Volume 74, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Haptoglobin (Hp) levels were investigated in relation to host genotype in a malaria-endemic area in Gabon. A cross-sectional study of 1–12-year-old children was conducted in the rainy season, a period of high malaria transmission, to examine this relationship. Variables that influenced Hp levels were Hp genotype, location, and age interacting with parasite density. At low parasite densities, there was a negative correlation between Hp levels and age. At higher densities, there was a positive correlation with age. This suggests that in the presence of greater parasite-induced hemolysis, older children are capable of increased production of Hp. Sickle cell trait and ABO blood group was not associated with Hp levels in this population.


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  1. Lim SK, Ferraro B, Moore K, Halliwell B, 2001. Role of haptoglobin in free hemoglobin metabolism. Redox Rep 6 : 219–227.
  2. Langlois MR, Delanghe JR, 1996. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 42 : 1589–1600.
  3. Okazaki T, Nagai T, 1997. Difference in hemoglobin–binding ability of polymers among haptoglobin phenotypes. Clin Chem 43 : 2012–2013.
  4. Dobryszycka W, 1987. Przydatnosc oznaczen haptoglobiny w diagnostyce laboratoryjnej. Diagnostika Laboratoryjna 23 : 117–135.
  5. Imrie H, Ferguson D, Day KP, 2004. Human serum haptoglobin is toxic to Plasmodium falciparum in vitro. Mol Biochem Parasitol 133 : 93–98.
  6. Hunt NH, Driussi C, Sai–Kiang L, 2001. Haptoglobin and malaria. Redox Rep 6 : 389–392.
  7. Eaton JW, Brandt P, Mahoney JR, Lee JT Jr, 1982. Haptoglobin: a natural bacteriostat. Science 215 : 691–693.
  8. Delanghe J, Langlois M, Ouyang J, Claeys G, De Buyzere M, Wuyts B, 1998. Effect of haptoglobin phenotypes on growth of Streptococcus pyogenes. Clin Chem Lab Med 36 : 691–696.
  9. Trape JF, Fribourg–Blanc A, Bosseno MF, Lallemant M, Engler R, Mouchet J, 1985. Malaria, cause of ahaptoglobinaemia in Africans. Trans R Soc Trop Med Hyg 79 : 430–434.
  10. McGuire W, D’Alessandro U, Olaleye BO, Thomson MC, Langerock P, Greenwood BM, Kwiatkowski D, 1996. C-reactive protein and haptoglobin in the evaluation of a community-based malaria control programme. Trans R Soc Trop Med Hyg 90 : 10–14.
  11. Ashley-Koch A, Yang Q, Olney RS, 2000. Sickle hemoglobin (HbS) allele and sickle cell disease: a HuGE review. Am J Epidemiol 151 : 839–845.
  12. Greenwood BM, Marsh K, Snow RW, 1991. Why do some African children develop severe malaria? Parasitol Today 7 : 277–281.
  13. Steinberg M, 2001. Sickle cell trait. Steinburg M, Forget B, Higgs D, Nagel RL, eds. Disorders of Hemoglobin: Genetics, Pathophysiology and Clinical Management. Cambridge, United Kingdom: Cambridge University Press, 811–830.
  14. Boreham PF, Lenahan JK, Port GR, McGregor IA, 1981. Haptoglobin polymorphism and its relationship to malaria infections in The Gambia. Trans R Soc Trop Med Hyg 75 : 193–200.
  15. Elissa N, Migot–Nabias F, Luty A, Renaut A, Toure F, Vaillant M, Lawoko M, Yangari P, Mayombo J, Lekoulou F, Tshipamba P, Moukagni R, Millet P, Deloron P, 2003. Relationship between entomological inoculation rate, Plasmodium falciparum prevalence rate, and incidence of malaria attack in rural Gabon. Acta Trop 85 : 355–361.
  16. Ntoumi F, Ekala MT, Makuwa M, Lekoulou F, Mercereau–Puijalon O, Deloron P, 2002. Sickle cell trait carriage: imbalanced distribution of IgG subclass antibodies reactive to Plasmodium falciparum family-specific MSP2 peptides in serum samples from Gabonese children. Immunol Lett 84 : 9–16.
  17. Cox MJ, Kum DE, Tavul L, Narara A, Raiko A, Baisor M, Alpers MP, Medley GF, Day KP, 1994. Dynamics of malaria parasitaemia associated with febrile illness in children from a rural area of Madang, Papua New Guinea. Trans R Soc Trop Med Hyg 88 : 191–197.
  18. Migot–Nabias F, Mombo LE, Luty AJ, Dubois B, Nabias R, Bisseye C, Millet P, Lu CY, Deloron P, 2000. Human genetic factors related to susceptibility to mild malaria in Gabon. Genes Immun 1 : 435–441.
  19. Yano A, Yamamoto Y, Miyaishi S, Ishizu H, 1998. Haptoglobin genotyping by allele-specific polymerase chain reaction amplification. Acta Med Okayama 52 : 173–181.
  20. Venables W, Ripley B, 2002. Modern Applied Statistics with S. New York: Springer–Verlag.
  21. Trape JF, Fribourg–Blanc A, 1988. Ahaptoglobinemia in African populations and its relation to malaria endemicity. Am J Epidemiol 127 : 1282–1288.
  22. Kasvosve I, Gomo Zvenyika AR, Gangaidzo Innocent T, Mvundura E, Saungweme T, Moyo Victor M, Khumalo H, Boelaert Johan R, Gordeuk Victor R, Delanghe Joris R, 2000. Reference range of serum haptoglobin is haptoglobin phenotype-dependent in blacks. Clin Chim Acta 296 : 163–170.
  23. Jakobsen PH, McKay V, N’Jie R, Olaleye BO, D’Alessandro U, Zhang GH, Eggelte TA, Koch C, Greenwood BM, 1998. Decreased antitoxic activities among children with clinical episodes of malaria. Infect Immun 66 : 1654–1659.
  24. Sisay F, Byass P, Snow RW, Greenwood BM, Perrin LH, Yerly S, 1992. Measurement of serum haptoglobin as an indicator of the efficacy of malaria intervention trials. Trans R Soc Trop Med Hyg 86 : 14–16.
  25. Allison A, Blumberg B, Rees A, 1958. Haptoglobin types in British, Spanish Basque and Nigerian African populaitons. Nature 181 : 824–825.
  26. Barnicot NA, Garlick JP, Roberts DF, 1960. Haptoglobin and transferrin inheritance in northern Nigerians. Ann Hum Genet 24 : 171–183.
  27. Blumberg B, Gentile Z, 1961. Haptoglobins and transferrins of two tropical populations. Nature 189 : 897–899.
  28. Lefèvre-Witier P, 1974. Structure génétique des systèmes sanguins érythrocytaires et sériques chez les Kel Kummer. Population 29 : 517–527.
  29. Rougemont A, Quilici M, Delmont J, Ardissone JP, 1980. Is the HpO phenomenon in tropical populations really genetic? Hum Hered 30 : 201–203.
  30. Neel JV, Robinson AR, Zuelzer WW, Livingstone FB, Sutton HE, 1961. The frequency of elevations in the A and fetal hemoglobin fractions in the natives of Liberia and adjacent regions, with data on haptoglobin and transferrin types. Am J Hum Genet 13 : 262–278.
  31. Giblett ER, Motusky AG, Fraser GR, 1966. Population genetic studies in the Congo. IV. Haptoglobin and transferrin serum groups in the Congo and in other African populations. Am J Hum Genet 18 : 553–558.
  32. Moullec J, Kane Y, Ruffie J, Nguyenvan C, 1964. Haptogobin and transferring groups in 4 samples of the Senegal population. Transfusion (Paris) 61 : 161–164.
  33. Vu Tien J, Pison G, Levy D, Darcos JC, Constans J, Bernard J, 1975. Quantitative study of the genetics of haptoglobin levels. C R Acad Sci Hebd Seances Acad Sci D 280 : 2417–2419.
  34. Allison AC, Barnicot NA, 1960. Haptoglobins and transferrins in some East African peoples. Acta Genet Stat Med 10 : 17–23.
  35. Aubouy A, Migot–Nabias F, Deloron P, 2003. Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon. Malar J 2 : 12.
  36. Hurt N, Smith T, Tanner M, Mwankusye S, Bordmann G, Weiss NA, Teuscher T, 1994. Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa. Trans R Soc Trop Med Hyg 88 : 182–186.
  37. Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY, 1999. Reference distributions for the negative acute–phase serum proteins, albumin, transferrin and transthyretin: a practical, simple and clinically relevant approach in a large cohort. J Clin Lab Anal 13 : 273–279.
  38. Ritchie RF, Palomaki GE, Neveux LM, Navolotskaia O, Ledue TB, Craig WY, 2000. Reference distributions for the positive acute phase serum proteins, alpha1-acid glycoprotein (oroso-mucoid), alpha1-antitrypsin, and haptoglobin: a practical, simple, and clinically relevant approach in a large cohort. J Clin Lab Anal 14 : 284–292.
  39. Hurt N, Smith T, Teuscher T, Tanner M, 1994. Do high levels of C-reactive protein in Tanzanian children indicate malaria morbidity. Clin Diagn Lab Immunol 1 : 437–444.
  40. Raynes JG, Eagling S, McAdam KP, 1991. Acute-phase protein synthesis in human hepatoma cells: differential regulation of serum amyloid A (SAA) and haptoglobin by interleukin-1 and interleukin-6. Clin Exp Immunol 83 : 488–491.
  41. Al-Shakour AA, Al-Suhail AA, 2000. Percentage of HbS among cases of sickle-cell trait in Basra, Iraq. East Mediterr Health J 6 : 233–237.

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  • Received : 18 Jan 2005
  • Accepted : 29 Aug 2005

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