Volume 73, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


All pregnant women who came for delivery at a district hospital in Mandla and a civil hospital in Maihar were screened for (placental parasitemia using a rapid test and microscopy and peripheral and umbilical cord parasitemia using microscopy alone). Two rapid diagnostic tests (RDTs), Paracheck Pf and ParaHIT, were used. At Mandla, the sensitivity and specificity of the Paracheck Pf for were 93% and 84%, respectively. The positive predictive values (PPVs) and negative predictive values (NPVs) were 50% and 99%, respectively. At Maihar, the sensitivity and specificity of the ParaHIT for were 87.5% and 97%, respectively. The PPVs and NPVs were 75.4% and 98.7%, respectively. Placental infection was significantly associated with low birth weight. The RDTs for the identification of were more sensitive in placental blood than the placental blood smear by microscopy. Thus, the RDTs should be useful for rapid assessment of malaria at delivery.


Article metrics loading...

The graphs shown below represent data from March 2017
Loading full text...

Full text loading...



  1. Brabin BJ, 1991. The risks and severity of malaria in pregnant women. Applied Field Research in Malaria. Geneva: World Health Organization, 1–34.
  2. Menendez C, Ordi J, Ismail MR, Ventura PJ, Aponte JJ, Kahigwa E, Font F, Alonso PL, 2000. The impact of placental malaria on gestational age and birth weight. J Infect Dis 181 : 1740–1745. [Google Scholar]
  3. Leke RFG, Djokam RR, Mou R, Leke RJ, Fogako J, Megnekou R, Metenou S, Sama G, Zhou Y, Cadigan T, Parra M, Taylor DW, 1999. Detection of Plasmodium falciparum antigen histidine rich protein 2 in blood of pregnant women: implications for diagnosing placental malaria. J Clin Microbiol 37 : 2992–2996. [Google Scholar]
  4. Mankhambo L, Kanjala M, Rudman S, Lema VM, Rogerson SJ, 2002. Evaluation of the OptiMal rapid antigen test and species specific PCR to detect placental Plasmodium falciparum infection at delivery. J Clin Microbiol 40 : 155–158. [Google Scholar]
  5. Singh N, Shukla MM, Sharma VP, 1999. Epidemiology of malaria in pregnancy. Bull World Health Organ 77 : 567–571. [Google Scholar]
  6. Sholapurkar SL, Gupta AN, Mahajan RC, 1988. Clinical course of malaria in pregnancy a prospective controlled study from India. Trans R Soc Trop Med Hyg 82 : 376–379. [Google Scholar]
  7. Singh N, Saxena A, Srivastava R, 2003. Placental Plasmodium vivax infection and congenital malaria in central India. Ann Trop Med Parasitol 97 : 875–878. [Google Scholar]
  8. Singer LM, Newman RD, Diarra A, Moran AC, Huber CS, Stennies G, Sirima SB, Konate A, Yameogo M, Sawadogo R, Bernwell JW, Parise ME, 2004. Evaluation of a malaria rapid diagnostic test for assessing the burden of malaria during pregnancy. Am J Trop Med Hyg 70 : 481–485. [Google Scholar]
  9. WHO, 1996. A rapid dipstick antigen capture assasy for the diagnosis of falciparum malaria. WHO informal consultation on recent advances in diagnostic techniques for malaria. Bull World Health Organ 74 : 47–54. [Google Scholar]
  10. WHO, 2000. New Perspectives: Malaria Diagnosis. Report of a Joint WHO/USAID Informal Consultation October 25–27, 1999. Geneva: World Health Organization. WHO/CDS/RBM/2000, 14 and WHO/MAL/2000, 1091.
  11. Singh N, Mishra SS, Singh MP, Sharma VP, 2000. Seasonality of Plasmodium vivax and P. falciparum in tribal villages in central India (1987–1995). Ann Trop Med Parasitol 94 : 101–112. [Google Scholar]
  12. Singh N, Tyagi AK, Sharma VP, 1995. Drug resistant Plasmodium falciparum in Mandla district, Madhya Pradesh. Indian J Malariol 32 : 174–177. [Google Scholar]
  13. Singh N, Saxena A, 2005. Usefulness of rapid on-site Plasmodium falciparum diagnosis (Paracheck® Pf) in forest migrants and among the indigenous population at the site of their occupational activities in central India. Am J Trop Med Hyg 72 : 26–29. [Google Scholar]
  14. Singh N, Saxena A, Sharma VP, 2002. Usefulness of an inexpensive, Paracheck Pf test in detecting asymptomatic infectious reservoir of Plasmodium falciparum during dry season in an inaccessible terrain in central India. J Infect 45 : 165–168. [Google Scholar]
  15. Guthmann JP, Ruiz A, Priotto G, Kiguli J, Bonte L, Legros D, 2002. Validity, reliability and ease of use in the field of five rapid tests for the diagnosis of Plasmodium falciparum malaria in Uganda. Trans R Soc Trop Med Hyg 96 : 254–257. [Google Scholar]
  16. Tjitra E, Suprianto S, Dyer M, Currie BJ, Anstey NM, 1999. Field evaluation of the ICT malaria Pf/Pv immunochromatographic test for detection of Plasmodium falciparum and Plasmodium vivax in patients with a presumptive clinical diagnosis of malaria in eastern Indonesia. J Clin Microbiol 37 : 2412–2417. [Google Scholar]
  17. Mockenhaupt FP, Ulmen U, Gaertner CV, Addo GB, Bienzle U, 2002. Diagnosis of placental malaria. J Clin Microbiol 40 : 306–308. [Google Scholar]

Data & Media loading...

  • Received : 26 Apr 2005
  • Accepted : 06 Jul 2005

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error