1921
Volume 74, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Meiotic recombination generates allelic diversity in the merozoite surface protein 1 () gene. In this study, we monitored recombination-based diversity of in Guadalcanal, the Solomon Islands, where malaria transmission is high. We identified 5′ recombinant types, 3′ sequence types, and haplotypes (unique associations of 5′ recombinant types and 3′ sequence types), and compared them with those from areas of low transmission in Thailand and Vanuatu. The mean number of 5′ recombinant types per person (multiplicity) was lower in Guadalcanal than in Thailand. Guadalcanal populations had 6–8 haplotypes; the numbers are comparable to Vanuatu but much lower than in Thailand. There were marked geographic differences in distribution of haplo-types. Linkage disequilibrium in was stronger in Guadalcanal than in Thailand, suggesting limited recombination events in the Solomon Islands. We suggest that the frequency of recombination events in is determined not only by transmission intensity but by the number of alleles prevalent and multiplicity of infections.

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2006-01-01
2017-09-23
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  • Received : 14 Mar 2005
  • Accepted : 31 Aug 2005

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