1921
  1. Home
  2. The American Journal of Tropical Medicine and Hygiene
  3. Volume 74, Issue 3
  4. Article
Volume 74, Issue 3
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
Download

Abstract

A study was conducted to investigate a possible pharmacokinetic interaction between azithromycin and chloroquine. Twenty-four subjects received azithromycin, 1,000 mg a day for three days, followed by a washout period, then azithromycin, 1,000 mg plus chloroquine 600 mg base on days 1 and 2, and azithromycin, 1,000 mg plus chloroquine 300 mg base on day 3 of the final period. A second group of 16 subjects received chloroquine, 600 mg base on days 1 and 2, then 300 mg base on day 3. Blood samples were obtained serially up to 624 hours after the day 3 dose in each period. Log transformed maximum concentration and area under the curve values of azithromycin and chloroquine were compared using 90% confidence intervals calculated from appropriate analysis of variance models. Ninety percent confidence intervals for all pharmacokinetic parameters were contained within the interval 80–125%, which indicates the absence of a clinically relevant pharmacokinetic interaction.

Copyright 2006 The American Society of Tropical Medicine
Loading

Article metrics loading...

/content/journals/10.4269/ajtmh.2006.74.407
2006-03-01
2018-04-19

  • From This Site

    /content/journals/10.4269/ajtmh.2006.74.407
    dcterms_title,dcterms_subject,pub_keyword
    10
    5
Loading full text...

Full text loading...

/deliver/fulltext/14761645/74/3/0740407.html?itemId=/content/journals/10.4269/ajtmh.2006.74.407&mimeType=html&fmt=ahah

References

  1. Ohrt C, Willingmyre GD, Lee P, Knirsch C, Milhous W, 2002. Assessment of azithromycin in combination with other anti-malarial drugs against plasmodium falciparum in vitro. Antimicrob Agents Chemother 46 : 2518–2524.
  2. Dunne MW, Singh N, Shukla M, Valecha N, Bhattacharyya PC, Dev V, Patel K, Mohapatra MK, Lakhani J, Benner R, Lele C, Patki K, 2005. A multicenter study of azithromycin, alone and in combination with chloroquine, for the treatment of acute uncomplicated Plasmodium falciparum malaria in India. J Infect Dis 191 : 1582–1588.
  3. Bray PG, Boulter MK, Ritchie GY, Howells RE, Ward SA, 1994. Relationship of global chloroquine transport and reversal of resistance in Plasmodium falciparum. Mol Biochem Parasitol 63 : 87–94.
  4. Pachot JI, Botham RP, Haegele KD, Hwang K, 2003. Experimental estimation of the role of p-glycoprotein in the pharmacokinetic behaviour of telithromycin, a novel ketolide, in comparison with roxithromycin and other macrolides using the caco-2 cell model. J Pharm Pharm Sci 6 : 1–12.
  5. Kouznetsov RL, Beals PF, 1996. Malaria: A Manual for Community Health Workers. Geneva: World Health Organization, 31.
  6. Zithromax. United States Package Insert. Pfizer, Inc. January Malaria: A Manual for Community Health Workers. Geneva: World Health Organization 2004.
  7. Gustafsson LL, Walker O, Alván G, Beermann B, Estevez F, Gleisner L, Lindstrom B, Sjoqvist F, 1983. Disposition of chloroquine in man after single intravenous and oral doses. Br J Clin Pharmacol 15 : 471–479.
  8. Frisk-Holmberg M, Bergqvist Y, Termond E, Domeij-Nyberg B, 1984. The single dose kinetics of chloroquine and its major metabolite desethylchloroquine in healthy subjects. Eur J Clin Pharmacol 26 : 521–530.
  9. Ofori-Adjei D, Ericsson O, Lindstrom B, Sjoqvist F, 1986. Protein binding of chloroquine enantiomers and desethylchloroquine. Br J Clin Pharmacol 22 : 356–358.
  10. Augustijns P, Geusens P, Verbeke N, 1992. Chloroquine levels in blood during chronic treatment of patients with rheumatoid arthritis. Eur J Clin Pharmacol 42 : 429–433.
  11. Biswas S, 2001. In-vitro antimalarial activity of azithromycin against chloroquine sensitive and chloroquine resistant Plasmodium falciparum. J Postgrad Med 47 : 240–243.
  12. Anderson SL, Berman J, Kuschner R, Wesche D, Magill A, Wellde B, Schneider I, Dunne M, Schuster BG, 1995. Prophylaxis of Plasmodium falciparum malaria with azithromycin administered to volunteers. Ann Intern Med. 123 : 771–773.
  13. Gray RH, Wabwire-Mangen F, Kigozi G, Sewankambo NK, Serwadda D, Moulton LH, Quinn TC, O’Brien KL, Meehan M, Abramowsky C, Robb M, Wawer MJ, 2001. Randomized trial of presumptive sexually transmitted disease therapy during pregnancy in Rakai, Uganda. Am J Obstet Gynecol 185 : 1209–1217.
http://instance.metastore.ingenta.com/content/journals/10.4269/ajtmh.2006.74.407
Loading
LACK OF A PHARMACOKINETIC INTERACTION BETWEEN AZITHROMYCIN AND CHLOROQUINE
The American Journal of Tropical Medicine and Hygiene 74, 407 (2006); https://doi.org/10.4269/ajtmh.2006.74.407
/content/journals/10.4269/ajtmh.2006.74.407
/content/journals/10.4269/ajtmh.2006.74.407
Loading

Data & Media loading...

  • Received : 08 Jun 2005
  • Accepted : 06 Nov 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error