1921
Volume 75, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Recently, we reported the discovery of several potential rodent reservoirs of hantaviruses in western () and eastern Paraguay ( and ). Comparisons of the hantavirus S- and M-segments amplified from these four rodents revealed significant differences from each another and from other South American hantaviruses. The ALP strain from the semiarid Chaco ecoregion clustered with Leguna Negra and Rio Mamore (LN/RM), whereas the BMJ-ÑEB strain from the more humid lower Chaco ecoregion formed a clade with Oran and Bermejo. The other two strains, AAI and IP37/38, were distinct from known hantaviruses. With respect to the S-segment sequence, AAI from eastern Paraguay formed a clade with ALP/LN/RM, but its M-segment clustered with Pergamino and Maciel, suggesting a possible reassortment. AAI was found in areas experiencing rapid land cover fragmentation and change within the Interior Atlantic Forest. IP37/38 did not show any strong association with any of the known hantavirus strains.

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2006-12-01
2017-09-20
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References

  1. Hjelle B, Yates T, 2001. Modeling hantavirus maintenance and transmission in rodent communities. Curr Top Microbiol Immunol 256 : 77–90.
  2. Plyusnin A, Morzunov SP, 2001. Virus evolution and genetic diversity of hantaviruses and their rodent hosts. Curr Top Microbiol Immunol 256 : 47–75.
  3. Plyusnin A, 2002. Genetics of hantaviruses: Implications to taxonomy. Arch Virol 147 : 665–682.
  4. Glass GE, Childs JE, Korch GW, LeDuc JW, 1988. Association of intraspecific wounding with hantaviral infection in wild rats (Rattus norvegicus). Epidemiol Infect 101 : 459–472.
  5. Hinson ER, Shone SM, Zink MC, Glass GE, Klein SL, 2004. Wounding: The primary mode of Seoul virus transmission among male Norway rats. Am J Trop Med Hyg 70 : 310–317.
  6. Root JJ, Black WCt, Calisher CH, Wilson KR, Beaty BJ, 2004. Genetic relatedness of deer mice (Peromyscus maniculatus) infected with Sin Nombre virus. Vector Borne Zoonotic Dis 4 : 149–157.
  7. Lee HW, Lee PW, Baek LJ, Song CK, Seong IW, 1981. Intraspecific transmission of Hantaan virus, etiologic agent of Korean hemorrhagic fever, in the rodent Apodemus agrarius. Am J Trop Med Hyg 30 : 1106–1112.
  8. Kariwa H, Fujiki M, Yoshimatsu K, Arikawa J, Takashima I, Hashimoto N, 1998. Urine-associated horizontal transmission of Seoul virus among rats. Arch Virol 143 : 365–374.
  9. Bernshtein AD, Apekina NS, Mikhailova TV, Myasnikov YA, Khlyap LA, Korotkov YS, Gavrilovskaya IN, 1999. Dynamics of Puumala hantavirus infection in naturally infected bank voles (Clethrinomys glareolus). Arch Virol 144 : 2415–2428.
  10. Hutchinson KL, Rollin PE, Shieh WJ, Zaki S, Greer PW, Peters CJ, 2000. Transmission of Black Creek Canal virus between cotton rats. J Med Virol 60 : 70–76.
  11. Iwasa MA, Kariwa H, Cui BZ, Lokugamage K, Lokugamage N, Hagiya T, Mizutani T, Takashima I, 2004. Modes of hantavirus transmission in a population of Clethrionomys rufocanus bedfordiae inferred from mitochondrial and microsatellite DNA analyses. Arch Virol 149 : 929–941.
  12. Li D, Schmaljohn AL, Anderson K, Schmaljohn CS, 1995. Complete nucleotide sequences of the M and S segments of two hantavirus isolates from California: Evidence for reassortment in nature among viruses related to hantavirus pulmonary syndrome. Virology 206 : 973–983.
  13. Plyusnin A, Cheng Y, Vapalahti O, Pejcoch M, Unar J, Jelinkova Z, Lehvaslaiho H, Lundkvist A, Vaheri A, 1995. Genetic variation in Tula hantaviruses: Sequence analysis of the S and M segments of strains from Central Europe. Virus Res 39 : 237–250.
  14. Rodriguez LL, Owens JH, Peters CJ, Nichol ST, 1998. Genetic reassortment among viruses causing hantavirus pulmonary syndrome. Virology 242 : 99–106.
  15. McElroy AK, Smith JM, Hooper JW, Schmaljohn CS, 2004. Andes virus M genome segment is not sufficient to confer the virulence associated with Andes virus in Syrian hamsters. Virology 326 : 130–139.
  16. Henderson WW, Monroe MC, St Jeor SC, Thayer WP, Rowe JE, Peters CJ, Nichol ST, 1995. Naturally occurring Sin Nombre virus genetic reassortants. Virology 214 : 602–610.
  17. Lee HW, Johnson KM, 1982. Laboratory-acquired infections with Hantaan virus, the etiologic agent of Korean hemorrhagic fever. J Infect Dis 146 : 645–651.
  18. Tsai TF, 1987. Hemorrhagic fever with renal syndrome: Mode of transmission to humans. Lab Anim Sci 37 : 428–430.
  19. Padula PJ, Edelstein A, Miguel SD, Lopez NM, Rossi CM, Rabinovich RD, 1998. Hantavirus pulmonary syndrome outbreak in Argentina: molecular evidence for person-to-person transmission of Andes virus. Virology 241 : 323–330.
  20. LeDuc JW, Childs JE, Glass GE, 1992. The Hantaviruses, etiologic agents of hemorrhagic fever with renal syndrome: a possible cause of hypertension and chronic renal disease in the United States. Annu Rev Public Health 13 : 79–98.
  21. Peters CJ, Khan AS, 2002. Hantavirus pulmonary syndrome: the new American hemorrhagic fever. Clin Infect Dis 34 : 1224–1231.
  22. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917.
  23. Schmaljohn C, Hjelle B, 1997. Hantaviruses: a global disease problem. Emerg Infect Dis 3 : 95–104.
  24. Levis S, Morzunov SP, Rowe JE, Enria D, Pini N, Calderon G, Sabattini M, St Jeor SC, 1998. Genetic diversity and epidemiology of hantaviruses in Argentina. J Infect Dis 177 : 529–538.
  25. Calderon G, Pini N, Bolpe J, Levis S, Mills J, Segura E, Guthmann N, Cantoni G, Becker J, Fonollat A, Ripoll C, Bortman M, Benedetti R, Enria D, 1999. Hantavirus reservoir hosts associated with peridomestic habitats in Argentina. Emerg Infect Dis 5 : 792–797.
  26. Bharadwaj M, Botten J, Torrez-Martinez N, Hjelle B, 1997. Rio Mamore virus: genetic characterization of a newly recognized hantavirus of the pygmy rice rat, Oligoryzomys microtis, from Bolivia. Am J Trop Med Hyg 57 : 368–374.
  27. Figueiredo LT, Moreli ML, Campos GM, Sousa RL, 2003. Hantaviruses in Sao Paulo State, Brazil. Emerg Infect Dis 9 : 891–892.
  28. Toro J, Vega JD, Khan AS, Mills JN, Padula P, Terry W, Yadon Z, Valderrama R, Ellis BA, Pavletic C, Cerda R, Zaki S, Shieh WJ, Meyer R, Tapia M, Mansilla C, Baro M, Vergara JA, Concha M, Calderon G, Enria D, Peters CJ, Ksiazek TG, 1998. An outbreak of hantavirus pulmonary syndrome, Chile, 1997. Emerg Infect Dis 4 : 687–694.
  29. Hjelle B, Anderson B, Torrez-Martinez N, Song W, Gannon WL, Yates TL, 1995. Prevalence and geographic genetic variation of hantaviruses of New World harvest mice (Reithrodontomys): identification of a divergent genotype from a Costa Rican Reithrodontomys mexicanus. Virology 207 : 452–459.
  30. Vincent MJ, Quiroz E, Gracia F, Sanchez AJ, Ksiazek TG, Kitsutani PT, Ruedas LA, Tinnin DS, Caceres L, Garcia A, Rollin PE, Mills JN, Peters CJ, Nichol ST, 2000. Hantavirus pulmonary syndrome in Panama: Identification of novel hantaviruses and their likely reservoirs. Virology 277 : 14–19.
  31. Powers AM, Mercer DR, Watts DM, Guzman H, Fulhorst CF, Popov VL, Tesh RB, 1999. Isolation and genetic characterization of a hantavirus (Bunyaviridae: Hantavirus) from a rodent, Oligoryzomys microtis (Muridae), collected in northeastern Peru. Am J Trop Med Hyg 61 : 92–98.
  32. Fulhorst CF, Monroe MC, Salas RA, Duno G, Utrera A, Ksiazek TG, Nichol ST, de Manzione NM, Tovar D, Tesh RB, 1997. Isolation, characterization and geographic distribution of Cano Delgadito virus, a newly discovered South American hantavirus (family Bunyaviridae). Virus Res 51 : 159–171.
  33. Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST, 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238 : 115–127.
  34. Chu YK, Owen RD, Gonzalez LM, Jonsson CB, 2003. The complex ecology of hantavirus in Paraguay. Am J Trop Med Hyg 69 : 263–268.
  35. Chu YK, Jennings G, Schmaljohn A, Elgh F, Hjelle B, Lee H-W, Jenison S, Ksiazek T, Peters CJ, Rollin P, Schmaljohn C, 1995. Cross-neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. J Infect Dis 172 : 1581–1584.
  36. Bohlman MC, Morzunov SP, Meissner J, Taylor MB, Ishibashi K, Rowe J, Levis S, Enria D, St Jeor SC, 2002. Analysis of hantavirus genetic diversity in Argentina: S segment-derived phylogeny. J Virol 76 : 3765–3773.
  37. Padula PJ, Colavecchia SB, Martinez VP, Gonzalez Della Valle MO, Edelstein A, Miguel SD, Russi J, Riquelme JM, Colucci N, Almiron M, Rabinovich RD, 2000. Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America. J Clin Microbiol 38 : 3029–3035.
  38. Doyle TJ, Bryan RT, Peters CJ, 1998. Viral hemorrhagic fevers and hantavirus infections in the Americas. Infect Dis Clin North Am 12 : 95–110.
  39. Sanchez AJ, Abbott KD, Nichol ST, 2001. Genetic identification and characterization of limestone canyon virus, a unique Peromyscus-borne hantavirus. Virology 286 : 345–353.
  40. Engel SR, Hogan KM, Taylor JF, Davis SK, 1998. Molecular systematics and paleobiogeography of the South American sigmodontine rodents. Mol Biol Evol 15 : 35–49.
  41. Pardiñas U, D’Elía G, Ortiz P, 2002. Sigmodontinos fosiles (Rodentia, Muroidea, Sigmodontinea) de América del Sur: Estado actual de conocimiento y prospectivo. Mastozoología Neotropical 9 : 209–252.
  42. D’Elía G, 2003. Phylogenetics of Sigmodontinae (Rodentia, Muroidea, Cricetidae), with special reference to the akodont group, and with additional comments on biogeography. Cladistics 19 : 307–323.
  43. Klempa B, Schmidt HA, Ulrich R, Kaluz S, Labuda M, Meisel H, Hjelle B, Kruger DH, 2003. Genetic interaction between distinct Dobrava hantavirus subtypes in Apodemus agrarius and A. flavicollis in nature. J Virol 77 : 804–809.
  44. Olson DM, Dinerstein E, Wikramanayake ED, Burgess ND, Powell GVN, Underwood EC, D’Amico JA, Itoua I, Strand HE, Morrinson JC, Loucks CJ, Allnutt TF, Ricketts TH, Kura Y, Lamoreux JF, Wettengel WW, Hedao P, Kassem KR, 2001. Terrestrial ecoregions of the world: A new map of life on earth. Bioscience 51 : 933–938.
  45. Schmaljohn AL, Li D, Negley DL, Bressler DS, Turell MJ, Korch GW, Ascher MS, Schmaljohn CS, 1995. Isolation and initial characterization of a newfound hantavirus from California. Virology 206 : 963–972.
  46. Hjelle B, Lee SW, Song W, Torrez-Martinez N, Song JW, Yanagihara R, Gavrilovskaya I, Mackow ER, 1995. Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: Genetic characterization of the M genome of New York virus. J Virol 69 : 8137–8141.
  47. Song JW, Baek LJ, Gavrilovskaya IN, Mackow ER, Hjelle B, Yanagihara R, 1996. Sequence analysis of the complete S genomic segment of a newly identified hantavirus isolated from the white-footed mouse (Peromyscus leucopus): Phylogenetic relationship with other sigmodontine rodent-borne hantaviruses. Virus Genes 12 : 249–256.
  48. Morzunov SP, Rowe JE, Ksiazek TG, Peters CJ, St Jeor SC, Nichol ST, 1998. Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol 72 : 57–64.
  49. Ravkov EV, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1995. Genetic and serologic analysis of Black Creek Canal virus and its association with human disease and Sigmodon hispidus infection. Virology 210 : 482–489.
  50. Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1995. A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. J Virol 69 : 1980–1983.
  51. Rawlings JA, Torrez-Martinez N, Neill SU, Moore GM, Hicks BN, Pichuantes S, Nguyen A, Bharadwaj M, Hjelle B, 1996. Cocirculation of multiple hantaviruses in Texas, with characterization of the small (S) genome of a previously undescribed virus of cotton rats (Sigmodon hispidus). Am J Trop Med Hyg 55 : 672–679.
  52. Torrez-Martinez N, Song W, Hjelle B, 1995. Nucleotide sequence analysis of the M genomic segment of El Moro Canyon hantavirus: Antigenic distinction from four corners hantavirus. Virology 211 : 336–338.
  53. Hjelle B, Chavez-Giles F, Torrez-Martinez N, Yates T, Sarisky J, Webb J, Ascher M, 1994. Genetic identification of a novel hantavirus of the harvest mouse Reithrodontomys megalotis. J Virol 68 : 6751–6754.
  54. Meissner JD, Rowe JE, Borucki MK, St Jeor SC, 2002. Complete nucleotide sequence of a Chilean hantavirus. Virus Res 89 : 131–143.
  55. Padula PJ, Sanchez AJ, Edelstein A, Nichol ST, 2002. Complete nucleotide sequence of the M RNA segment of Andes virus and analysis of the variability of the termini of the virus S, M and L RNA segments. J Gen Virol 83 : 2117–2122.
  56. Lopez N, Padula P, Rossi C, Miguel S, Edelstein A, Ramirez E, Franze-Fernandez MT, 1997. Genetic characterization and phylogeny of Andes virus and variants from Argentina and Chile. Virus Res 50 : 77–84.
  57. Johnson AM, de Souza LT, Ferreira IB, Pereira LE, Ksiazek TG, Rollin PE, Peters CJ, Nichol ST, 1999. Genetic investigation of novel hantaviruses causing fatal HPS in Brazil. J Med Virol 59 : 527–535.
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  • Received : 04 Jan 2006
  • Accepted : 05 Jul 2006

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