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Volume 74, Issue 2
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645
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Abstract

A single 40 mg/kg dose of praziquantel (PZQ) continues to be the standard treatment for schistosomiasis caused by and in all clinical settings. Experimental development of drug resistance and the recent isolation of strains with a natural tolerance to high doses of PZQ have raised concerns over the adequacy of such a dose. We describe two Spanish travelers with genitourinary schistosomiasis caused by in whom repeated standard treatment failed to clear the infection.

Copyright 2006 The American Society of Tropical Medicine
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/content/journals/10.4269/ajtmh.2006.74.342
2006-02-01
2018-10-20

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References

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  2. Saathoff E, Olsen A, Magnussen P, Kvalsvig JD, Becker W, Appleton CC, 2004. Patterns of Schistosoma haematobium infection, impact of praziquantel treatment and re-infection after treatment in a cohort of schoolchildren from rural KwaZulu-Natal/South Africa. BMC Infect Dis 4 : 40.
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  4. Whitty CJM, Mabey DC, Armstrong M, Wright SG, Chiodini PL, 2000. Presentation and outcome of 1107 cases of schistosomiasis from Africa diagnosed in a non-endemic country. Trans R Soc Trop Med Hyg 94 : 531–534.
  5. Ismail M, Metwally A, Farghaly A, Bruce J, Tao LF, Bennett JL, 1996. Characterization of isolates of Schistosoma mansoni from Egyptian villagers that tolerate high doses of praziquantel. Am J Trop Med Hyg 55 : 214–218.
  6. Van Lieshout L, Stelma FF, Guisse F, Falcao ST, Ferreira ST, Polman K, van Dam GJ, Diakhate M, Sow S, Deelder A, Gryseels B, 1999. The contribution of host-related factors to low cure rates of praziquantel for the treatment of Schistosoma mansoni in Senegal. Am J Trop Med Hyg 61 : 760–765.
  7. Picquet M, Vercruysse J, Shaw DJ, Diop M, Ly A, 1998. Efficacy of praziquantel against Schistosoma mansoni in northern Senegal. Trans R Soc Trop Med Hyg 92 : 90–93.
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  11. Ismail M, Metwally A, Farghaly A, Bruce J, Tao LF, Bennett JL, 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 : 932–935.
  12. King CH, Muchiri EM, Ouma JH, 2000. Evidence against rapid emergence of praziquantel resistance in Schistosoma haematobium, Kenya. Emerg Infect Dis 6 : 585–594.
  13. Kumar V, Gryseels B, 1994. Use of Praziquantel against schistosomiasis: a review of the current status. Int J Antimicrob Agents 4 : 313–320.
  14. Mourao SC, Costa PI, Salgado HR, Gremiao MP, 2005. Improvement of antischistosomal activity of praziquantel by incorporation into phosphatidylcholine-containing liposomes. Int J Pharm 295 : 157–162.
  15. Ismail M, Botros S, Metwally A, William S, Farghally A, Tao LF, Day TA, Bennett JL, 1999. Resistance to praziquantel: direct evidence from Schistosoma mansoni isolated from Egyptian villagers. Am J Trop Med Hyg 60 : 932–935.
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Supplementary Data

Erratum

  • In Am J Trop Med Hyg 74: 342�344 by Alonso et al, there is an error in the fifth paragraph of the discussion on page 343. The sentence reads �However, three years later a treatment failure with PZQ at a standard dose in a returning traveler with S. haematobium infection was reported in whom a course of 40 mg/kg for three consecutive days was finally curative.� The sentence should have refered to a case of S. mansoni, not S. haematobium.

  • Received : 05 Aug 2005
  • Accepted : 26 Aug 2005

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