Volume 74, Issue 6
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


Mice deficient in phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS), which are primary macrophage killing mechanisms, generated tissue granulomas but showed unrestrained visceral replication and suboptimal initial responsiveness to antimony treatment. Nevertheless, visceral infection was controlled post-treatment and did not recur. A phox/iNOS-independent macrophage mechanism, which was not triggered by , emerges after chemotherapy.


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  1. Murray HW, Nathan CF, 1999. Macrophage microbicidal mechanisms in vivo: reactive nitrogen vs. intermediates in the killing of intracellular visceral Leishmania donovani. J Exp Med 189 : 741–746. [Google Scholar]
  2. Murray HW, Cartelli D, 1983. Killing of Leishmania donovani by human mononuclear phagocytes: oxygen-dependent and -independent leishmanicidal activity. J Clin Invest 72 : 32–44. [Google Scholar]
  3. Blos M, Schleicher U, Rochs FJS, Meibner U, Rollinghoff M, Bogdan C, 2003. Organ-specific and stage-dependent control of Leishmania major infection by inducible nitric oxide synthase and phagocyte NADPH oxidase. Eur J Immunol 33 : 1224–1234. [Google Scholar]
  4. Shiloh MU, MacMicking JD, Nicholson S, Brause JE, Potter S, Marino M, Fang F, Dinauer M, Nathan C, 1999. Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase. Immunity 10 : 29–38. [Google Scholar]
  5. Murray HW, Delph-Etienne S, 2000. Role of endogenous gamma interferon and macrophage microbicidal mechanisms in host responses to chemotherapy in experimental visceral leishmaniasis. Infect Immun 68 : 288–293. [Google Scholar]
  6. Murray HW, 2005. Prevention of relapse after chemotherapy in a chronic intracellular infection: mechanisms in experimental visceral leishmaniasis. J Immunol 174 : 4916–4923. [Google Scholar]
  7. Taylor GA, Feng CG, Sher A, 2004. P47 GTPases: regulators of immunity to intracellular pathogens. Nature Rev Immunol 4 : 100–109. [Google Scholar]
  8. Santiago HC, Feng CG, Bafica A, Roffe E, Aramtes RM, Cheever A, Taylor G, Vierira LQ, Aliberti J, Gazzinelli RT, Sher A, 2005. Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hematopoiesis and intracellular control of parasite growth. J Immunol 175 : 8165–8172. [Google Scholar]
  9. Shi X, Shanjin C, Mitsuhashi M, Xiang Z, Ma X, 2004. Genome-wide analysis of molecular changes in IL-12-induced control of mammary carcinoma via IFN-γ-independent mechanisms. J Immunol 172 : 4111–4117. [Google Scholar]
  10. White JK, Mastroeni P, Popoff J-F, Evans CAW, Blackwell JM, 2005. Slc11a1-mediated reistance to Salmonella enterica serovar Typhimurium and Leishmania donovani infections do not require functional inducible nitric oxide synthase or phagocyte oxidase activity. J Leukoc Biol 77 : 311–320. [Google Scholar]
  11. Roberts WL, Berman JD, Rainey PM, 1995. In vitro antileishmanial properties of tri- and pentavalent antimonial preparations. Antimicrob Agents Chemother 39 : 1234–1239. [Google Scholar]
  12. Sudhandiran G, Shaha C, 2003. Antimonial-induced increase in intracellular Ca2+ through non-selective cation channels in the host and the parasite is responsible for apoptosis of intracellular Leishmania donovani amastigotes. J Biol Chem 278 : 25120–25132. [Google Scholar]

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  • Received : 09 Dec 2005
  • Accepted : 28 Feb 2006

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