Volume 75, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The primary objective of this study was to extend our knowledge of the geographical distribution, genetic diversity, and natural host associations of the hantaviruses indigenous to North America. Antibody to a hantavirus was found in 5 (20.8%) of 24 Coues’ oryzomys () and none of 41 other rodents captured near the town of Catacamas in eastern Honduras, and a hantavirus was isolated from one of the antibody-positive Coues’ oryzomys. Analyses of nucleotide and amino acid sequence data indicated that the viral isolate is a strain of a novel hantaviral species (proposed species name “”) that is phylogenetically most closely related to a hantaviral species that is principally associated with (marsh oryzomys) in the southeastern United States. is the first evidence for the occurrence of a hantaviral species in Honduras and the first evidence that a hantaviral species is naturally associated with an species other than


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Khan AS, Spiropoulou CF, Morzunov S, Zaki SR, Kohn MA, Nawas SR, McFarland L, Nichol ST, 1995. Fatal illness associated with a new hantavirus in Louisiana. J Med Virol 46 : 281–286. [Google Scholar]
  2. Morzunov SP, Feldmann H, Spiropoulou CF, Semenova VA, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1995. A newly recognized virus associated with a fatal case of hantavirus pulmonary syndrome in Louisiana. J Virol 69 : 1980–1983. [Google Scholar]
  3. Khan AS, Gaviria M, Rollin PE, Hlady WG, Ksiazek TG, Armstrong LR, Greenman R, Ravkov E, Kolber M, Anapol H, Sfakianaki ED, Nichol ST, Peters CJ, Khabbaz RF, 1996. Hantavirus pulmonary syndrome in Florida: association with the newly identified Black Creek Canal virus. Am J Med 100 : 46–48. [Google Scholar]
  4. Hjelle B, Lee SW, Song W, Torrez-Martinez N, Song JW, Yanagihara R, Gavrilovskaya I, Mackow ER, 1995. Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus. J Virol 69 : 8137–8141. [Google Scholar]
  5. Drebot MA, Gavrilovskaya I, Mackow ER, Chen Z, Lindsay R, Sanchez AJ, Nichol ST, Artsob H, 2001. Genetic and serotypic characterization of Sin Nombre-like viruses in Canadian Peromyscus maniculatus mice. Virus Res 75 : 75–86. [Google Scholar]
  6. Nichol ST, Spiropoulou CF, Morzunov S, Rollin PE, Ksiazek TG, Feldmann H, Sanchez A, Childs J, Zaki S, Peters CJ, 1993. Genetic identification of a hantavirus associated with an outbreak of acute respiratory illness. Science 262 : 914–917. [Google Scholar]
  7. Vincent MJ, Quiroz E, Gracia F, Sanchez AJ, Ksiazek TG, Kitsutani PT, Ruedas LA, Tinnin DS, Caceres L, Garcia A, Rollin PE, Mills JN, Peters CJ, Nichol ST, 2000. Hantavirus pulmonary syndrome in Panama: identification of novel hantaviruses and their likely reservoirs. Virology 277 : 14–19. [Google Scholar]
  8. Gonzalez Della Valle M, Edelstein A, Miguel S, Martinez V, Cortez J, Cacace ML, Jurgelenas G, Estani SS, Padula P, 2002. Andes virus associated with hantavirus pulmonary syndrome in northern Argentina and determination of the precise site of infection. Am J Trop Med Hyg 66 : 713–720. [Google Scholar]
  9. López N, Padula P, Rossi C, Lázaro ME, Franze-Fernández MT, 1996. Genetic identification of a new hantavirus causing severe pulmonary syndrome in Argentina. Virology 220 : 223–226. [Google Scholar]
  10. Meissner JD, Rowe JE, Borucki MK, St Jeor SC, 2002. Complete nucleotide sequence of a Chilean hantavirus. Virus Res 89 : 131–143. [Google Scholar]
  11. Johnson AM, Bowen MD, Ksiazek TG, Williams RJ, Bryan RT, Mills JN, Peters CJ, Nichol ST, 1997. Laguna Negra virus associated with HPS in western Paraguay and Bolivia. Virology 238 : 115–127. [Google Scholar]
  12. Levis S, Garcia J, Pini N, Calderon G, Ramirez J, Bravo D, St Jeor S, Ripoll C, Bego M, Lozano E, Barquez R, Ksiazek TG, Enria D, 2004. Hantavirus pulmonary syndrome in northwestern Argentina: circulation of Laguna Negra virus associated with Calomys callosus. Am J Trop Med Hyg 71 : 658–663. [Google Scholar]
  13. Torrez-Martinez N, Song W, Hjelle B, 1995. Nucleotide sequence analysis of the M genomic segment of El Moro Canyon hantavirus: antigenic distinction from Four Corners hantavirus. Virology 211 : 336–338. [Google Scholar]
  14. Rawlings JA, Torrez-Martinez N, Neill SU, Moore GM, Hicks BN, Pichuantes S, Nguyen A, Bharadwaj M, Hjelle B, 1996. Cocirculation of multiple hantaviruses in Texas, with characterization of the small (S) genome of a previously undescribed virus of cotton rats (Sigmodon hispidus). Am J Trop Med Hyg 55 : 672–679. [Google Scholar]
  15. Hjelle B, Anderson B, Torrez-Martinez N, Song W, Gannon WL, Yates TL, 1995. Prevalence and geographic genetic variation of hantaviruses of New World harvest mice (Reithrodontomys): identification of a divergent genotype from a Costa Rican Reithrodontomys mexicanus. Virology 207 : 452–459. [Google Scholar]
  16. Fulhorst CF, Monroe MC, Salas RA, Duno G, Utrera A, Ksiazek TG, Nichol ST, de Manzione NMC, Tovar D, Tesh RB, 1997. Isolation, characterization, and geographic distribution of Caño Delgadito virus, a newly discovered South American hantavirus (family Bunyaviridae). Virus Res 51 : 159–171. [Google Scholar]
  17. Fulhorst CF, Cajimat MNB, Utrera A, Milazzo ML, Duno GM, 2004. Maporal virus, a hantavirus associated with the fulvous pygmy rice rat (Oligoryzomys fulvescens) in western Venezuela. Virus Res 104 : 139–144. [Google Scholar]
  18. Bharadwaj M, Botten J, Torrez-Martinez N, Hjelle B, 1997. Rio Mamore virus: genetic characterization of a newly recognized hantavirus of the pygmy rice rat, Oligoryzomys microtis, from Bolivia. Am J Trop Med Hyg 57 : 368–374. [Google Scholar]
  19. Hall ER, 1981. The Mammals of North America. Volume II. New York: John Wiley & Sons, Inc., 601–1181.
  20. Fulhorst CF, Milazzo ML, Duno G, Salas RA, 2002. Experimental infection of the Sigmodon alstoni cotton rat with Caño Delgadito virus, a South American hantavirus. Am J Trop Med Hyg 67 : 107–111. [Google Scholar]
  21. Tesh RB, Wilson ML, Salas R, de Manzione NM, Tovar D, Ksiazek TG, Peters CJ, 1993. Field studies on the epidemiology of Venezuelan hemorrhagic fever: implication of the cotton rat Sigmodon alstoni as the probable rodent reservoir. Am J Trop Med Hyg 49 : 227–235. [Google Scholar]
  22. Nichol ST, Beaty BJ, Elliott RM, Goldbach R, Plyusnin A, Schmaljohn CS, Tesh RB, 2005. Family Bunyaviridae. Fauquet CM, Mayo MA, Maniloff J, Desselberger U, Ball LA, eds. Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses.San Diego, CA: Elsevier Academic Press, 695–716.
  23. Plyusnin A, Vapalahti O, Vaheri A, 1996. Hantaviruses: genome structure, expression, and evolution. J Gen Virol 77 : 2677–2687. [Google Scholar]
  24. Thompson JD, Higgins DG, Gibson TJ, 1994. CLUSTAL W (1.7): improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choices. Nucleic Acids Res 22 : 4673–4680. [Google Scholar]
  25. Kumar S, Tamura K, Jakobsen IB, Nei M, 2001. MEGA2: molecular evolutionary genetics analysis software. Bioinformatics 17 : 1244–1245. [Google Scholar]
  26. Swofford DL, 2003. PAUP*. Phylogenetic Analysis Using Parsimony (*and Other Methods), version 4. Sunderland, MA: Sinauer Associates.
  27. Felsentein J, 1985. Confidence limits on phylogenies: an approach using the bootstrap. Evolution Int J Org Evolution 39 : 783–791. [Google Scholar]
  28. Ksiazek TG, Nichol ST, Mills JN, Groves MG, Wozniak A, McAdams S, Monroe MC, Johnson AM, Martin ML, Peters CJ, Rollin PE, 1997. Isolation, genetic diversity, and geographic distribution of Bayou virus (Bunyaviridae: hantavirus). Am J Trop Med Hyg 57 : 445–448. [Google Scholar]
  29. Smith MF, Patton JL, 1999. Phylogenetic relationships and the radiation of sigmodontine rodents in South America: evidence from cytochrome b. J Mammal Evol 6 : 89–128. [Google Scholar]
  30. Smith MF, Patton JL, 1993. The diversification of South American rodents: evidence from mitochondrial sequence data for the akodontine tribe. Biol J Linn Soc 50 : 149–177. [Google Scholar]
  31. Mendez-Harclerode FM, Hanson JD, Fulhorst CF, Milazzo ML, Ruthven DC III, Bradley RD, 2005. Genetic diversity within the southern plains woodrat (Neotoma micropus) in southern Texas. J Mammal 86 : 180–190. [Google Scholar]
  32. Irwin DM, Kocher TD, Wilson AC, 1991. Evolution of the cytochrome b gene in mammals. J Mol Evol 32 : 138–144. [Google Scholar]
  33. Whiting AS, Bauer AM, Sites JW Jr, 2003. Phylogenetic relationships and limb loss in sub-Saharan African scincine lizards (Squamata: Scinicidae). Mol Phylogenet Evol 29 : 582–598. [Google Scholar]
  34. Tiemann-Boege I, Kilpatrick CW, Schmidly DJ, Bradley RD, 2000. Molecular phylogenetics of the Peromyscus boylii species group (Rodentia: Muridae) based on mitochondrial cytochrome b sequences. Mol Phylogenet Evol 16 : 366–378. [Google Scholar]
  35. Peppers LL, Bradley RD, 2000. Cryptic speciation in Sigmodon hispidus: evidence from DNA sequences. J Mammal 81 : 332–343. [Google Scholar]
  36. Peppers LL, Carroll DS, Bradley RD, 2002. Molecular systematics of the genus Sigmodon (Rodentia: Muridae): evidence from the mitochondrial cytochrome b gene. J Mammal 83 : 396–407. [Google Scholar]
  37. Myers P, Lundrigan B, Tucker PK, 1995. Molecular phylogenetics of oryzomyine rodents: the genus Oligoryzomys. Mol Phylogenet Evol 4 : 372–382. [Google Scholar]
  38. Bonivicino CR, Moreira MAM, 2001. Molecular phylogeny of the genus Oryzomys (Rodentia: Sigmodontinae) based on cytochrome b DNA sequences. Mol Phylogenet Evol 18 : 282–292. [Google Scholar]
  39. Huelsenbeck JP, Ronquist F, 2001. MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 17 : 754–755. [Google Scholar]
  40. Ronquist F, Huelsenbeck JP, 2003. MrBayes 3: Bayesian phylogenetic inference under mixed models. Bioinformatics 19 : 1572–1574. [Google Scholar]
  41. Ravkov EV, Rollin PE, Ksiazek TG, Peters CJ, Nichol ST, 1995. Genetic and serologic analysis of Black Creek Canal virus and its association with human disease and Sigmodon hispidus infection. Virology 210 : 482–489. [Google Scholar]
  42. Bohlman MC, Morzunov SP, Meissner J, Taylor MB, Ishibashi K, Rowe J, Levis S, Enria D, St Jeor SC, 2002. Analysis of hantavirus genetic diversity in Argentina: S segment-derived phylogeny. J Virol 76 : 3765–3773. [Google Scholar]
  43. Padula P, Figueroa R, Navarrete M, Pizarro E, Cadiz R, Bellomo C, Jofre C, Zaror L, Rodríguez E, Murúa R, 2004. Transmission study of Andes hantavirus infection in wild sigmodontine rodents. J Virol 78 : 11972–11979. [Google Scholar]
  44. Reid FA, 1997. A Field Guide to the Mammals of Central America and Southeast Mexico. New York: Oxford University Press, 334 pp.
  45. Schmidly DJ, 2004. Mammals of Texas. Sixth Edition. Austin, TX: University of Texas Press, 501 pp.
  46. Schmidt CA, Engstrom MD, 1994. Genic variation and systematics of rice rats (Oryzomys palustris species group) in southern Texas and northeastern Tamaulipas, Mexico. J Mammal 75 : 914–928. [Google Scholar]
  47. Wilson DE, Reeder DM, 2005. Mammal Species of the World. A Taxonomic and Geographic Reference. Third Edition. Baltimore, MD: Johns Hopkins University Press, 2142 pp.
  48. Benson DL, Gehlbach FR, 1979. Ecological and taxonomic notes on the rice rat (Oryzomys couesi) in Texas. J Mammal 60 : 225–228. [Google Scholar]
  49. Childs JE, Ksiazek TG, Spiropoulou CF, Krebs JW, Morzunov S, Maupin GO, Gage KL, Rollin PE, Sarisky J, Enscore RE, 1994. Serologic and genetic identification of Peromyscus maniculatus as the primary rodent reservoir for a new hantavirus in the southwestern United States. J Infect Dis 169 : 1271–1280. [Google Scholar]
  50. Morzunov SP, Rowe JE, Ksiazek TG, Peters CJ, St Jeor SC, Nichol ST, 1998. Genetic analysis of the diversity and origin of hantaviruses in Peromyscus leucopus mice in North America. J Virol 72 : 57–64. [Google Scholar]
  51. Song JW, Baek LJ, Gajdusek DC, Yanagihara R, Gavrilovskaya L, Luft BJ, Mackow ER, Hjelle B, 1994. Isolation of pathogenic hantavirus from white-footed mouse (Peromyscus leucopus). Lancet 344 : 1637. [Google Scholar]
  52. Armien B, Pascale JM, Bayard V, Munoz C, Mosca I, Guerrero G, Armien A, Quiroz E, Castillo Z, Zaldivar Y, Gracia F, Hjelle B, Koster F, 2004. High seroprevalence of hantavirus infection on the Azuero peninsula of Panama. Am J Trop Med Hyg 70 : 682–687. [Google Scholar]

Data & Media loading...

  • Received : 13 Apr 2006
  • Accepted : 10 Jul 2006

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error