1921
Volume 73, Issue 5
  • ISSN: 0002-9637
  • E-ISSN: 1476-1645

Abstract

in Suriname was studied for the presence of drug resistance and genetic variation in blood samples of 86 patients with symptomatic malaria. Drug resistance was predicted by determining point mutations in the chloroquine resistance marker of the chloroquine resistance transporter () gene (codon 76) and the pyrimethamine-sulfadoxine resistance markers in the dihydrofolate reductase () gene (codons 16, 51, 59, 108, and 164) and dihydropteroate synthase () gene (codons 436, 437, 540, 581, and 613). Genetic variability was determined by sequence analysis of the polymorphic segments of the merozoite surface protein 2 () and glutamate-rich protein () genes. Mutations in the , , and genes were found in all samples tested, suggesting that resistance to chloroquine and antifolate drugs is present at a high frequency. A low number of alleles was found for the and genes. This indicates limited genetic diversity and, based on geographic data, a genetically homogeneous population in Suriname.

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References

  1. Peterson DS, Milhous WK, Wellems TE, 1990. Molecular basis of differential resistance to cycloguanil and pyrimethamine in Plasmodium falciparum malaria. Proc Natl Acad Sci USA 87 : 3018–3022. [Google Scholar]
  2. Foote SJ, Galatis D, Cowman AF, 1992. Selection for high-level chloroquine resistance results in deamplification of the pfmdr1 gene and increased sensitivity to mefloquine in Plasmodium falciparum. EMBO J 11 : 3067–3075. [Google Scholar]
  3. Wu Y, Kirkman LA, Wellems TE, 1996. Transformation of Plasmodium falciparum malaria parasites by homologous integration of plasmids that confer resistance to pyrimethamine. Proc Natl Acad Sci USA 93 : 1130–1134. [Google Scholar]
  4. Triglia T, Cowman AF, 1999. The mechanism of resistance to sulfa drugs in Plasmodium falciparum. Drug Resist Update 2 : 15–19. [Google Scholar]
  5. Brooks DR, Wang P, Read M, Watkins WM, Sims PF, Hyde JE, 1994. Sequence variation of the hydroxymethyldihydropterin pyrophosphokinase: dihydropteroate synthase gene in lines of the human malaria parasite, Plasmodium falciparum, with differing resistance to sulfadoxine. Eur J Biochem 224 : 397–405. [Google Scholar]
  6. Shaio MF, Wang P, Lee CS, Sims PF, Hyde JE, 1998. Development and comparison of quantitative assays for the dihydropteroate synthetase codon 540 mutation associated with sulfadoxine resistance in Plasmodium falciparum. Parasitology 116 : 203–210. [Google Scholar]
  7. White NJ, 2004. Antimalarial drug resistance. J Clin Invest 113 : 1084–1092. [Google Scholar]
  8. Wongsrichanalai C, Pickard AL, Wernsdorfer WH, Meshnick SR, 2002. Epidemiology of drug-resistant malaria. Lancet Infect Dis 2 : 209–218. [Google Scholar]
  9. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE, 2000. Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 6 : 861–871. [Google Scholar]
  10. Wellems TE, Plowe CV, 2001. Chloroquine-resistant malaria. J Infect Dis 184 : 770–776. [Google Scholar]
  11. Sidhu AB, Verdier-Pinard D, Fidock DA, 2002. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298 : 210–213. [Google Scholar]
  12. Schneider AG, Premji Z, Felger I, Smith T, Abdulla S, Beck HP, Mshinda H, 2002. A point mutation in codon 76 of pfcrt of P. falciparum is positively selected for by Chloroquine treatment in Tanzania. Infect Genet Evol 1 : 183–189. [Google Scholar]
  13. Plowe CV, Djimde A, Bouare M, Doumbo O, Wellems TE, 1995. Pyrimethamine and proguanil resistance-conferring mutations in Plasmodium falciparum dihydrofolate reductase: polymerase chain reaction methods for surveillance in Africa. Am J Trop Med Hyg 52 : 565–568. [Google Scholar]
  14. Wang P, Lee CS, Bayoumi R, Djimde A, Doumbo O, Swedberg G, Dao LD, Mshinda H, Tanner M, Watkins WM, Sims PF, Hyde JE, 1997. Resistance to antifolates in Plasmodium falciparum monitored by sequence analysis of dihydropteroate synthetase and dihydrofolate reductase alleles in a large number of field samples of diverse origins. Mol Biochem Parasitol 89 : 161–177. [Google Scholar]
  15. Snounou G, Zhu X, Siripoon N, Jarra W, Thaithong S, Brown KN, Viriyakosol S, 1999. Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand. Trans R Soc Trop Med Hyg 93 : 369–374. [Google Scholar]
  16. Aubouy A, Migot-Nabias F, Deloron P, 2003. Polymorphism in two merozoite surface proteins of Plasmodium falciparum isolates from Gabon. Malar J 2 : 12. [Google Scholar]
  17. Ponnudurai T, Lensen AH, van Gemert GJ, Bensink MP, Bolmer M, Meuwissen JH, 1989. Infectivity of cultured Plasmodium falciparum gametocytes to mosquitoes. Parasitology 98 : 165–173. [Google Scholar]
  18. Vieira PP, Ferreira MU, Alecrim MG, Alecrim WD, da Silva LH, Sihuincha MM, Joy DA, Mu J, Su XZ, Zalis MG, 2004. pfcrt Polymorphism and the spread of chloroquine resistance in Plasmodium falciparum populations across the Amazon Basin. J Infect Dis 190 : 417–424. [Google Scholar]
  19. Cortese JF, Plowe CV, 1998. Antifolate resistance due to new and known Plasmodium falciparum dihydrofolate reductase mutations expressed in yeast. Mol Biochem Parasitol 94 : 205–214. [Google Scholar]
  20. Vasconcelos KF, Plowe CV, Fontes CJ, Kyle D, Wirth DF, Pereira da Silva LH, Zalis MG, 2000. Mutations in Plasmodium falciparum dihydrofolate reductase and dihydropteroate synthase of isolates from the Amazon region of Brazil. Mem Inst Oswaldo Cruz 95 : 721–728. [Google Scholar]
  21. Schmider N, Peyerl-Hoffmann G, Restrepo M, Jelinek T, 2003. Short communication: point mutations in the dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum isolates from Colombia. Trop Med Int Health 8 : 129–132. [Google Scholar]
  22. Urdaneta L, Plowe C, Goldman I, Lal AA, 1999. Point mutations in dihydrofolate reductase and dihydropteroate synthase genes of Plasmodium falciparum isolates from Venezuela. Am J Trop Med Hyg 61 : 457–462. [Google Scholar]
  23. Giraldo LE, Acosta MC, Labrada LA, Praba A, Montenegro- James S, Saravia NG, Krogstad DJ, 1998. Frequency of the Asn-108 and Thr-108 point mutations in the dihydrofolate reductase gene in Plasmodium falciparum from southwest Colombia. Am J Trop Med Hyg 59 : 124–128. [Google Scholar]
  24. Peterson DS, Di Santi SM, Povoa M, Calvosa VS, Do Rosario VE, Wellems TE, 1991. Prevalence of the dihydrofolate reductase Asn-108 mutation as the basis for pyrimethamine-resistant falciparum malaria in the Brazilian Amazon. Am J Trop Med Hyg 45 : 492–497. [Google Scholar]
  25. Oostburg BF, Jozefzoon LM, 1983. Fansidar resistant Plasmodium falciparum infection in Surinam. Trop Geogr Med 35 : 243–247. [Google Scholar]
  26. Oostburg BF, 1973. Chloroquine-resistant tropical malaria in south Surinam. Ned Tijdschr Geneeskd 117 : 693–694. [Google Scholar]
  27. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D, 2001. A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 344 : 257–263. [Google Scholar]
  28. Lefevre G, Looareesuwan S, Treeprasertsuk S, Krudsood S, Silachamroon U, Gathmann I, Mull R, Bakshi R, 2001. A clinical and pharmacokinetic trial of six doses of artemether-lumefantrine for multidrug-resistant Plasmodium falciparum malaria in Thailand. Am J Trop Med Hyg 64 : 247–256. [Google Scholar]
  29. Konate L, Zwetyenga J, Rogier C, Bischoff E, Fontenille D, Tall A, Spiegel A, Trape JF, Mercereau-Puijalon O, 1999. Variation of Plasmodium falciparum msp1 block 2 and msp2 allele prevalence and of infection complexity in two neighbouring Senegalese villages with different transmission conditions. Trans R Soc Trop Med Hyg 93 (Suppl 1): 21–28. [Google Scholar]
  30. Peyerl-Hoffmann G, Jelinek T, Kilian A, Kabagambe G, Metzger WG, von Sonnenburg F, 2001. Genetic diversity of Plasmodium falciparum and its relationship to parasite density in an area with different malaria endemicities in West Uganda. Trop Med Int Health 6 : 607–613. [Google Scholar]
  31. Beck HP, Felger I, Huber W, Steiger S, Smith T, Weiss N, Alonso PL, Tanner M, 1997. Analysis of multiple Plasmodium falciparum infections in Tanzanian children during the phase III trial of the malaria vaccine SPf66. J Infect Dis 175 : 921–926. [Google Scholar]
  32. Ekala MT, Jouin H, Lekoulou F, Mercereau-Puijalon O, Ntoumi F, 2002. Allelic family-specific humoral responses to merozoite surface protein 2 (MSP2) in Gabonese residents with Plasmodium falciparum infections. Clin Exp Immunol 129 : 326–331. [Google Scholar]
  33. Ariey F, Chalvet W, Hommel D, Peneau C, Hulin A, Mercereau-Puijalon O, Duchemin JB, Sarthou JL, Reynes JM, Fandeur T, 1999. Plasmodium falciparum parasites in French Guiana: limited genetic diversity and high selfing rate. Am J Trop Med Hyg 61 : 978–985. [Google Scholar]
  34. Haddad D, Snounou G, Mattei D, Enamorado IG, Figueroa J, Stahl S, Berzins K, 1999. Limited genetic diversity of Plasmodium falciparum in field isolates from Honduras. Am J Trop Med Hyg 60 : 30–34. [Google Scholar]
  35. Sallenave-Sales S, Ferreira-da-Cruz MF, Faria CP, Cerruti C Jr, Daniel-Ribeiro CT, Zalis MG, 2003. Plasmodium falciparum: limited genetic diversity of MSP-2 in isolates circulating in Brazilian endemic areas. Exp Parasitol 103 : 127–135. [Google Scholar]
  36. Montoya L, Maestre A, Carmona J, Lopes D, Do Rosario V, Blair S, 2003. Plasmodium falciparum: diversity studies of isolates from two Colombian regions with different endemicity. Exp Parasitol 104 : 14–19. [Google Scholar]
  37. Cortese JF, Caraballo A, Contreras CE, Plowe CV, 2002. Origin and dissemination of Plasmodium falciparum drug-resistance mutations in South America. J Infect Dis 186 : 999–1006. [Google Scholar]
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  • Received : 25 Nov 2004
  • Accepted : 11 Jul 2005

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