Volume 74, Issue 4
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The human body louse is currently recognized as a vector of , , and . Previous studies have reported the isolation of from the body lice of homeless patients. To study how the body louse acquires , we infected a rabbit by infusing 2 × 10 colony-forming units of the louse strain of . Two hundred body lice were infected by feeding on the bacteremic rabbit and compared with 200 uninfected lice and two groups of 200 lice feeding on rabbits infected either with another strain of or . Each louse group received maintenance feedings once a day on another seronegative rabbit. Body lice that fed on rabbits infused with each species demonstrated a generalized infection. The body lice did not transmit their infection to the nurse rabbit by bite while feeding or to their progeny (eggs and larvae). The lice excreted living species within their feces. Only the louse strain of was pathogenic for the body louse. An increased mortality rate was observed between the second and third days post-infection; however, they remained infected for their lifespan.


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  1. Raoult D, Roux V, 1999. The body louse as a vector of reemerging human diseases. Clin Infect Dis 29 : 888–911.
  2. La Scola B, Fournier PE, Brouqui P, Raoult D, 2001. Detection and culture of Bartonella quintana, Serratia marcescens and Acinetobacter spp. from decontaminated human body lice. J Clin Microbiol 39 : 1707–1709.
  3. La Scola B, Raoult D, 2004. Acinetobacter baumannii in human body louse. Emerg Infect Dis 10 : 1671–1673.
  4. Seifert H, 1995. Acinetobacter species as a cause of catheter-related infections. Zentralbl Bakteriol 283 : 161–168.
  5. Berlau J, Aucken HM, Houang E, Pitt TL, 1999. Isolation of Acinetobacter spp. including A. baumannii from vegetables: implications for hospital-acquired infections. J Hosp Infect 42 : 201–204.
  6. Berlau J, Aucken H, Malnick H, Pitt T, 1999. Distribution of Acinetobacter species on skin of healthy humans. Eur J Clin Microbiol Infect Dis 18 : 179–183.
  7. Cisneros JM, Rodriguez-Bano J, 2002. Nosocomial bacteremia due to Acinetobacter baumannii: epidemiology, clinical features and treatment. Clin Microbiol Infect 8 : 687–693.
  8. Joly-Guillou ML, 1998. Bacteria of the Acinetobacter genus. Pathol Biol (Paris) 46 : 245–252.
  9. Boukadida J, 2000. Ecological aspects and prophylaxis of Acinetobacter baumannii nosocomial infection. Tunis Med 78 : 480–483.
  10. Chiang WC, Su CP, Hsu CY, Chen SY, Chen YC, Chang SC, Hsueh PR, 2003. Community-acquired bacteremic cellulitis caused by Acinetobacter baumannii. J Formos Med Assoc 102 : 650–652.
  11. Okpara AU, Maswoswe JJ, 1994. Emergence of multidrug-resistant isolates of Acinetobacter baumannii. Am J Hosp Pharm 51 : 2671–2675.
  12. Chen MZ, Hsueh PR, Lee LN, Yu CJ, Yang PC, Luh KT, 2001. Severe community-acquired pneumonia due to Acinetobacter baumannii. Chest 120 : 1072–1077.
  13. Yang CH, Chen KJ, Wang CK, 1997. Community-acquired Acinetobacter pneumonia: a case report. J Infect 35 : 316–318.
  14. Chang WN, Lu CH, Huang CR, Chuang YC, 2000. Community-acquired Acinetobacter meningitis in adults. Infection 28 : 395–397.
  15. Fournier PE, Ndihokubwayo JB, Guidran J, Kelly PJ, Raoult D, 2002. Human pathogens in body and head lice. Emerg Infect Dis 8 : 1515–1518.
  16. Fournier PE, Minnick MF, Lepidi H, Salvo E, Raoult D, 2001. Experimental model of human body louse infection using green fluorescent protein-expressing Bartonella quintana. Infect Immun 69 : 1876–1879.
  17. Houhamdi L, Fournier PE, Fang R, Lepidi H, Raoult D, 2002. An experimental model of human body louse infection with Rickettsia prowazekii. J Infect Dis 186 : 1639–1646.
  18. Maunder JW, 1983. The appreciation of lice. Proc R Inst Great Britain 55 : 1–31.
  19. Greer CE, Peterson SL, Kiviat NB, Manos MM, 1991. PCR amplification from paraffin-embedded tissues. Effects of fixative and fixation time. Am J Clin Pathol 95 : 117–124.
  20. Fenollar F, Raoult D, 1999. Diagnosis of rickettsial diseases using samples dried on blotting paper. Clin Diagn Lab Immunol 6 : 483–488.
  21. Zhu Y, Fournier PE, Rydkina E, Raoult D, 2003. The geographical segregation of human lice preceded that of Pediculus humanus capitis and Pediculus humanus humanus. C R Biol 326 : 565–574.
  22. DeSalle R, Gatesy J, Wheeler W, Grimaldi D, 1992. DNA sequences from a fossil termite in Oligo-Miocene amber and their phylogenetic implications. Science 257 : 1933–1936.
  23. Menotti J, Cassinat B, Porcher R, Sarfati C, Derouin F, Molina JM, 2003. Development of a real-time polymerase-chain-reaction assay for quantitative detection of Enterocytozoon bieneusi DNA in stool specimens from immunocompromised patients with intestinal microsporidiosis. J Infect Dis 187 : 1469–1474.
  24. Wolbach SB, Todd JL, Palfrey FW, 1922. Rickettsia prowazeki in lice. Wolbach S, Todd J, Palfrey F, eds. The Etiology and Pathology of Typhus. Cambridge, MA: Harvard University Press, 132–142.
  25. Jawad A, Seifert H, Snelling AM, Heritage J, Hawkey PM, 1998. Survival of Acinetobacter baumannii on dry surfaces: comparison of outbreak and sporadic isolates. J Clin Microbiol 36 : 1938–1941.
  26. Rathinavelu S, Zavros Y, Merchant JL, 2003. Acinetobacter lwoffii infection and gastritis. Microbes Infect 5 : 651–657.
  27. Nicolle C, Comte C, Conseil E, 1999. Transmission expérimentale du typhus exanthématique par le pou du corps. Acad Sci (Paris) 146 : 486–489.
  28. Ito S, Vinson JW, 1965. Fine structure of Rickettsia quintana cultivated in vitro and in the louse. J Bacteriol 89 : 481–495.
  29. Uete T, Matsuo K, 1984. Clinical laboratory approach for estimating effective administration of dosage of cefmenoxime. Observation on the MICS and cefmenoxime disc susceptibility test. Jpn J Antibiot 37 : 791–801.
  30. Joly-Guillou ML, Wolff M, Pocidalo JJ, Walker F, Carbon C, 1997. Use of a new mouse model of Acinetobacter baumannii pneumonia to evaluate the postantibiotic effect of imipenem. Antimicrob Agents Chemother 41 : 345–351.
  31. Jang TN, Kuo BI, Shen SH, Fung CP, Lee SH, Yang TL, Huang CS, 1999. Nosocomial gram-negative bacteremia in critically ill patients: epidemiologic characteristics and prognostic factors in 147 episodes. J Formos Med Assoc 98 : 465–473.
  32. Cisneros JM, Reyes MJ, Pachon J, Becerril B, Caballero FJ, Garcia-Garmendia JL, Ortiz C, Cobacho AR, 1996. Bacteremia due to Acinetobacter baumannii: epidemiology, clinical findings, and prognostic features. Clin Infect Dis 22 : 1026–1032.
  33. Lai SW, Ng KC, Yu WL, Liu CS, Lai MM, Lin CC, 1999. Acinetobacter baumannii bloodstream infection: clinical features and antimicrobial susceptibilities of isolates. Kaohsiung J Med Sci 15 : 406–413.
  34. Gospodarek E, Grzanka A, Dudziak Z, Domaniewski J, 1998. Electron-microscopic observation of adherence of Acinetobacter baumannii to red blood cells. Acta Microbiol Pol 47 : 213–217.
  35. Fleischer M, Przondo-Mordarska A, 1993. Hemolytic properties of bacteria from the genus Acinetobacter. Med Dosw Mikrobiol 45 : 311–315.
  36. Garcia A, Salgado F, Solar H, Gonzalez CL, Zemelman R, Onate A, 1999. Some immunological properties of lipopolysaccharide from Acinetobacter baumannii. J Med Microbiol 48 : 479–483.
  37. Siau H, Yuen KY, Ho PL, Wong SS, Woo PC, 1999. Acinetobacter bacteremia in Hong Kong: prospective study and review. Clin Infect Dis 28 : 26–30.
  38. Daniel M, Sramova H, Absolonova V, Dedicova D, Lhotova H, Maskova L, Petras P, 1992. Arthropods in a hospital and their potential significance in the epidemiology of hospital infections. Folia Parasitol (Praha) 39 : 159–170.
  39. Lysyk TJ, Kalischuk-Tymensen L, Selinger LB, Lancaster RC, Wever L, Cheng KJ, 1999. Rearing stable fly larvae (Diptera: Muscidae) on an egg yolk medium. J Med Entomol 36 : 382–388.
  40. Murrell A, Dobsen SJ, Yang X, Lacey E, Barker SC, 2003. A survey of bacterial diversity in ticks, lice and fleas from Australia. Parasitol Res 89 : 326–334.
  41. Oliveira SM, Moraes BA, Goncalves CA, Giordano-Dias CM, D’Almeida JM, Asensi MD, Mello RP, Brazil RP, 2000. Rev Soc Bras Med Trop 33 : 319–322.
  42. Sramova H, Daniel M, Absolonova V, Dedicova D, Jedlickova Z, Lhotova H, Petras P, Subertova V, 1992. Epidemiological role of arthropods detectable in health facilities. J Hosp Infect 20 : 281–292.

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  • Received : 13 Jul 2004
  • Accepted : 19 Nov 2004

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