1921
Volume 74, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Contact with a caterpillar of the genus can result in a hemorrhagic syndrome. venom activates prothrombin and factor X and promotes fibrinogenolytic activity. Although crude bristle extract can induce hemolytic activity in human and rat erythrocytes, there have been no reports of hemolysis in the cases of human contact. We report a confirmed human case of venom-induced hemolysis.

Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2006.74.807
2006-05-01
2017-07-28
Loading full text...

Full text loading...

/deliver/fulltext/14761645/74/5/0740807.html?itemId=/content/journals/10.4269/ajtmh.2006.74.807&mimeType=html&fmt=ahah

References

  1. Arocha-Piñango CL, 1967. Fibrinolysis caused by contact with caterpillars: preliminary communication. Acta Cient Venez 18 : 136–139.
  2. Kelen EM, Picarelli ZP, Duarte AC, 1995. Hemorrhagic syndrome induced by contact with caterpillars of the genus Lonomia (Saturniidae, Hemileucinae). J Toxicol Toxin Rev 14 : 283–308.
  3. Duarte AC, Caovilla J, Lorini I, Lorini D, Montovani G, Sumida J, Marifre PC, Silveira R, 1990. Insuficiência renal aguda por acidentes com lagartas. J Bras Nefrol 12 : 184–186.
  4. Burdmann EA, Antunes I, Saldanha LB, Abdulkader RC, 1996. Severe acute renal failure induced by the venom of Lonomia caterpillars. Clin Nephrol 46 : 337–339.
  5. Donato JL, Moreno RA, Hyslop S, Duarte A, Antunes E, Le Bonniec BF, Rendu F, Nucci G, 1998. Lonomia obliqua caterpillar spicules trigger human blood coagulation via activation of factor X and prothrombin. Thromb Haemost 79 : 539–542.
  6. Veiga AB, Pinto AFM, Guimarães JA, 2003. Fibrinogenolytic and procoagulant activities in the hemorrhagic syndrome caused by Lonomia obliqua caterpillars. Thromb Res 111 : 95–101.
  7. Pinto AF, Dobrovolski R, Veiga AB, Guimarães JA, 2004. Lonofibrase, a novel α-fibrinogenase from Lonomia obliqua caterpillars. Thromb Res 113 : 147–154.
  8. Seibert CS, Shinohara EM, Sano-Martins IS, 2003. In vitro hemolytic activity of Lonomia obliqua caterpillar bristle extract on human and Wistar rat erythrocytes. Toxicon 41 : 831–839.
  9. Fraiha Neto H, Costa Jr DC, de Leão RN, Ballarini AJ, 1992. Acidentes hemorrágicos por larvas de Lonomia. Schvartsman S, ed. Plantas Venenosas e Animais Peçonhentos. Sao Paulo: Sarvier, 241–244.
  10. Fan HW, Duarte AC, 2003. Acidentes por Lonomia. Cardoso JL, França FO, Fan HW, Malaque CM, Haddad V Jr., eds. Animais Peçonhentos no Brasil. Biologia, Clínica e Terapêutica dos Acidentes. Sao Paulo: Sarvier/FAPESP, 224–232.
  11. Zannin M, Lourenço DM, Motta G, Dalla Costa LR, Grando M, Gamborgi GP, Noguti MA, Chudzinski-Tavassi AM, 2003. Blood coagulation and fibrinolytic factors in 105 patients with hemorrhagic syndrome caused by accidental contact with Lonomia obliqua caterpillar in Santa Catarina, southern Brazil. Thromb Haemost 89 : 355–364.
  12. Bick RL, Baker WF, 1992. Disseminated intravascular coagulation syndromes. Hematol Pathol 6 : 1–24.
  13. Rakic S, 1999. New findings on the physiopathology of acute hemolytic transfusion reaction. Med Pregl 52 : 19–24.
  14. Brady HR, Brenner BM, Lieberthal W, 1996. Acute renal failure. Brenner BM, ed. The Kidney. Fifth edition. Philadelphia: W. B. Saunders Company, 1200–1252.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2006.74.807
Loading
/content/journals/10.4269/ajtmh.2006.74.807
Loading

Data & Media loading...

  • Received : 06 Sep 2005
  • Accepted : 15 Dec 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error