Volume 75, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Here we report a documented case of congenital transmission of from a Bolivian mother with chronic Chagas disease living in Spain. The serology and blood nested polymerase chain reaction (PCR) were positive for the mother, and amastigote forms were observed in histopathological study of the placenta and umbilical cord. Direct examination, culture, and nested PCR were positive in the blood of the neonate. At the age of 8 days, the neonate began treatment with 5–7.5 mg/kg/day of benznidazol, which was continued for 60 days. Direct examination, blood culture, and nested PCR were negative to 20 days after the start of treatment and remained negative 4 and 7 months thereafter. Serological tests were negative at 4 months. To detect congenital infection and initiate early treatment of infected newborns, protocols are required to detect Chagas disease in pregnant women who migrate from endemic to non-endemic areas.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Prata A, 2001. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 1 : 92–100. [Google Scholar]
  2. Benchimol Barbosa PR, 2006. The oral transmission of Chagas’ disease: An acute form of infection responsible for regional outbreaks. Int J Cardiol.
  3. Pehrson PO, Wahlgren M, Bengtsson E, 1981. Asymptomatic congenital Chagas’ disease in a 5-year-old child. Scand J Infect Dis 13 : 307–308. [Google Scholar]
  4. Marcon GE, Andrade PD, de Albuquerque DM, Wanderley da Silva J, de Almeida EA, Guariento ME, Costa SC, 2002. Use of a nested-polymerase chain reaction (N-PCR) to detect Trypanosoma cruzi in blood samples from chronic chagasic patients and patients with doubtful serologies. Diag Microbial Infect Dis 43 : 39–43. [Google Scholar]
  5. Bittencourt AL, 2000. Transmissiao vertical da doença de Chagas. Brener Z, Andrade ZA, Barral-Netto M, eds. Trypanosoma cruzi e doença de Chagas. Second edition. Rio de Janeiro: Editora Guanabara Koogan SA, 16–20.
  6. Okumura M, Aparecida dos Santos V, Camargo ME, Schultz R, Zugaib M, 2004. Prenatal diagnosis of congenital Chagas’ disease (American trypanosomiasis). Prenat Diagn 24 : 179–181. [Google Scholar]
  7. Moretti E, Basso B, Castro I, Carrizo Paez M, Chaul M, Barbieri G, Canal Feijoo D, Sartori MJ, Carrizo Paez R, 2005. Chagas’ disease: Study of congenital transmission in cases of acute maternal infection. Rev Soc Bras Med Trop 38 : 53–55. [Google Scholar]
  8. Bittencourt AL, 1992. Possible risk factors for vertical transmission of Chagas’ disease. Rev Inst Med Trop Sao Paulo 34 : 403–408. [Google Scholar]
  9. Reiche EM, Inouye MM, Bonametti AM, Jankevicius X, 1996. Congenital Chagas disease: Epidemiology, laboratorial diagnosis, prognosis and treatment. J Pediatr 72 : 125–132. [Google Scholar]
  10. Hermann E, Truyens C, Alonso-Vega C, Rodriguez P, Berthe A, Torrico F, Carlier Y, 2004. Congenital transmission of Trypanosoma cruzi is associated with maternal enhanced parasitemia and decreased production of interferon-gamma in response to parasite antigens. J Infect Dis 189 : 1274–1281. [Google Scholar]
  11. Hernandez-Matheson IM, Frankowski RF, Held B, 1983. Foeto-maternal morbidity in the presence of antibodies to Trypanosoma cruzi. Trans R Soc Trop Med Hyg 77 : 405. [Google Scholar]
  12. Blanco SB, Segura EL, Cura EN, Chuit R, Tulian L, Flores I, Garbarino G, Villalonga JF, Gurtler RE, 2000. Congenital transmission of Trypanosoma cruzi: An operational outline for detecting and treating infected infants in north-western Argentina. Trop Med Int Health 5 : 293–301. [Google Scholar]
  13. Torrico F, Alonso-Vega C, Suarez E, Rodriguez P, Torrico MC, Dramaix M, Truyens C, Carlier Y, 2004. Maternal Trypanosoma cruzi infection, pregnancy outcome, morbidity, and mortality of congenitally infected and non-infected newborns in Bolivia. Am J Trop Med Hyg 70 : 201–209. [Google Scholar]
  14. Moya P, Moretti E, Basso B, Blanco S, Sanmartino C, de Cura AS, 1989. Enfermedad de Chagas neonatal, diagnóstico de laboratorio en el primer año de vida. Medicina (B Aires) 49 : 595–599. [Google Scholar]
  15. Robert-Gangneux F, Commerce V, Tourte-Schaefer C, Dupouy-Camet J, 1999. Performance of a Western blot assay to compare mother and newborn anti-Toxoplasma antibodies for the early neonatal diagnosis of congenital toxoplasmosis. Eur J Clin Microbiol Infect Dis 18 : 648–655. [Google Scholar]
  16. Virreira M, Torrico F, Truyens C, Alonso-Vega C, Solano M, Carlier Y, Svoboda M, 2003. Comparison of polymerase chain reaction methods for reliable and easy detection of congenital Trypanosoma cruzi infection. Am J Trop Med Hyg 68 : 574–582. [Google Scholar]
  17. Schijman AG, Altcheh J, Burgos JM, Biancardi M, Bisio M, Levin MJ, Freilij H, 2003. Aetiological treatment of congenital Chagas’ disease diagnosed and monitored by the polymerase chain reaction. J Antimicrob Chemother 52 : 441–449. [Google Scholar]
  18. Russomando G, de Tomassone MM, de Guillen I, Acosta N, Vera N, Almiron M, Candia N, Calcena MF, Figueredo A, 1998. Treatment of congenital Chagas’ disease diagnosed and followed up by the polymerase chain reaction. Am J Trop Med Hyg 59 : 487–491. [Google Scholar]

Data & Media loading...

  • Received : 05 Jan 2006
  • Accepted : 05 Jul 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error