Volume 73, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645


We assessed the prophylactic efficacy of azithromycin (250 mg/day) against malaria in 276 adults in western Thailand in a randomized, double-blind, placebo-controlled trial. After antimalarial suppressive treatment, volunteers were randomized in a 2:1 ratio to either the azithromycin or placebo, respectively. Study medication was given for an average of 74 days. The azithromycin group (n = 179) had five endpoint parasitemias (1 and 4 ), and the placebo group (n = 97) had 28 endpoint parasitemias (21 , 5 , and 2 mixed infections). Adverse events and compliance and withdrawal rates were similar in both groups. The protective efficacy (PE) of azithromycin was 98% for (95% confidence interval [CI] = 88–100%). There were too few cases to reliably estimate the efficacy of azithromycin for (PE =71%, 95% C =−14–94%). We conclude that daily azithromycin was safe, well-tolerated, and had a high efficacy for the prevention of malaria.


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  • Received : 18 Apr 2005
  • Accepted : 02 Jun 2005

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