE, Meng XJ, 2002. Detection by reverse transcription-PCR and genetic characterization of field isolates of swine hepatitis E virus from pigs in different geographic regions of the United States. J Clin Microbiol 40 : 1326–1332.
  39. Thompson JD, Higgins DG, Gibson TJ, 1994. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22 : 4673–4680.
  40. Page RDM, 1996. TREEVIEW: An application to display phylogenetic trees on personal computers. Comput Appl Biosci 12 : 357–358.
  41. Roth IA, 1999. The immune system. Straw BE, D’Allaire S, Mengeling WL, Taylor DT, eds. Diseases of Swine. Ames, IA: Iowa State University Press, 799–820.
  42. Kasorndorkbua C, Thacker BJ, Halbur PG, Guenette DK, Buitenwerf RM, Royer RL, Meng XJ, 2003. Experimental infection of pregnant gilts with swine hepatitis E virus. Can J Vet Res 67 : 303–306.
  43. Takahashi M, Nishizawa T, Tanaka T, Tsatsralt-Od B, Inoue J, Okamoto H, 2005. Correlation between positivity for immunoglobulin A antibodies and viraemia of swine hepatitis E virus observed among farm pigs in Japan. J Gen Virol 86 : 1807–1813.
  44. Choi IS, Kwon HJ, Shin NR, Yoo HS, 2003. Identification of swine hepatitis E virus (HEV) and prevalence of anti-HEV antibodies in swine and human populations in Korea. J Clin Microbiol 41 : 3602–3608.
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  • Received : 28 Apr 2006
  • Accepted : 03 Jul 2006

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