1921
Volume 74, Issue 1
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

Dengue virus infection can cause mild dengue fever (DF) or severe dengue hemorrhagic fever (DHF) and dengue shock syndrome (DSS). Cytokines are believed to be involved in the pathogenesis of dengue infection. However, the role of the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) in dengue infection is unclear. In this study, serum levels of MIF in adult dengue patients with different disease severity and clinical outcome were determined and compared with the levels of other cytokines, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-10, and interferon gamma (IFN-γ), in the same patients. Serum levels of MIF, IL-6, and IL-10, but not IFN-γ or TNF-α, were higher in all DHF patients who died than in DHF survivors and DF patients. We conclude that in addition to IL-6 and IL-10, elevated levels of serum MIF are a potential predictor of disease severity and clinical outcome in dengue patients.

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2006-01-01
2017-11-18
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References

  1. Baugh JA, Bucala R, 2002. Macrophage migration inhibitory factor. Crit Care Med 30 : S27–S35.
  2. Calandra T, Roger T, 2003. Macrophage migration inhibitory factor: a regulator of innate immunity. Nat Rev Immunol 3 : 791–800.
  3. Donnelly SC, Bucala R, 1997. Macrophage migration inhibitory factor: a regulator of glucocorticoid activity with a critical role in inflammatory disease. Mol Med Today 3 : 502–507.
  4. Chuang CC, Hung CJ, Tsai MC, Yeh TM, Chuang YC, 2004. High concentrations of circulating macrophage migration inhibitory factor in patients with severe blunt trauma: Is serum macrophage migration inhibitory factor concentration a valuable prognostic factor? Crit Care Med 32 : 734–739.
  5. Lehmann LE, Novender U, Schroeder S, Pietsch T, von Spiegel T, Putensen C, Hoeft A, Stuber F, 2001. Plasma levels of macrophage migration inhibitory factor are elevated in patients with severe sepsis. Intensive Care Med 27 : 1412–1415.
  6. Gando S, Nishihira J, Kobayashi S, Morimoto Y, Nanzaki S, Kemmotsu O, 2001. Macrophage migration inhibitory factor is a critical mediator of systemic inflammatory response syndrome. Intensive Care Med 27 : 1187–1193.
  7. Martin TR, 2000. MIF mediation of sepsis. Nat Med 6 : 140–141.
  8. Bozza FA, Gomes RN, Japiassu AM, Soares M, Castro-Faria-Neto HC, Bozza PT, Bozza MT, 2004. Macrophage migration inhibitory factor levels correlate with fatal outcome in sepsis. Shock 22 : 309–313.
  9. Calandra T, Echtenacher B, Roy DL, Pugin J, Metz CN, Hultner L, Heumann D, Mannel D, Bucala R, Glauser MP, 2000. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat Med 6 : 164–170.
  10. Henchal EA, Putnak JR, 1990. The dengue viruses. Clin Microbiol Rev 3 : 376–396.
  11. Pinheiro FP, Corber SJ, 1997. Global situation of dengue and dengue haemorrhagic fever, and its emergence in the Americas. World Health Stat Q 50 : 161–169.
  12. World Health Organization, 1997. Dengue Hemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. Second edition. Geneva: World Health Organization.
  13. Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11 : 480–496.
  14. Yadav M, Kamath KR, Iyngkaran N, Sinniah M, 1991. Dengue haemorrhagic fever and dengue shock syndrome: are they tumour necrosis factor-mediated disorders? FEMS Microbiol Immunol 4 : 45–49.
  15. Vitarana T, de Silva H, Withana N, Gunasekera C, 1991. Elevated tumour necrosis factor in dengue fever and dengue haemorrhagic fever. Ceylon Med J 36 : 63–65.
  16. Hober D, Poli L, Roblin B, Gestas P, Chungue E, Granic G, Imbert P, Pecarere JL, Vergez-Pascal R, Wattre P, 1993. Serum levels of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) in dengue-infected patients. Am J Trop Med Hyg 48 : 324–331.
  17. Nguyen TH, Lei HY, Nguyen TL, Lin YS, Huang KJ, Le BL, Lin CF, Yeh TM, Do QH, Vu TQ, Chen LC, Huang JH, Lam TM, Liu CC, Halstead SB, 2004. Dengue hemorrhagic fever in infants: a study of clinical and cytokine profiles. J Infect Dis 189 : 221–232.
  18. Avila-Aguero ML, Avila-Aguero CR, Um SL, Soriano-Fallas A, Canas-Coto A, Yan SB, 2004. Systemic host inflammatory and coagulation response in the dengue virus primo-infection. Cytokine 27 : 173–179.
  19. Perez AB, Garcia G, Sierra B, Alvarez M, Vazquez S, Cabrera MV, Rodriguez R, Rosario D, Martinez E, Denny T, Guzman MG, 2004. IL-10 levels in dengue patients: some findings from the exceptional epidemiological conditions in Cuba. J Med Virol 73 : 230–234.
  20. Juffrie M, Meer GM, Hack CE, Haasnoot K, Sutaryo, Veerman AJ, Thijs LG, 2001. Inflammatory mediators in dengue virus infection in children: interleukin-6 and its relation to C-reactive protein and secretory phospholipase A2. Am J Trop Med Hyg 65 : 70–75.
  21. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Rothman AL, Ennis FA, 1999. Elevated plasma interleukin-10 levels in acute dengue correlate with disease severity. J Med Virol 59 : 329–334.
  22. Lee IK, Liu JW, Yang KD, 2005. Clinical characteristics and risk factors for concurrent bacteremia in adults with dengue hemorrhagic fever. Am J Trop Med Hyg 72 : 221–226.
  23. Doxey DL, Nares S, Park B, Trieu C, Cutler CW, Iacopino AM, 1998. Diabetes-induced impairment of macrophage cytokine release in a rat model: potential role of serum lipids. Life Sci 63 : 1127–1136.
  24. Halstead SB, O’Rourke EJ, 1977. Antibody-enhanced dengue virus infection in primate leukocytes. Nature 265 : 739–741.
  25. Halstead SB, O’Rourke EJ, 1977. Dengue viruses and mono-nuclear phagocytes. I. Infection enhancement by non-neutralizing antibody. J Exp Med 146 : 201–217.
  26. Green S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Suntayakorn S, Nisalak A, Lew R, Innis BL, Kurane I, Rothman AL, Ennis FA, 1999. Early immune activation in acute dengue illness is related to development of plasma leakage and disease severity. J Infect Dis 179 : 755–762.
  27. Green S, Pichyangkul S, Vaughn DW, Kalayanarooj S, Nimmannitya S, Nisalak A, Kurane I, Rothman AL, Ennis FA, 1999. Early CD69 expression on peripheral blood lymphocytes from children with dengue hemorrhagic fever. J Infect Dis 180 : 1429–1435.
  28. Suharti C, van Gorp EC, Setiati TE, Dolmans WM, Djokomoeljanto RJ, Hack CE, ten CH, van der Meer JW, 2002. The role of cytokines in activation of coagulation and fibrinolysis in dengue shock syndrome. Thromb Haemost 87 : 42–46.
  29. van Gorp EC, Suharti C, ten Cate H, Dolmans WM, van der Meer JW, ten Cate JW, Brandjes DP, 1999. Review: infectious diseases and coagulation disorders. J Infect Dis 180 : 176–186.
  30. Shimizu T, Nishihira J, Watanabe H, Abe R, Honda A, Ishibashi T, Shimizu H, 2004. Macrophage migration inhibitory factor is induced by thrombin and factor Xa in endothelial cells. J Biol Chem 279 : 13729–13737.
  31. Bacher M, Eickmann M, Schrader J, Gemsa D, Heiske A, 2002. Human cytomegalovirus-mediated induction of MIF in fibroblasts. Virology 299 : 32–37.
  32. Liang CC, Sun MJ, Lei HY, Chen SH, Yu CK, Liu CC, Wang JR, Yeh TM, 2004. Human endothelial cell activation and apoptosis induced by enterovirus 71 infection. J Med Virol 74 : 597–603.
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  • Received : 17 Apr 2005
  • Accepted : 30 Aug 2005

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