Volume 74, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


A combined (human and porcine) mass chemotherapy program was tested in a controlled design in 12 village hamlets in the Peruvian highlands. A single dose of 5 mg of praziquantel was given to eliminate intestinal taeniasis in humans, and two rounds of oxfendazole (30 mg/kg) were administered to all pigs. The total population in the study villages was 5,658 resident individuals, and the porcine population at the beginning of the study was 716 pigs. Human treatment coverage was 75%, ranging from 69% to 80%. There were only a few refusals of owners for porcine treatment of their animals. The effect of the intervention was measured by comparing incidence rates (seroconversion in pigs who were seronegative 4 months before) in treatment versus control villages, before and up to 18 months after treatment. There was a clear effect in decreasing prevalence (odds ratio, 0.51; < 0.001) and incidence (odds ratio, 0.39; < 0.013) in the treatment area after the intervention, which did not leave to extinction of the parasite but stabilized in slightly decreased rates persisting along the follow-up period. Mass chemotherapy was effective in decreasing infection pressure in this hyperendemic area. However, the magnitude of the effect was small and did not attain the goal of eliminating transmission.


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  1. Garcia HH, Gonzalez AE, Evans CAW, Gilman RH, the Cysticercosis Working Group in Peru., 2003. Taenia solium cysticercosis. Lancet 362 : 547–556. [Google Scholar]
  2. Roman G, Sotelo J, Del Brutto O, Flisser A, Dumas M, Wadia N, Botero D, Cruz M, Garcia H, de Bittencourt PR, Trelles L, Arriagada C, Lorenzana P, Nash TE, Spina-Franca A, 2000. A proposal to declare neurocysticercosis an international reportable disease. Bull World Health Organ 78 : 399–406. [Google Scholar]
  3. Montano SM, Villaran MV, Ylquimiche L, Figueroa JJ, Rodriguez S, Bautista CT, Gonzalez AE, Tsang VC, Gilman RH, Garcia HH; Cysticercosis Working Group in Peru, 2005. Neurocysticercosis: association between seizures, serology, and brain CT in rural Peru. Neurology 65 : 229–233. [Google Scholar]
  4. Del Brutto OH, Santibanez R, Idrovo L, Rodriguez S, Diaz-Calderon E, Navas C, Gilman RH, Cuesta F, Mosquera A, Gonzalez AE, Tsang VC, Garcia HH, 2005. Epilepsy and neurocysticercosis in Atahualpa: a door-to-door survey in rural coastal Ecuador. Epilepsia 46 : 583–587. [Google Scholar]
  5. Medina MT, Duron RM, Martinez L, Osorio JR, Estrada AL, Zuniga C, Cartagena D, Collins JS, Holden KR, 2005. Prevalence, incidence, and etiology of epilepsies in rural Honduras: the Salama Study. Epilepsia 46 : 124–131. [Google Scholar]
  6. Nicoletti A, Bartoloni A, Sofia V, Bartalesi F, Chavez JR, Osinaga R, Paradisi F, Dumas JL, Tsang VC, Reggio A, Hall AJ, 2005. Epilepsy and neurocysticercosis in rural Bolivia: a population-based survey. Epilepsia 46 : 1127–1132. [Google Scholar]
  7. The Cysticercosis Working Group in Peru, 1993. The marketing of cysticercotic pigs in the Sierra of Peru. Bull World Health Organ 71 : 223–228. [Google Scholar]
  8. International Task Force for Disease Eradication, 1993. Recommendations of the International Task Force for Disease Eradication. MMWR Morb Mortal Wkly Rep 42 : 1–38. [Google Scholar]
  9. Maguire JH, 2004. Tapeworms and seizures—treatment and prevention. N Engl J Med 350 : 215–217. [Google Scholar]
  10. Gilman RH, Garcia HH, Gonzalez AE, Dunleavy M, Verastegui M, Evans C, and The Cysticercosis Working Group of Peru, Short cuts to development: methods to control the transmission of cysticercosis in developig countries. In: Garcia HH, Martinez SM, eds. Taenia solium Taeniasis/Cysticercosis. Lima, Peru: Ed. Universo; 1999:313–326.
  11. Schantz PM, Cruz M, Sarti E, Pawlowski Z, 1993. Potential eradicability of taeniasis and cysticercosis. Bull Pan Am Health Organ 27 : 397–403. [Google Scholar]
  12. Gemmell MA, 1987. A critical approach to the concepts of control and eradication of echinococcosis/hydatidosis and taeniasis/cysticercosis. Int J Parasitol 17 : 465–472. [Google Scholar]
  13. Pawlowski Z, Allan J, Sarti E, 2005. Control of Taenia solium taeniasis/cysticercosis: from research towards implementation. Int J Parasitol. 35:1221–1232 [Google Scholar]
  14. Cruz M, Davis A, Dixon H, Pawlowski ZS, Proano J, 1989. Operational studies on the control of Taenia solium taeniasis/cysticercosis in Ecuador. Bull World Health Organ 67 : 401–407. [Google Scholar]
  15. Diaz Camacho SP, Candil Ruiz A, Suate Peraza V, Zazueta Ramos ML, Felix Medina M, Lozano R, Willms K, 1991. Epidemiologic study and control of Taenia solium infections with praziquantel in a rural village of Mexico. Am J Trop Med Hyg 45 : 522–531. [Google Scholar]
  16. Keilbach NM, de Aluja AS, Sarti-Gutierrez E, 1989. A programme to control taeniasis-cysticercosis (T. solium): experiences in a Mexican village. Acta Leiden 57 : 181–189. [Google Scholar]
  17. Sarti E, Schantz PM, Avila G, Ambrosio J, Medina-Santillan R, Flisser A, 2000. Mass treatment against human taeniasis for the control of cysticercosis: a population-based intervention study. Trans R Soc Trop Med Hyg 94 : 85–89. [Google Scholar]
  18. Allan JC, Velasquez-Tohom M, Fletes C, Torres-Alvarez R, Lopez-Virula G, Yurrita P, Soto de Alfaro H, Rivera A, Garcia-Noval J, 1997. Mass chemotherapy for intestinal Taenia solium infection: effect on prevalence in humans and pigs. Trans R Soc Trop Med Hyg 91 : 595–598. [Google Scholar]
  19. Huerta M, de Aluja AS, Fragoso G, Toledo A, Villalobos N, Hernandez M, Gevorkian G, Acero G, Diaz A, Alvarez I, Avila R, Beltran C, Garcia G, Martinez JJ, Larralde C, Sciutto E, 2001. Synthetic peptide vaccine against Taenia solium pig cysticercosis: successful vaccination in a controlled field trial in rural Mexico. Vaccine 20 : 262–266. [Google Scholar]
  20. Flisser A, Gauci CG, Zoli A, Martinez-Ocana J, Garza-Rodriguez A, Dominguez-Alpizar JL, Maravilla P, Rodriguez- Canul R, Avila G, Aguilar-Vega L, Kyngdon C, Geerts S, Lightowlers MW, 2004. Induction of protection against porcine cysticercosis by vaccination with recombinant oncosphere antigens. Infect Immun 72 : 5292–5297. [Google Scholar]
  21. Molinari JL, Soto R, Tato P, Rodriguez D, Retana A, Sepulveda J, Palet A, 1993. Immunization against porcine cysticercosis in an endemic area in Mexico: a field and laboratory study. Am J Trop Med Hyg 49 : 502–512. [Google Scholar]
  22. Molinari JL, Rodriguez D, Tato P, Soto R, Arechavaleta F, Solano S, 1997. Field trial for reducing porcine Taenia solium cysticercosis in Mexico by systematic vaccination of pigs. Vet Parasitol 69 : 55–63. [Google Scholar]
  23. Sarti E, Flisser A, Schantz PM, Gleizer M, Loya M, Plancarte A, Avila G, Allan J, Craig P, Bronfman M, Wijeyaratne P, 1997. Development and evaluation of a health education intervention against Taenia solium in a rural community in Mexico. Am J Trop Med Hyg 56 : 127–132. [Google Scholar]
  24. Gonzalez AE, Garcia HH, Gilman RH, Tsang VCW, The Cysticercosis Working Group in Peru., 2003. Control of Taenia solium. Acta Tropica 87 : 103–109. [Google Scholar]
  25. Gonzales AE, Garcia HH, Gilman RH, Gavidia CM, Tsang VC, Bernal T, Falcon N, Romero M, Lopez-Urbina MT, 1996. Effective, single-dose treatment or porcine cysticercosis with oxfendazole. Am J Trop Med Hyg 54 : 391–394. [Google Scholar]
  26. Tsang VC, Brand JA, Boyer AE, 1989. An enzyme-linked immunoelectrotransfer blot assay and glycoprotein antigens for diagnosing human cysticercosis (Taenia solium). J Infect Dis 159 : 50–59. [Google Scholar]
  27. Pawlowski ZS, Large-scale use of chemotherapy of taeniasis as a control measure for Taenia solium infections. In: Geerts S, Kumar Y, Brandt J, eds. Helminth Zoonoses. Dordecht, Germany: M. Nijhoff; 1987:100–105.
  28. Gardner MJ, Altman DG, 1986. Confidence intervals rather than P values: estimation rather than hypothesis testing. Br Med J 292 : 746–750. [Google Scholar]
  29. Liang K, Zeger S, 1986. Longitudinal data analysis using general linear models. Bioetrica 73 : 13–22. [Google Scholar]
  30. Garcia HH, Gilman RH, Gonzalez AE, Verastegui M, Rodriguez S, Gavidia C, Tsang VC, Falcon N, Lescano AG, Moulton LH, Bernal T, Tovar M; Cysticercosis Working Group in Peru, 2003. Hyperendemic human and porcine Taenia solium infection in Peru. Am J Trop Med Hyg 68 : 268–275. [Google Scholar]
  31. Gemmell M, Matyas Z, Pawlowsky Z, Soulsby EJL, Guidelines for Surveillance and Control of Taeniasis/Cysticercosis. Vol. 83.49. Geneva, Switzerland: World Health Organization; 1983.
  32. Garcia HH, Gonzalez AE, Gilman RH, for the Cysticercosis Working Group in Peru, 2003. Diagnosis, treatment and control of Taenia solium cysticercosis. Curr Opin Infect Dis 16: 411–419. [Google Scholar]
  33. Anderson RM, May RM, 1982. Population dynamics of human helminth infections: control by chemotherapy. Nature 297 : 557–563. [Google Scholar]
  34. Gonzalez AE, 1997. Evaluation of a control programme for Taenia solium targeting human and porcine health. Veterinary Epidemiology. Reading, UK: University of Reading.
  35. Gonzalez AE, Falcon N, Gavidia C, Garcia HH, Tsang VC, Bernal T, Romero M, Gilman RH, 1997. Treatment of porcine cysticercosis with oxfendazole: a dose-response trial. Vet Rec 141 : 420–422. [Google Scholar]
  36. Gonzalez AE, Falcon N, Gavidia C, Garcia HH, Tsang VC, Bernal T, Romero M, Gilman RH, 1998. Time-response curve of oxfendazole in the treatment of swine cysticercosis. Am J Trop Med Hyg 59 : 832–836. [Google Scholar]
  37. Gonzalez AE, Verastegui M, Noh JC, Gavidia C, Falcon N, Bernal T, Garcia HH, Tsang VC, Gilman RH, Wilkins PP, 1999. Persistence of passively transferred antibodies in porcine Taenia solium cysticercosis. Cysticercosis Working Group in Peru. Vet Parasitol 86 : 113–118. [Google Scholar]

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  • Received : 13 Oct 2005
  • Accepted : 06 Dec 2005

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