Volume 74, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by , emerges after chemotherapy.


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  • Received : 09 Dec 2005
  • Accepted : 28 Feb 2006

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