1921
Volume 74, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Protective immunity against is partially mediated through binding of malaria-specific IgG antibodies to Fcγ receptors. Polymorphic variability in Fcγ RIIa (H/R-131) is associated with differential binding of IgG subtypes and malaria disease outcomes. However, the role of Fcγ RIIa-131 variability in conditioning susceptibility to severe malarial anemia, the primary manifestation of severe malaria in holoendemic transmission areas, is largely undefined. Thus, Fcγ RIIa-H131R polymorphism was investigated in 493 children who came to a hospital with acute malaria. Variation in Fcγ RIIa-131 was not significantly associated with severe malarial anemia (hemoglobin [Hb] < 6.0 g/dL) or malaria anemia (Hb < 8.0 g/dL). However, relative to the heterozygous genotype, homozygotes for the R131 alleles were protected against high-density parasitemia (≥ 10,000 parasites/μL; odds ratio [OR] = 0.58, 95% confidence interval [CI] = 0.37–0.92, = 0.02), while homozygotes for the H131 alleles were mildly protective (OR = 0.71, 95% CI = 0.45–1.13, = 0.14). Additional multivariate analyses showed that infection with human immunodeficiency virus type 1 did not influence the associations between FcγRIIa-H131R polymorphism and malaria disease outcomes. Genotypic results presented here parallel data illustrating that parasite density is unrelated to the severity of anemia in children with acute malaria. Thus, although homozygosity for the R131 allele protects against high-density parasitemia, FcγRIIa-131 polymorphism does not protect against malaria anemia.

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2006-04-01
2017-09-22
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References

  1. Breman JG, Egan A, Keusch GT, 2001. The intolerable burden of malaria: a new look at the numbers. Am J Trop Med Hyg 64 (Suppl): iv–vii.
  2. Sabchareon A, Burnouf T, Ouattara D, Attanath P, Bouharoun-Tayoun H, Chantavanich P, Foucault C, Chongsuphajaisiddhi T, Druilhe P, 1991. Parasitologic and clinical human response to immunoglobulin administration in falciparum malaria. Am J Trop Med Hyg 45 : 297–308.
  3. Stein MP, Edberg JC, Kimberly RP, Mangan EK, Bharadwaj D, Mold C, Du Clos TW, 2000. C-reactive protein binding to FcgammaRIIa on human monocytes and neutrophils is allele-specific. J Clin Invest 105 : 369–376.
  4. Bouharoun-Tayoun H, Oeuvray C, Lunel F, Druilhe P, 1995. Mechanisms underlying the monocyte-mediated antibody-dependent killing of Plasmodium falciparum asexual blood stages. J Exp Med 182 : 409–418.
  5. Shi YP, Nahlen BL, Kariuki S, Urdahl KB, McElroy PD, Roberts JM, Lal AA, 2001. Fcgamma receptor IIa (CD32) polymorphism is associated with protection of infants against high-density Plasmodium falciparum infection. VII. Asembo Bay Cohort Project. J Infect Dis 184 : 107–111.
  6. Warmerdam PA, van de Winkel JG, Vlug A, Westerdaal NA, Capel PJ, 1991. A single amino acid in the second Ig-like domain of the human Fc gamma receptor II is critical for human IgG2 binding. J Immunol 147 : 1338–1343.
  7. Cooke GS, Aucan C, Walley AJ, Segal S, Greenwood BM, Kwiatkowski DP, Hill AV, 2003. Association of Fcgamma receptor IIa (CD32) polymorphism with severe malaria in west Africa. Am J Trop Med Hyg 69 : 565–568.
  8. Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, Tokunaga K, 2002. Fcgamma receptor IIA and IIIB polymorphisms are associated with susceptibility to cerebral malaria. Parasitol Int 51 : 361–366.
  9. Bloland PB, Ruebush TK, McCormick JB, Ayisi J, Boriga DA, Oloo AJ, Beach R, Hawley W, Lal A, Nahlen B, Udhayakumar V, Campbell CC, 1999. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission I. Description of study site, general methodology, and study population. Am J Trop Med Hyg 60 (Suppl): 635–640.
  10. Bloland PB, Boriga DA, Ruebush TK, McCormick JB, Roberts JM, Oloo AJ, Hawley W, Lal A, Nahlen B, Campbell CC, 1999. Longitudinal cohort study of the epidemiology of malaria infections in an area of intense malaria transmission II. Descriptive epidemiology of malaria infection and disease among children. Am J Trop Med Hyg 60 (Suppl): 641–648.
  11. McElroy PD, Lal AA, Hawley WA, Bloland PB, Kuile FO, Oloo AJ, Harlow SD, Lin X, Nahlen BL, 1999. Analysis of repeated hemoglobin measures in full-term, normal birth weight Kenyan children between birth and four years of age. III. The Asemobo Bay Cohort Project. Am J Trop Med Hyg 61 : 932–940.
  12. Hunt JC, Brennan CA, Golden AM, Yamaguchi J, Lund JK, Vallari AS, Hickman RK, Zekeng L, Gurtler LG, Hampl H, Kaptue L, Devare SG, 1997. Molecular analyses of HIV-1 group O and HIV-2 variants from Africa. Leukemia 11 (Suppl 3): 138–141.
  13. Yang C, Pieniazek D, Owen SM, Fridlund C, Nkengasong J, Mastro TD, Rayfield MA, Downing R, Biryawaho B, Tanuri A, Zekeng L, van der Groen G, Gao F, Lal RB, 1999. Detection of phylogenetically diverse human immunodeficiency virus type 1 groups M and O from plasma by using highly sensitive and specific generic primers. J Clin Microbiol 37 : 2581–2586.
  14. Vignoli C, de Lamballerie X, Zandotti C, Tamalet C, de Micco P, 1995. Advantage of a rapid extraction method of HIV1 DNA suitable for polymerase chain reaction. Res Virol 146 : 159–162.
  15. Jiang XM, Arepally G, Poncz M, McKenzie SE, 1996. Rapid detection of the Fc gamma RIIA-H/R 131 ligand-binding polymorphism using an allele-specific restriction enzyme digestion (ASRED). J Immunol Methods 199 : 55–59.
  16. Abdalla S, 1990. Hematopoiesis in human malaria. Blood Cells 16 : 401–416.
  17. World Health Organization, 2000. WHO Expert Committee on Malaria. World Health Organ Tech Rep Ser 892 : 1–74.
  18. Otieno RO, Ouma C, Ong’echa JM, Keller CC, Were T, Waindi EN, Michaels MG, Day RD, Vulule JM, Perkins DJ, 2006. Increased severe malarial anemia in HIV-1-exposed and HIV-1-positive infants and children. AIDS 20 : 275–280.
  19. Brouwer KC, Lal RB, Mirel LB, Yang C, van Eijk AM, Ayisi J, Otieno J, Nahlen BL, Steketee R, Lal AA, Shi YP, 2004. Polymorphism of Fc receptor IIa for IgG in infants is associated with susceptibility to perinatal HIV-1 infection. AIDS 18 : 1187–1194.
  20. Brouwer KC, Lal AA, Mirel LB, Otieno J, Ayisi J, Van Eijk AM, Lal RB, Steketee R, Nahlen BL, Shi YP, 2004. Polymorphism of Fc receptor IIa for immunoglobulin G is associated with placental malaria in HIV-1-positive women in western Kenya. J Infect Dis 190 : 1192–1198.
  21. Groux H, Gysin J, 1990. Opsonization as an effector mechanism in human protection against asexual blood stages of Plasmodium falciparum: functional role of IgG subclasses. Res Immunol 141 : 529–542.
  22. Druilhe P, Perignon JL, 1994. Mechanisms of defense against P. falciparum asexual blood stages in humans. Immunol Lett 41 : 115–120.
  23. Yone CL, Kremsner PG, Luty AJ, 2005. Immunoglobulin G isotype responses to erythrocyte surface-expressed variant antigens of Plasmodium falciparum predict protection from malaria in African children. Infect Immun 73 : 2281–2287.
  24. Bouharoun-Tayoun H, Druilhe P, 1992. Plasmodium falciparum malaria: evidence for an isotype imbalance which may be responsible for delayed acquisition of protective immunity. Infect Immun 60 : 1473–1481.
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  • Received : 12 Aug 2005
  • Accepted : 27 Sep 2005

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