Volume 74, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


The effect of erythropoietin treatment on infection in mice was studied. Survival rates of mice were dramatically improved by treatment with recombinant human erythropoietin (r-hu-EPO; 5000 U/kg) when infected with 1,000 cells of IL3000 ( < 0.05). All the untreated mice infected with IL3000 died by day 9 of infection; however, 100%, 50%, and 25% of the mice treated with r-hu-EPO for 8 days survived to day 20, day 40, and day 60 of the parasitical infection, respectively. Anti-8-hydroxy-2′-deoxyguanosine antibody, a biomarker for oxidative damage of DNA, yielded positive reactions in the cytoplasm of the parasites recovered from the mice treated with r-hu-EPO. These results, taken together, indicate that erythropoietin administration is effective for the treatment of infection.


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  1. Dargie JD, Murray PK, Murray M, Grimshaw WRT, Mc Intyre WIM, 1979. Bovine trypanosomiasis: the red cell kinetics of N’Dama and Zebu cattle infected with Trypanosoma congolense. Parasitology 78 : 271–286. [Google Scholar]
  2. Suliman HB, Logan-Henfrey L, Majiwa PAO, ole-Moiyoi O, Feldman BF, 1999. Analysis of erythropoietin and erythropoietin receptor genes expression in cattle during acute infection with Trypanosoma congolense. Exp Hematol 27 : 37–45. [Google Scholar]
  3. Witola WH, Lovelace CEA, 2001. Demonstration of erythroph-agocytosis in Trypanosoma congolense-infected goats. Vet Parasitol 96 : 115–126. [Google Scholar]
  4. Murray M, Dexter TM, 1998. Anaenia in bovine African trypanosomiasis. A review. Acta Tropica 45 : 389–432. [Google Scholar]
  5. Bear AN, Dessypris EN, Goldwasser E, Krantz SB, 1987. Blunted erythropoietin response to anaemia in rheumatoid arthritis. Bri J Haematol 66 : 559–564. [Google Scholar]
  6. Oster W, Herrman F, Gamm H, 1990. Erythropoietin for the treatment of anaemia of malignancy associated with neoplastic bone marrow infiltration. J Clin Oncol 8 : 956–962. [Google Scholar]
  7. Pincus T, Olsen NJ, Russel J, 1990. Multicenter study of recombinant human erythropoietin in correction of anaemia of rheumatoid arthritis. Am J Med 89 : 161–168. [Google Scholar]
  8. Buza JJ, Logan-Henfrey L, Andrianarivo AG, Williams DJL, 1995. Rise in erythropoietin concentrations in experimental Trymanosoma congolense infection of calves. J Comp Path 113 : 343–356. [Google Scholar]
  9. Rencricca NJ, Stout JP, Coleman RM, 1974. Erythropoietin production in virulent malaria. Infect Immun 10 : 831–833. [Google Scholar]
  10. Toyokuni S, Tanaka T, Hattori Y, Nishiyama Y, Yoshida A, Uchida K, Hiai H, Ochi H, Osawa T, 1997. Quantitative immunohistochemical determination of 8-hydroxy-2′-deoxyguanosine by a monoclonal antibody N45.1: its application to ferric nitrilotriacetate-induced renal carcinogenesis model. Lab Invest 76 : 365–374. [Google Scholar]
  11. Uchide T, Masuda H, Mitsui Y, Saida K, 1999. Gene expression of vasoactive intestinal contractor/endothelin-2 in ovary, uterus and embryo: comprehensive gene expression profiles of the endothelin ligand-receptor system revealed by semi-quantitative reverse transcription-polymerase chain reaction analysis in adult mouse tissues and during late embryonic development. J Mol Endocrinol 22 : 161–171. [Google Scholar]
  12. Whlhelm J, Pingoud A, Hahn M, 2003. Validation of an algorithm for automatic quantification of nucleic acid copy numbers by real-time polymerase chain reaction. Anal Biochem 317 : 218–225. [Google Scholar]
  13. Tabel H, Kaushik RS, Uzonna J, 1999. Experimental African trypanosomiasis: differences in cytokine and nitric oxide production by macrophages from resistant and susceptible mice. Pathobiology 67 : 273–276. [Google Scholar]
  14. Means RT, Krantz SB, 1992. Progress in understanding the anaemia of chronic disease. Blood 80 : 1639–1647. [Google Scholar]

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  • Received : 14 Oct 2005
  • Accepted : 14 Feb 2006

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