1921
Volume 73, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

in Suriname was studied for the presence of drug resistance and genetic variation in blood samples of 86 patients with symptomatic malaria. Drug resistance was predicted by determining point mutations in the chloroquine resistance marker of the chloroquine resistance transporter () gene (codon 76) and the pyrimethamine-sulfadoxine resistance markers in the dihydrofolate reductase () gene (codons 16, 51, 59, 108, and 164) and dihydropteroate synthase () gene (codons 436, 437, 540, 581, and 613). Genetic variability was determined by sequence analysis of the polymorphic segments of the merozoite surface protein 2 () and glutamate-rich protein () genes. Mutations in the , , and genes were found in all samples tested, suggesting that resistance to chloroquine and antifolate drugs is present at a high frequency. A low number of alleles was found for the and genes. This indicates limited genetic diversity and, based on geographic data, a genetically homogeneous population in Suriname.

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2005-11-01
2017-11-18
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  • Received : 25 Nov 2004
  • Accepted : 11 Jul 2005

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