1921
Volume 74, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Transmission of malaria is initiated by sexual stages in the mosquito. Anti-Pfs48/45 and anti-Pfs230 sexual stage antibodies that are ingested together with parasites can reduce parasite development and subsequently malaria transmission. Acquisition of sexual stage immunity was studied in a cohort of 102 non-immune Javanese individuals migrating to hyperendemic Papua Indonesia. Seroprevalence of antibodies against Pfs48/45 and Pfs230 and functional transmission-reducing activity (TRA) were measured upon arrival and at 6, 12, and 24 months. Asexual parasitemia and gametocytemia were assessed every two weeks. The TRA and seroreactivity increased with the number of infections. The longitudinally sustained association between TRA and antibodies against Pfs48/45 (odds ratio [OR] = 3.74, 95% confidence interval [CI] = 1.51–9.29) and Pfs230 (OR = 3.72, 95% CI = 1.36–10.17) suggests that functional transmission reducing immunity is acquired after limited exposure to infection.

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2006-03-01
2017-09-21
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References

  1. Kaslow DC, 1993. Transmission-blocking immunity against malaria and other vector-borne diseases. Curr Opin Immunol 5 : 557–565.
  2. Mulder B, Lensen T, Tchuinkam T, Roeffen W, Verhave JP, Boudin C, Sauerwein R, 1999. Plasmodium falciparum: membrane feeding assays and competition ELISAs for the measurement of transmission reduction in sera from Cameroon. Exp Parasitol 92 : 81–86.
  3. Ponnudurai T, van Gemert GJ, Bensink T, Lensen AH, Meuwissen JH, 1987. Transmission blockade of Plasmodium falciparum: its variability with gametocyte numbers and concentration of antibody. Trans R Soc Trop Med Hyg 81 : 491–493.
  4. Vermeulen AN, Ponnudurai T, Beckers PJ, Verhave JP, Smits MA, Meuwissen JH, 1985. Sequential expression of antigens on sexual stages of Plasmodium falciparum accessible to transmission-blocking antibodies in the mosquito. J Exp Med 162 : 1460–1476.
  5. Drakeley CJ, Mulder L, Tchuinkam T, Gupta S, Sauerwein R, Targett GA, 1998. Transmission-blocking effects of sera from malaria-exposed individuals on Plasmodium falciparum isolates from gametocyte carriers. Parasitology 116 : 417–423.
  6. Graves PM, Doubrovsky A, Sattabongkot J, Battistutta D, 1992. Human antibody responses to epitopes on the Plasmodium falciparum gametocyte antigen PFS 48/45 and their relationship to infectivity of gametocyte carriers. Am J Trop Med Hyg 46 : 711–719.
  7. Healer J, McGuinness D, Hopcroft P, Haley S, Carter R, Riley E, 1997. Complement-mediated lysis of Plasmodium falciparum gametes by malaria-immune human sera is associated with antibodies to the gamete surface antigen Pfs230. Infect Immun 65 : 3017–3023.
  8. Healer J, McGuinness D, Carter R, Riley E, 1999. Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230. Parasitology 119 : 425–433.
  9. Carter R, Mendis K, 1992. Transmission immunity in malaria: reflections on the underlying immune mechanisms during natural infections and following artificial immunization. Mem Inst Oswaldo Cruz 87 : 169–173.
  10. Roeffen W, Mulder B, Teelen K, Bolmer M, Eling W, Targett GA, Beckers PJ, Sauerwein R, 1996. Association between anti-Pfs48/45 reactivity and P. falciparum transmission-blocking activity in sera from Cameroon. Parasite Immunol 18 : 103–109.
  11. Andersen E, Jones TR, Purnomo , Masbar S, Wiady I, Tirtolusumo S, Bangs MJ, Charoenvit Y, Gunawan S, Hoffman SL, 1997. Assessment of age-dependent immunity to malaria in transmigrants. Am J Trop Med Hyg 56 : 647–649.
  12. Baird JK, Krisin A, Barcus MJ, Elyazar IR, Bangs MJ, Maguire JD, Fryauff DJ, Richie TL, Sekartuti , Kalalo W, 2003. Onset of clinical immunity to Plasmodium falciparum among Javanese migrants to Indonesian Papua. Ann Trop Med Parasitol 97 : 557–564.
  13. Baird JK, Jones TR, Danudirgo EW, Annis BA, Bangs MJ, Basri H, Purnomo , Masbar S, 1991. Age-dependent acquired protection against Plasmodium falciparum in people having two years exposure to hyperendemic malaria. Am J Trop Med Hyg 45 : 65–76.
  14. Barcus MJ, Krisin , Elyazar IR, Marwoto H, Richie TL, Basri H, Wiady I, Fryauff DJ, Maguire JD, Bangs MJ, Barid JK, 2003. Primary infection by Plasmodium falciparum or P. vivax in a cohort of Javanese migrants to Indonesian Papua. Ann Trop Med Parasitol 97 : 565–574.
  15. Hudson Keenihan SN, Ratiwayanto S, Soebianto S, Krisin , Marwoto H, Krishnegowda G, Gowda DC, Bangs MJ, Fryauff DJ, Richie TL, Kumar S, Baird JK, 2003. Age-dependent impairment of IgG responses to glycosylphosphatidylinositol with equal exposure to Plasmodium falciparum among Javanese migrants to Papua, Indonesia. Am J Trop Med Hyg 69 : 36–41.
  16. Krisin , Basri H, Fryauff DJ, Barcus MJ, Bangs MJ, Ayomi E, Marwoto H, Elyazar IR, Richie TL, Baird JK, 2003. Malaria in a cohort of Javanese migrants to Indonesian Papua. Ann Trop Med Parasitol 97 : 543–556.
  17. Hogh B, Petersen E, Dziegiel M, David K, Hanson A, Borre M, Holm A, Vuust J, Jepsen S, 1992. Antibodies to a recombinant glutamate-rich Plasmodium falciparum protein: evidence for protection of individuals living in a holoendemic area of Liberia. Am J Trop Med Hyg 46 : 307–313.
  18. Dodoo D, Theisen M, Kurtzhals JA, Akanmori BD, Koram KA, Jepsen S, Nkrumah FK, Theander TG, Hviid L, 2000. Naturally acquired antibodies to the glutamate-rich protein are associated with protection against Plasmodium falciparum malaria. J Infect Dis 181 : 1202–1205.
  19. Soe S, Theisen M, Roussilhon C, Aye K-S, Druilhe P, 2004. Association between protection against clinical malaria and antibodies to merozoite surface antigens in an area of hyperendemicity in Myanmar: complementarity between responses to merozoite surface protein 3 and the 220-kilodalton glutamate-rich protein. Infect Immun 72 : 247–252.
  20. Theisen M, Dodoo D, Toure-Balde A, Soe S, Corradin G, Koram KK, Kurtzhals JA, Hviid L, Theander T, Akanmori B, Ndiaye M, Druilhe P, 2001. Selection of glutamate-rich protein long synthetic peptides for vaccine development: antigenicity and relationship with clinical protection and immunogenicity. Infect Immun 69 : 5223–5229.
  21. Barcus MJ, Laihad F, Sururi M, Sismadi P, Marwoto H, Bangs MJ, Baird JK, 2002. Epidemic malaria in the Menoreh Hills of Central Java. Am J Trop Med Hyg 66 : 287–292.
  22. Jones TR, Baird JK, Bangs MJ, Annis BA, Purnomo, Basri H, Gunawan S, Harjosuwarno S, McElroy PD, Hoffman SL, 1994. Malaria vaccine study site in Irian Jaya, Indonesia: Plasmodium falciparum incidence measurements and epidemiologic considerations in sample size estimation. Am J Trop Med Hyg 50 : 210–218.
  23. Ponnudurai T, Lensen AH, Leeuwenberg AD, Meuwissen JH, 1982. Cultivation of fertile Plasmodium falciparum gametocytes in semi-automated systems. 1. Static cultures. Trans R Soc Trop Med Hyg 76 : 812–818.
  24. Theisen M, Soe S, Oeuvray C, Thomas AW, Vuust J, Danielsen S, Jepsen S, Druilhe P, 1998. The glutamate-rich protein (GLURP) of Plasmodium falciparum is a target for antibody-dependent monocyte-mediated inhibition of parasite growth in vitro. Infect Immun 66 : 11–17.
  25. Lensen A, van Druten J, Bolmer M, van Gemert G, Eling W, Sauerwein R, 1996. Measurement by membrane feeding of reduction in Plasmodium falciparum transmission induced by endemic sera. Trans R Soc Trop Med Hyg 90 : 20–22.
  26. Ponnudurai T, Lensen AH, van Gemert GJ, Bensink MP, Bolmer M, Meuwissen JH, 1989. Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes. Parasitology 98 : 165–173.
  27. van der Kolk M, de Vlas S, Saul A, van de Vegte-Bolmer M, Eling WM, Sauerwein RW, 2004. Evaluation of the standard membrane feeding assay (SMFA) for the determination of malaria transmission reducing activity using empirical data. Parasitology 130 : 13–22.
  28. Ong CS, Zhang KY, Eida SJ, Graves PM, Dow C, Looker M, Rogers NC, Chiodini PL, Targett GA, 1990. The primary antibody response of malaria patients to Plasmodium falciparum sexual stage antigens which are potential transmission blocking vaccine candidates. Parasite Immunol 12 : 447–456.
  29. Graves PM, Doubrovsky A, Carter R, Eida S, Beckers P, 1990. High frequency of antibody response to Plasmodium falciparum gametocyte antigens during acute malaria infections in Papua New Guinea highlanders. Am J Trop Med Hyg 42 : 515–520.
  30. Mulder B, van der LW, Sauerwein R, Verhave JP, 1998. Detection of Plasmodium falciparum gametocytes with the OBC test and Giemsa-stained thick blood films for malaria transmission studies in Cameroon. Trans R Soc Trop Med Hyg 92 : 395–396.
  31. Nassir E, Abdel-Muhsin AM, Suliaman S, Kenyon F, Kheir A, Geha H, Ferguson HM, Walliker D, Babiker HA, 2005. Impact of genetic complexity on longevity and gametocytogenesis of Plasmodium falciparum during the dry and transmission-free season of eastern Sudan. Int J Parasitol 35 : 49–55.
  32. Pichon G, Awono-Ambene HP, Robert V, 2000. High heterogeneity in the number of Plasmodium falciparum gametocytes in the bloodmeal of mosquitoes fed on the same host. Parasitology 121 : 115–120.
  33. Mendis KN, Munesinghe YD, de Silva YN, Keragalla I, Carter R, 1987. Malaria transmission-blocking immunity induced by natural infections of Plasmodium vivax in humans. Infect Immun 55 : 369–372.
  34. Ramsey JM, Salinas E, Rodriguez MH, 1996. Acquired transmission-blocking immunity to Plasmodium vivax in a population of southern coastal Mexico. Am J Trop Med Hyg 54 : 458–463.
  35. Ranawaka MB, Munesinghe YD, de Silva DM, Carter R, Mendis KN, 1988. Boosting of transmission-blocking immunity during natural Plasmodium vivax infections in humans depends upon frequent reinfection. Infect Immun 56 : 1820–1824.
  36. Roeffen W, Lensen T, Mulder B, Teelen K, Sauerwein R, Eling W, Meuwissen JH, Beckers P, 1994. Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera. Mem Inst Oswaldo Cruz 89 (Suppl): 13–15.
  37. Roeffen W, Geeraedts F, Eling W, Beckers P, Wizel B, Kumar N, Lensen T, Sauerwein R, 1995. Transmission blockade of Plasmodium falciparum malaria by anti-Pfs230-specific antibodies is isotype dependent. Infect Immun 63 : 467–471.
  38. Roeffen W, Lensen T, Mulder B, Teelen K, Sauerwein R, van Druten J, Eling W, Meuwissen JH, Beckers PJ, 1995. A comparison of transmission-blocking activity with reactivity in a Plasmodium falciparum 48/45-kD molecule-specific competition enzyme-linked immunosorbent assay. Am J Trop Med Hyg 52 : 60–65.
  39. Roeffen W, Teelen K, van As J, van de Vegte-Bolmer M, Eling W, Sauerwein R, 2001. Plasmodium falciparum: production and characterization of rat monoclonal antibodies specific for the sexual-stage Pfs48/45 antigen. Exp Parasitol 97 : 45–49.
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  • Received : 09 Sep 2005
  • Accepted : 20 Oct 2005

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